Trace element status in patients with type 2 diabetes in Norway: The HUNT3 Survey

Abstract

Several epidemiological studies have indicated that a number of trace elements may play a role in type 2 diabetes (T2D). We investigated the association between prevalent T2D and the concentrations of 25 trace elements in whole blood, and the relationships between T2D duration and blood levels of the trace elements that we found to be related to T2D prevalence. In this population based case-control study, 267 patients with self-reported T2D and 609 controls (frequency matched), were selected from the third Nord-Trøndelag Health Survey. Trace element blood levels were determined by high resolution inductively coupled plasma-mass spectrometry. Multivariable conditional logistic regression and multivariable linear regression were used to estimate associations. The prevalence of T2D was positively associated with boron, calcium and silver, and inversely associated with indium, lead and magnesium (P<0.05). We found no statistical evidence for associations between blood levels of arsenic, bromine, cadmium, cesium, chromium, copper, gallium, gold, manganese, mercury, molybdenum, nickel, rubidium, selenium, strontium, tantalum, thallium, tin and zinc and T2D prevalence. After corrections for multiple testing, associations remained significant for calcium and lead (Q<0.05), and borderline significant for magnesium, silver and boron. With increasing disease duration, higher calcium levels were observed (P<0.05). This study suggests an association between prevalent T2D and blood levels of boron, calcium, indium, lead, magnesium and silver.

The Correlation between Dietary Selenium Intake and Type 2 Diabetes: A Cross-Sectional Population-Based Study on North Chinese Adults

“…However, some studies reported a nonsignificant association between Se and T2D [11,12]. A cross-sectional survey on the Nord-Trondelag Health Survey found no evidence for the significant association of serum Se and T2D by analyzing the trace elements status in the blood of diabetic patients [13]. In contrast, other reports have significantly proved a positive association between Se and T2D [14,15].…”

The Relationship between Dietary, Serum and Hair Levels of Minerals (Fe, Zn, Cu) and Glucose Metabolism Indices in Obese Type 2 Diabetic Patients

“…Recently, the HUNT3 study investigated the relationship between 25 elements and type 2 diabetes [ 7 , 8 ]. The authors concluded that elements such as bromine, cadmium, chromium, iron, nickel, silver and zinc may have played a significant role in the development of diabetes in newly diagnosed type 2 diabetic patients [ 7 ].…”

“…The authors concluded that elements such as bromine, cadmium, chromium, iron, nickel, silver and zinc may have played a significant role in the development of diabetes in newly diagnosed type 2 diabetic patients [ 7 ]. In another study by this team [ 8 ], the prevalence of diabetes was positively correlated with the content of some elements (e.g. boron, calcium and silver) in whole blood but there were no correlations with zinc and copper [ 8 ].…”

“…In another study by this team [ 8 ], the prevalence of diabetes was positively correlated with the content of some elements (e.g. boron, calcium and silver) in whole blood but there were no correlations with zinc and copper [ 8 ]. It is noteworthy that all these correlations referred to the concentrations of elements in the whole blood, which did not reflect the mineral body status.…”

Impact of Labile Zinc on Heart Function: From Physiology to Pathophysiology

“…Recent clinical studies focusing on population-based groups demonstrated that there are conflicting results associated with zinc deficiency and related symptoms in different populations [ 42 , 43 , 44 ]. Moreover, some studies showed a positive correlation between serum zinc and type 2 diabetes risks in either middle-aged and older Finnish men or the Norwegian population as well as in development of liver fibrosis in the Miami adults [ 45 , 46 , 47 , 48 ]. Additionally, Kunutsor and Laukkanen [ 49 ] performed a population-based cohort study in the same country and, due to their data, they suggested that a higher serum zinc concentration is positively and independently associated with incident hypertension in men.…”