Trace minerals in pregnancy 1. Copper and zinc

Yasodhara, P; Ramaraju, L.A.; Raman, L

doi:10.1016/s0271-5317(05)80146-0

Cited by 40 publications

(22 citation statements)

References 11 publications

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“…The positive correlation found in our study and by others [6,7] between maternal and cord values of serum zinc, and particularly the higher cord serum zinc that we observed in women with serum zinc in the higher quartile, are consistent with findings in the guinea pig [21], In this animal species, maternal-fetal mass transfer of zinc was directly related to maternal plasma zinc concentrations, being non-saturable even in the upper range of physiological levels. This could be due to a more favorable diffusional placental-fetal gra dient of zinc with increasing maternal circu lating zinc concentrations.…”

Section: Effect O F Maternal Serum Zinc Levelssupporting

confidence: 93%

“…Most studies on maternal-fetal transfer of zinc have related maternal and cord serum zinc, observing either a significant correlation [6,7] or no correlation [8][9][10], A few studies have measured maternal serum zinc in rela tion to other maternal indices of zinc status [11][12][13] and/or to placental zinc [12,14] and cord serum components [4] in normal preg nancies, but the physiological significance of variations in serum zinc in healthy pregnant women is still unclear.…”

Section: Introductionmentioning

confidence: 99%

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Maternal, Placental and Cord Zinc Components in Healthy Women with Different Levels of Serum Zinc

Zapata

Melo

Donangelo³

1997

Neonatology

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Serum zinc is known to decrease during pregnancy, but the range of individual values at the end of normal gestation may be considerably large, with uncertain physiological significance in terms of maternal zinc status and maternal-fetal transfer of zinc. In this study we compared several maternal and cord blood indices of zinc status, placental zinc, placental metallothionein and the relationship between maternal, cord and placental components, in 40 healthy pregnant women at delivery with different levels of serum zinc. Subjects were divided into three groups according to serum zinc using as cutoff points the lower and upper quartile values [LZn, < 7.6 µmol/l (n = 10); MZn, 7.6–10.7 µmol/l (n = 20), and HZn, > 10.7 µmol/l (n = 10)]. Habitual zinc intakes were similar in all groups (average 11.5 mg/day). Considering all women, maternal serum and erythrocyte zinc correlated significantly (r = 0.40; p = 0.021). Maternal erythrocyte zinc was higher (p < 0.01) in HZn compared to the other groups. Maternal and cord values of serum zinc correlated significantly (r = 0.43; p = 0.006). Cord serum zinc values were very similar in LZn and MZn but were higher (p < 0.01) in HZn. Cord erythrocyte zinc levels were similar in all groups and about 20–25% of the maternal values. Cord erythrocyte metallothionein levels were also similar in all groups and similar to maternal values. Comparing the percentage distribution of zinc in maternal and cord serum fractions, major differences were observed in HZn, with zinc in albumin fraction being 70% in cord compared to 56% in maternal serum. There was a higher (p < 0.01) percentage of zinc bound to α₂-macroglobulin fraction in maternal serum of HZn compared to maternal serum of the other groups. Maternal and cord zinc in the albumin fractions correlated significantly (r = 0.48; p = 0.002) particularly in HZn (r = 0.71; p < 0.021). Placental zinc correlated negatively (r = ––0.34; p = 0.035) with zinc in the maternal α₂-macroglobulin fraction, but did not relate to placental metallothionein, which had similar levels in all groups (average 0.28 nmol/g wet tissue). Placental zinc levels were lower (p < 0.01) in HZn. Our results indicate that high levels of maternal serum zinc in healthy women at delivery may be related to maternal tissue zinc redistribution that could favor diffusional components of maternal-fetal transfer of zinc.

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Section: Effect O F Maternal Serum Zinc Levelssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Maternal, Placental and Cord Zinc Components in Healthy Women with Different Levels of Serum Zinc

Zapata

Melo

Donangelo³

1997

Neonatology

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“…A balanced diet is not available to every human and most of the time there is a lack of information on dietary intake. Consequently, cases of Zn deficiency are frequently reported (Prasad, 1988), especially if Zn demands are increased due to growth or pregnancy (Yasodhara et al 1991). The development of diagnostic tools which allow easy and accurate assessment of Zn status is essential.…”

Section: Zinc Homeostasismentioning

confidence: 99%

Biology of Zinc and Biological Value of Dietary Organic Zinc Complexes and Chelates

1994

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Bone 113 Brain 70 Heart 96 Kidney 141 Liver 151 Red muscle 137 Mixed muscle 89 White muscle 67 Pancreas 161 Spleen 107 Hair 20 1 Skin 28 Erythrocytes (pg/g packed cells) 7.7 Tissuesb Integumentsb a Data compiled from Hoekstra et al. (1956, 1967), Cassens et al. (1967), Miller et al. (l968), Crofton et al. (1983) and Zhou et al. (1994). Data of leucocytes, tissues and integuments are expressed as p.p.m. on a DM basis.

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“…Copper (Cu), for example, is an essential mineral element of particular importance, especially early in life, for the development and maintenance of myelin [7]. Clinical manifestations of Cu deficiency are well characterized, and high Cu intake alters genetic control systems, leading to liver damage in infants [8].…”

Section: Introductionmentioning

confidence: 99%

Influence of cadmium and copper on tissue element levels of pregnant rats

et al. 2007

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AbstractIn the current study, we examined the effects of Cd on Cd, Cu, Zn and Fe levels in placenta and maternal and fetal plasma and tissues, the placental weight, total fetal and maternal body weights, and fetal and maternal tissue weights during pregnancy. A total of 21 adult female rats were treated during gestation with drinking water containing one of the following: 70 mg/L of CdCl2, a combination of 70 mg/L of CdCl2 and 70 mg/L of CuSO4, or no addition (control). Placenta Cu and Fe levels, fetal liver and kidney Cu levels, and fetal liver tissue weights were lower in the group administered Cd than in the control group. Also, Cd levels in the placenta, maternal and fetal liver, and maternal kidney were higher in the group treated with Cd than in controls. In the group administered both Cd and Cu, fetal body and tissue weights did not change, but Cd levels in the placenta, maternal and fetal liver, and maternal kidneys were higher than in controls. Zn and Fe levels in the maternal kidney and fetal liver were also lower in this group. Cd exposure during pregnancy resulted in Cd accumulation in maternal and fetal tissues during pregnancy and a decrease in the total weight of fetuses, and the combination of Cd and Cu caused some changes in the both maternal and fetal levels of Cu, Zn, and Fe, but it did not cause changes in the total fetal body weight or the weights of individual tissues.

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Trace minerals in pregnancy 1. Copper and zinc

Cited by 40 publications

References 11 publications

Maternal, Placental and Cord Zinc Components in Healthy Women with Different Levels of Serum Zinc

Maternal, Placental and Cord Zinc Components in Healthy Women with Different Levels of Serum Zinc

Biology of Zinc and Biological Value of Dietary Organic Zinc Complexes and Chelates

Influence of cadmium and copper on tissue element levels of pregnant rats

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