Trace elements and ALAD gene polymorphisms in general population from three uranium legacy sites – A case study in Kyrgyzstan

Stajnko, Anja; Tuhvatshin, Rustam; Suranova, G.; Mazej, Darja; Šlejkovec, Zdenka; Falnoga, Ingrid; Krušič, Žiga; Lespukh, E.; Stegnar, P.

doi:10.1016/j.scitotenv.2019.134427

Cited by 4 publications

(1 citation statement)

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“…ALAD polymorphisms and levels of essential (iron, copper, selenium, and manganese) and toxic trace elements (lead, cadmium, Hg, and arsenic) were tested in a Kyrgyz-stan population of uranium legacy sites. Lead blood variability was associated with ALAD polymorphisms with a slight influence on Hg, arsenic, and selenium levels also observed [31].…”

Section: Discussionmentioning

confidence: 87%

Genetic Polymorphism of Delta Aminolevulinic Acid Dehydratase (ALAD) Gene and Symptoms of Chronic Mercury Exposure in Munduruku Indigenous Children within the Brazilian Amazon

Perini

Silva

Vasconcellos

et al. 2021

IJERPH

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Genetic polymorphisms involved in mercury toxicokinetics and toxicodynamics may be associated with severe mercury toxicity. This study aimed to investigate the impact of an ALAD polymorphism on chronic mercury exposure and the health situation of indigenous children from the Brazilian Amazon. One-hundred-and-three indigenous children (under 15 years old) were included and genotyped (rs1800435) using a TaqMan validated assay. The mean age was 6.6 ± 4.5 years old, 60% were female, 49% presented with anemia, and the mean hair mercury concentration was 7.0 ± 4.5 (1.4–23.9) µg/g, with 49% exceeding the reference limit (≥6.0 µg/g). Only two children were heterozygous ALAD, while the others were all wild type. Minor allele frequency (ALAD G) and heterozygous genotype (ALAD CG) were 1% and 2%, respectively. The two children (12 and 14 years old) with the ALAD polymorphism had mercury levels above the average as well as had neurological symptoms related to chronic mercury exposure, such as visual field alterations, memory deficit, distal neuropathy, and toe amyotrophy. Both children also reported frequent consumption of fish in the diet, at least three times a week. In conclusion, our data confirm that an ALAD polymorphism can contribute to mercury half-life time, harmful effects, and neuropsychological disorders in indigenous children with chronic mercury exposure to gold mining activity.

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Section: Discussionmentioning

confidence: 87%