Trace determination of uric acid based on double C-type five-frequency resonant metamaterial sensor

Abstract

A rapid trace detection method for uric acid (UA) content based on terahertz metamaterial sensor was developed. UA is the final oxide of purine metabolism in human body and one of serum inflammatory markers. The continuous increase of serum UA content can cause a series of diseases in human body, so the detection and analysis of UA has been widely used in clinical diagnosis and treatment of diseases in recent years. The traditional methods for detecting UA have the disadvantages of high cost of reagents and complicated chemical analysis. However, the detection method of terahertz metamaterial sensor solves this problem well, with fast detection speed, small reagent dosage, non-destructive without labels, and no damage to the analyte. In this work, a double-C-type multi-resonant metamaterial sensor based on aluminum and polyimide materials is designed. The sensor has five resonant peaks in the frequency range of 0.1-1.0 THz, and the highest sensitivity is 208 GHz/RIU, which can be applied to high sensitivity trace detection. The results show that the minimum detection limit of the sensor is 0.001 mg/mL, which is lower than the minimum content of UA in healthy human body. It is expected to be applied to the detection of biomedicine and other fields.