Trace Measurement of Phenothiazine Drugs in Tablets by Micellar-Enhanced Fluorophotometric Method

Abstract

It was found that in buffer solution of pH 7.0, the addition of sodium dodecyl sulfate (SDS) to the solution of phenothiazine drugs, such as chlorpromazine, promethazine and trifluoperazine, showed a remarkable enhancement of their fluorescence intensity. A further study proved that the phenothiazine drugs can be determined by fluorophotometric method in micellar system. Under optimal conditions, there was a good linear relationship between fluorescence intensity and phenothiazine compounds concentration, and the detection limit of 3.0 x 10(-8) M chlorpromazine, 3.0 x 10(-8) M promethazine and 1.5 x 10(-8) M trifluoperazine (S/N=3) were also obtained. This method has been used to determine phenothiazine drugs in tablets with satisfactory results.

Electrochemical preparation of a molecularly imprinted polypyrrole modified pencil graphite electrode for the determination of phenothiazine in model and real biological samples

“…More recent methods include spectrophotometric [8,13], polarography [14], voltammetry [14,15], potentiometry [16], high-performance liquid chromatography (HPLC) [17], spectrofluorimetry [18], capillary electrophoresis [19], flow injection analysis [20], etc.…”

Biomimetic sensors of molecularly-imprinted polymers for chlorpromazine determination

“…Most of them imply optical-based methods, namely spectrophotometric [5][6][7][8][9][10][11][12][13][14][15][16][17], fluorimetric [18][19][20][21][22], and turbidimetric [23] procedures that regard several chemical transformations of CPZ. High Performance Liquid Chromatography (HPLC) [24][25][26][27][28][29][30][31][32][33] electrophoresis [34] voltammetric [11,[35][36][37],coloumetric [38], polarographic [39] and spectroelectrochemical [12] procedures have been reported as well.…”

An Indirect Atomic Absorption Spectrophotometric Determination of Trifluoperazine Hydrochloride in Pharmaceuticals

“…Recently, TFPH has been the focus of extensive research, both for the development of rapid and simple methods for its detection and because of its structural properties as a reagent for chemical analysis [3]. Various methods have been employed for the determination of TFPH including titrimetry [4], potentiometry [5], spectrophotometry [6][7][8][9][10][11][12][13], fluorimetry [14], flow injection analysis [15,16], sequential injection analysis [17], high-performance liquid chromatography [18,19] and liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS) [20]. Because of its structural features, TFPH and other phenothiazine derivatives have been used extensively as complexing agents with several metals [1,3,8,[21][22][23][24][25][26].…”