Trace element profile in pemphigus foliaceus and in pemphigus vulgaris patients from Southeastern Brazil

Serra, Leonardo La; Salathiel, Adriana Martinelli; Trevilato, Tânia Maria Beltramini; Alves, Renato I. S.; Souza, Vanessa Cristina de Oliveira; Barbosa, Fernando; Roselino, Ana Maria

doi:10.1016/j.jtemb.2018.09.005

Cited by 5 publications

(4 citation statements)

References 44 publications

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“…Pemphigus is endemic in Southeastern Brazil and Pb is known to play an immunomodulatory role that favors Th2 proliferation and consequent production of Th2 cytokines. Pb contamination in chronic doses may constitute a trigger factor for PV pathogenesis (139). Taken together, the relevance of nutritional factors seems to be underestimated in the induction of PV.…”

Section: Dietmentioning

confidence: 99%

The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors

et al. 2023

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Pemphigus vulgaris (PV) is a potentially life-threatening blistering disorder characterized by autoantibodies directed against cell-cell adhesion molecules that serves as an excellent model to study human autoimmune development. Numerous studies have identified specific Human Leukocyte Antigen (HLA) genes, in particular DRB1*0402 and DQB1*0503, that confer disease risk. Although HLA is required, it is not sufficient for the initiation of disease. As with all autoimmune diseases, the etio-pathogenesis of PV is complex, meaning it is multifactorial. Susceptibility is polygenic, and the search for non-HLA disease-linked genes continues. Moreover, twin studies across autoimmune conditions indicate that non-genetic environmental and lifestyle factors, which can be collectively grouped under the term “exposome”, are also major contributors to disease development. The literature presents evidence for the potential role of multiple triggers such as medications, infections, stress, diet, immunizations, and sleep to influence the etiology, pathophysiology, and prognosis of PV. However, a clear understanding of the degree to which specific factors impact PV is lacking. In this investigation, we comprehensively review the environmental elements listed above and consider the strength of evidence for these factors. The overall goals of this work are to provide greater insights into the factors that influence disease susceptibility, disease development and disease course and ultimately help to better guide clinicians and inform patients in the management of PV.

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Section: Dietmentioning

confidence: 99%

The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors

et al. 2023

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“…Exogenous factors have been associated with pemphigus pathogenesis, including drugs and nutritional elements rich in thiol, heavy metals, herpes virus infection, and insect bite. 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 Furthermore, in case-control studies based on interviews, exposure to pesticides, mainly organophosphates (OP), has been related to PV in Asia, Europe, and North America, 15 , 16 , 17 , 18 , 19 and also to “fogo selvagem” in Brazil. 20 PV following contact dermatitis with dihydrodiphenyltrichlororethane and diazinon has been described.…”

Section: Introductionmentioning

confidence: 99%

Measurement of pesticides in hair samples from pemphigus foliaceus and pemphigus vulgaris patients in Southeastern Brazil

Serra

Salathiel

Lanaro

et al. 2023

Anais Brasileiros de Dermatologia

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“… 1 , 2 Both pemphigus vulgaris (PV) and pemphigus foliaceus (PF) clinical forms are prevalent in some Brazilian regions, whose pathogenesis has yet been extensibility studied. 3 , 4 , 5 , 6 In Southeastern Brazil, HLA susceptibility/protective alleles/haplotypes have been identified, differentiating PV from PF in terms of HLA genetic profile. 7 …”

Section: Introductionmentioning

confidence: 99%

Dexamethasone-cyclophosphamide pulse therapy outcomes comparing pemphigus vulgaris and pemphigus foliaceus groups in a Brazilian cohort study

Fontenelle

Filho

Vernal

et al. 2023

Anais Brasileiros de Dermatologia

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Trace element profile in pemphigus foliaceus and in pemphigus vulgaris patients from Southeastern Brazil

Cited by 5 publications

References 44 publications

The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors

The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors

Measurement of pesticides in hair samples from pemphigus foliaceus and pemphigus vulgaris patients in Southeastern Brazil

Dexamethasone-cyclophosphamide pulse therapy outcomes comparing pemphigus vulgaris and pemphigus foliaceus groups in a Brazilian cohort study

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