Trace minerals status and antioxidative enzyme activity in dogs with generalized demodecosis

Beigh, S.A.; Soodan, J.S.; Singh, Ranjit; Khan, Azmat Alam

doi:10.1016/j.vetpar.2013.08.001

Cited by 8 publications

(6 citation statements)

References 38 publications

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“…Neutrophilia with corresponding lymphopenia were also reported by Shyma and Vijaykumar (2011);Beigh et al, (2013) and Thapa and Sarkar (2018). Statistically significant (P<0.01) neutrophilia may be attributed to the cell injury which in turn caused the release of substances such as leukotrien and leukocytosis promoting factors from the blood into the injured areas resulting in release of more neutrophils into the blood stream.…”

Section: Resultssupporting

confidence: 61%

“…All the biochemical parameters viz. ALT, AST, BUN, Creatinine, serum glucose, total protein and Albumin were estimated by using Automated serum biochemistry Analyzer (IDEXX Vet test chemistry analyzer) These findings of present investigation were in accordance with that of Nair and Nauriyal (2007); Gera et al, (2009) and Beigh et al, (2013). The decreased hematological indices (Hb and TEC) recorded in the present observations might be due to the prolonged reduced appetite and/or blood loss from scratching and inflammatory response of the body due to these infections (Sharma et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Haemato-Biochemical Alterations in Dogs Affected with Superficial Pyoderma

Khinchi¹,

Sharma²,

Goklaney³

et al. 2019

Int.J.Curr.Microbiol.App.Sci

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Section: Resultssupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Haemato-Biochemical Alterations in Dogs Affected with Superficial Pyoderma

Khinchi¹,

Sharma²,

Goklaney³

et al. 2019

Int.J.Curr.Microbiol.App.Sci

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“…Oxidative stress may be involved in several pathological conditions in farm animals, such as thermal and physical discomfort, injuries [ 5 ], colitis [ 6 ], and sepsis [ 7 ] in pigs, pneumonic pasteurellosis in sheep [ 8 ], pneumonia in foals [ 9 ], and demodicosis in dogs [ 10 ]. High-producing dairy cows are likely subject to altered redox balance due to high metabolic rates and physiological adaptations [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Protection of Bovine Mammary Epithelial Cells from Hydrogen Peroxide‐Induced Oxidative Cell Damage by Resveratrol

Jin

Wang

Liu

et al. 2015

Oxidative Medicine and Cellular Longevity

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The mammary epithelial cells (MECs) of high-producing dairy cows are likely to be subject to oxidative stress (OS) due to the intensive cell metabolism. The objectives of this study were to investigate the cytoprotective effects of resveratrol against hydrogen peroxide- (H2O2-) induced OS in cultured bovine MECs (MAC-T). Pretreatment of MAC-T cells with resveratrol could rescue the decrease in cell viability and resulted in lower intracellular reactive oxygen species (ROS) accumulation after H2O2 exposure. Resveratrol helped MAC-T cells to prevent H2O2-induced endoplasmic reticulum stress and mitochondria-related cell apoptosis. Moreover, resveratrol induced mRNA expression of multiple antioxidant defense genes in MAC-T cells under normal/oxidative conditions. Nuclear factor erythroid 2-related factor 2 (Nrf2) was required for the cytoprotective effects on MAC-T cells by resveratrol, as knockdown of Nrf2 significantly abolished resveratrol-induced cytoprotective effects against OS. In addition, by using selective inhibitors, we further confirmed that the induction of Nrf2 by resveratrol was mediated through the prolonged activation of PI3K/Akt and ERK/MAPK pathways but negatively regulated by p38/MAPK pathway. Overall, resveratrol has beneficial effects on bovine MECs redox balance and may be potentially used as a therapeutic medicine against oxidative insult in lactating animals.

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“…A similar decrease in SOD activity was observed by Radin et al (2015) in Saanen goats and Jimoh et al (2019) in West African dwarfs. Polycarp et al (2016) reported that increased NEFA significantly decreases the expression and activity of SOD and causes more free radical production which may lead to overutilization of SOD (Beigh et al, 2013;Senoh et al, 2019). Also, increased MDA activity has been found to cause inactivation of antioxidant activity including SOD leading to increased levels of superoxides, hydroxyl radicals, and H 2 O 2 which are inhibitory to the activity of SOD (Beigh, Soodan, Singh, et al, 2014;Kakkar et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

“…The body maintains the redox balance, through enzymatic and non‐enzymatic antioxidants that work together to keep the ROS production at low levels (Giorgio et al, 2020). Trace elements like copper and zinc play an important part in oxidant/antioxidant balance by serving as activators of enzyme systems or as part of organic compounds that play an active role in oxidative stress (Beigh et al, 2013; Fadlalla et al, 2020). Measuring malondialdehyde (MDA), a degradation product of lipid peroxidation, along with enzymatic antioxidants and trace elements like zinc and copper levels may give more accurate information on oxidative stress levels (Beigh et al, 2016; Radin et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Effect of parity on non‐esterified fatty acid, oxidant/antioxidant status, and zinc and copper levels around periparturient period in Beetal goats of Himalayan Region

Singh¹,

Singh²,

Beigh

2022

Animal Physiology Nutrition

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The study was conducted to evaluate the effect of parity and physiological status on non‐esterified fatty acid (NEFA), oxidative stress, and zinc and copper levels among the Beetal breed of goat. Thirty dual‐purpose Beetal goats reared under the semi‐intensive system were selected and based on parity were divided into three groups with 10 animals each viz. Early parity (EP; ≤2 parity), mid parity (MP; 3–6 parity), and late parity (LP; ≥7 parity). Blood samples were collected 3 weeks and 1 week pre‐kidding followed by 1, 2, 4, and 8 weeks post‐kidding for the estimation of NEFA, oxidant (malondialdehyde [MDA], antioxidant (superoxide dismutase [SOD], catalase [CAT], glutathione [GSH], glutathione peroxidase [GSH‐Px], and glutathione S‐transferase [GST]), and zinc and copper levels. Significant (p < 0.01) increase was observed in NEFA and MDA levels as the goats approached kidding and continued till 2 weeks post‐kidding in MP and LP and 1 week post‐kidding in EP goats. Significant decrease in SOD (p < 0.05), CAT (p < 0.05), GSH‐Px (p < 0.01), GSH (p < 0.01), and GST (p < 0.05) activities were observed as goats approached kidding and continued to decrease up to 2 weeks post‐kidding. Zinc and copper levels showed a significant decline from 3 weeks pre‐kidding to 2 weeks post‐kidding in MP and LP and 1 week post‐kidding in EP goats. A significant effect of parity was observed on MDA (p < 0.05), GSH (p < 0.05), and GSH‐Px (p < 0.05) activities only; however, parity × sampling time interaction was observed in all the parameters. Findings highlight a different metabolic, trace mineral (zinc and copper), and oxidative response around the periparturient period in Beetal goats, with the EP goats, responding first to increased metabolic and oxidative stress and also first to recover from oxidant/antioxidant imbalance.

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Trace minerals status and antioxidative enzyme activity in dogs with generalized demodecosis

Cited by 8 publications

References 38 publications

Haemato-Biochemical Alterations in Dogs Affected with Superficial Pyoderma

Haemato-Biochemical Alterations in Dogs Affected with Superficial Pyoderma

Protection of Bovine Mammary Epithelial Cells from Hydrogen Peroxide‐Induced Oxidative Cell Damage by Resveratrol

Effect of parity on non‐esterified fatty acid, oxidant/antioxidant status, and zinc and copper levels around periparturient period in Beetal goats of Himalayan Region

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