Trace determination of chlorpheniramine in human plasma using magnetic dispersive solid-phase extraction based on a graphene oxide/Fe₃O₄@polythionine nanocomposite combined with high-performance liquid chromatography

Abstract

Graphene oxide/Fe3O4@polythionine (GO/Fe3O4@PTh) nanocomposite was fabricated for magnetic dispersive solid-phase extraction and high-performance liquid chromatography-ultraviolent detection (HPLC) of chlorpheniramine in human plasma.

Green Bioanalytical Applications of Graphene Oxide for the Extraction of Small Organic Molecules

“…In order to extract trace amounts of chloropheniramine from human plasma, Daryakenary et al [ 69 ] prepared a mGO@polythione nanocomposite for the M-dSPE of the compound. Thionine was polymerized onto the mGO’s surface with an oxidative polymerization reaction.…”

Magnetic Solid-Phase Extraction of Organic Compounds Based on Graphene Oxide Nanocomposites

“…Polythionine was also employed for the functionalization of magnetic graphene oxide through an oxidative polymerization reaction of thionine on the surface of GO/Fe 3 O 4 [84,85]. This surface modification significantly improved the merits of GO/Fe 3 O 4 , providing satisfactory extraction efficiency.…”

“…This surface modification significantly improved the merits of GO/Fe 3 O 4 , providing satisfactory extraction efficiency. The functionalized nanocomposite was used for the MSPE of chlorpheniramine [84] and duloxetine [85] from human plasma prior to their determination by HPLC-UV.…”

Fabrication of ZIF-71/Fe3O4/polythionine nanoarray-functionalized carbon cotton cloth for simultaneous extraction and quantitation of febuxostat and diclofenac

“…[19][20][21][22][23] Extreme attempts have been conducted to introduce new magnetic sorbents and apply them in special analytical purposes. [24][25][26][27] However, the introduced extractors suffer from some disadvantages such as lack of reusability, low surface area-to-volume ratio, insufficient porosity, high cost of synthesis, unacceptable selectivity, etc. In this regard, carbonized cotton cloth (CC) as a novel class of carbon-based material, seems superior substance for fabricating an efficient and reusable hybrid material for extraction and enrichment of target compounds form complex matrices.…”

“…In order to improve the properties of carbon based material for isolation and enrichment purposes, conductive polymers such as polythionine, polyaniline, polythiophene, polytyramine seem appropriate choices which extensively enhance p-p interaction, hydrophobic possessions, extraction facility, diffusion rate and reusability. [24][25][26][27]35,36,46 In the presented study, CC was functionalized with ZIF-71 to result CC/ZIF-71 and followed with coprecipitation of Fe 3 O 4 to provide a super-magnetic material. In the next synthesis route, polymerization of thionine was performed on the surface of CC/ ZIF-71/Fe 3 O 4 to nalize the modication of CC with nano-arrays of substances.…”