Trace elements, peripheral blood film, and gene expression status in adolescents living near an industrial area in the Colombian Caribbean Coastline

Manjarres-Suarez, Alejandra; Rosa, J. de la; Gonzalez-Montes, Audreis; Galvis-Ballesteros, Javier; Olívero-Verbel, Jesús

doi:10.1038/s41370-021-00340-6

Cited by 2 publications

(3 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The changes in the environmental status of the bay over time have manifested diverse impacts on ecosystems, biodiversity, and the surrounding population. In relation to the component impact, studies have shown alterations in the physicochemical and microbiological quality of the water [ 126 , 128 , 135 ], changes in fishery species, a risk of economic losses [ 119 , 120 ], the altered health of marine organisms [ 59 , 122 , 125 ], and exposure to marine pollutants in vulnerable communities [ 81 , 82 ]. The progressive evidence of these significant changes and the continuing environmental deterioration of the bay have wider implications that emphasize the urgent need to adopt pollution control and mitigation actions, preserve natural habitats, and preserve the health of both the marine environment and the affected populations.…”

Section: Environmental and Socioeconomic Dynamics In Cartagena Baymentioning

confidence: 99%

“…Loss of habitat; seagrasses' reduction by 63% in the last 25 years [66]; decrease in the coral community [64]; loss of mangroves; reduced connectivity between ecosystems [65,86]; alteration in the condition of fish related to increased infection by parasites [122]; bioaccumulation of organic contaminants and metals in different species [59,[123][124][125]; increased environmental health threats for surrounding populations [81,82]; and the alteration of the physicochemical and microbiological water quality of the bay [115,[126][127][128].…”

Section: Impactsmentioning

confidence: 99%

“…Consequently, pollution assessments in the bay and biomonitoring in different species have revealed bioaccumulation and the negative effects of environmental degradation [ 13 , 59 ]. Several publications have addressed the occurrence of pollutants, biomonitoring approaches, and environmental risks resulting from the continued contamination that has been generated in this area, which is one of the most studied ecosystems in Colombia and the Caribbean [ 79 , 80 , 81 , 82 , 83 ]. Therefore, a need arises to analyze the reported substances, concentrations, risks, and effects on some species, with the objective of providing a synthesis of the status and gaps in the study of Cartagena Bay.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Marine Pollution and Advances in Biomonitoring in Cartagena Bay in the Colombian Caribbean

Romero-Murillo

Gallego

Leignel

2023

Toxics

View full text Add to dashboard Cite

Coastal zones sustain extensive biodiversity, support key processes for ocean dynamics, and influence the balance of the global environment. They also provide resources and services to communities, determine their culture, and are the basis for their economic growth. Cartagena Bay in the Colombian Caribbean is the place of the establishment of one of the country’s main cities, which has a great historical and tourist attraction, and it is also the location of the main commercial port and a great variety of industries. Historically, it has been affected by several environmental impacts and intense pollution. This situation has gained the attention of different researchers, so herein is presented a literature review with a systematic approach using RStudio’s bibliometrix on the presence of pollutants and the impact on biodiversity in recent decades, providing a critical analysis of the state of Cartagena Bay and its future needs to ensure its recovery and conservation. In addition, the socioeconomic dynamics related to the environmental state of Cartagena Bay are presented from the framework drivers, pressures, status, impacts, and responses (DPSIR). The update and critical understanding of the sources, fate, and effects of pollution are important not only for the knowledge of the status of this singular ecosystem but also to encourage future research and entrench evidence to support decision makers’ actions. This review highlights that several pollutants that have been detected exceeding sediment quality guidelines, like As, Cd, Hg, and PAH, are also reported to bioaccumulate and cause damage throughout the trophic levels of the coastal environment. In addition, the potential use of sentinel species and biomarkers for their monitoring is discussed. Finally, the factors that cause pollution and threaten the state of the bay continue to exert pressure and impact; thus, there is a call for the further monitoring of this ecosystem and the strengthening of policies and regulations.

show abstract

Section: Environmental and Socioeconomic Dynamics In Cartagena Baymentioning

confidence: 99%

Section: Impactsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Marine Pollution and Advances in Biomonitoring in Cartagena Bay in the Colombian Caribbean

Romero-Murillo

Gallego

Leignel

2023

Toxics

View full text Add to dashboard Cite

show abstract

DNA methylation is associated with hair trace elements in female adolescents from two vulnerable populations in the Colombian Caribbean

Manjarres-Suarez,

Bozack,

Cardenas

et al. 2024

Environmental Epigenetics

View full text Add to dashboard Cite

Exposure to trace elements influences DNA methylation patterns, which may be associated with disease development. Vulnerable populations, such as adolescents undergoing maturity, are susceptible to the effects of trace element exposure. The aim of this study was to analyze the association of hair trace elements concentration with DNA methylation in a sample from female adolescents living in two communities in the Colombian Caribbean coast. Hair and blood samples were obtained from 45 females, between 13 and 16 years of age. Seventeen trace elements were quantified in hair samples. DNA methylation was measured in leukocytes using the Infinium MethylationEPIC BeadChip. Linear models were employed to identify differentially methylated positions (DMPs) adjusting for age, body mass index, mother’s education, and cell type composition. Among the tested elements, vanadium, chromium, nickel, copper, zinc, yttrium, tin and barium were significantly associated with DMPs (FDR < 0.05), registering 225, 1, 2, 184, 1, 209,189 and 104 hits, respectively. Most of the DMPs were positively associated with trace elements and located in open sea regions. The greatest number of DMPs were annotated to the HOXA3 and FOXO3 genes, related to regulation of gene expression and oxidative stress, respectively. These findings suggest that DNA methylation may be involved in linking exposure to trace elements among female adolescents to downstream health risks.

show abstract

Trace elements, peripheral blood film, and gene expression status in adolescents living near an industrial area in the Colombian Caribbean Coastline

Cited by 2 publications

References 49 publications

Marine Pollution and Advances in Biomonitoring in Cartagena Bay in the Colombian Caribbean

Marine Pollution and Advances in Biomonitoring in Cartagena Bay in the Colombian Caribbean

DNA methylation is associated with hair trace elements in female adolescents from two vulnerable populations in the Colombian Caribbean

Contact Info

Product

Resources

About