Traceable Self‐Assembly of Laser‐Triggered Cyanine‐Based Micelle for Synergistic Therapeutic Effect

Chen, Yuan‐I; Peng, Cheng‐Liang; Lee, Pei-Chi; Tsai, Ming-Hsien; Lin, Chun‐Yen; Shih, Ying-Hsia; Wei, Min-Feng; Luo, Tsai-Yueh; Shieh, Ming‐Jium

doi:10.1002/adhm.201400729

Cited by 24 publications

(17 citation statements)

References 40 publications

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“…In one approach, cyanine served as a scaffold to link hydrophobic mPEG and hydrophilic poly ( ε -caprolactone) (PCL) [ 91 ]. The mPEG-Cy-PCL conjugate ( 41 ) could self-assemble into micelle, during which doxorubicin was encapsulated inside the hydrophobic ( Fig.…”

Section: Cyanine Conjugates As Nanocarriersmentioning

confidence: 99%

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Cyanine conjugates in cancer theranostics

Yang

Zhou

Yue

et al. 2021

Bioactive Materials

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Cyanine is a meritorious fluorogenic core for the construction of fluorescent probes and its phototherapeutic potential has been enthusiastically explored as well. Alternatively, the covalent conjugation of cyanine with other potent therapeutic agents not only boosts its therapeutic efficacy but also broadens its therapeutic modality. Herein, we summarize miscellaneous cyanine–therapeutic agent conjugates in cancer theranostics from literature published between 2014 and 2020. The application scenarios of such theranostic cyanine conjugates covered common cancer therapeutic modalities, including chemotherapy, phototherapy and targeted therapy. Besides, cyanine conjugates that serve as nanocarriers for drug delivery are introduced as well. In an additional section, we analyze the potential of these conjugates for clinical translation. Overall, this review is aimed to stimulate research interest in exploring unattempted therapeutic agents and novel conjugation strategies and hopefully, accelerate clinical translation in this field.

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Section: Cyanine Conjugates As Nanocarriersmentioning

confidence: 99%

“…Reprinted with permission from Ref. [ 91 ]. (B) Schematic representation of the gemcitabine-loaded bilayer nanovesicles self-assembled from conjugate 42 (left) and TEM images of the empty nanovesicles (right).…”

Section: Cyanine Conjugates As Nanocarriersmentioning

confidence: 99%

Cyanine conjugates in cancer theranostics

Yang

Zhou

Yue

et al. 2021

Bioactive Materials

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“…The non-self-degradable (ND) copolymers, methoxyPolyEthylene Glycol-PolyCaproLactone, (mPEG-PCL) was synthesized as described in our earlier research (Chen et al, 2015). The selfdegradable (SD) copolymers, methoxyPolyEthylene Glycol-S-S-PolyCaproLactone (mPEG-S-S-PCL) was primarily obtained via two chemical reactions.…”

Section: Synthesis Of the Self-degradable Non-self-degradable Copolymentioning

confidence: 99%

A Targeting Self-breakable Agent for Increased Efficacy of Chemotherapeutic Drugs against Caco2 Cells

Tsai

Shieh

Peng

2016

Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies

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Many types of nano-sized anti-cancer agents that could increase efficacy of chemotherapeutic drugs have been created and developed in colon cancer treatment over years. Moreover, with the intention of achieving the ideal chemotherapeutic efficacy, nano-sized anti-cancer agents were further designed to have specific functions, efficiently killing colon cancer cells. Our research team focused on two important functions in designing nano-sized agents, controlled drug release and targeting functions. Thus, targeting functional micelles which entrapped chemotherapeutic drug, 7-ethyl-10-hydroxy-camptothecin (SN38) were designed in nano-size and possessed disulfide bonds in this study. In particular, Self-Breakable SN38-loaded micelles (SN/38 micelles), Non-Breakable micelles SN38-loaded (NB/38 micelles) and Folate-targeting Self-Breakable SN38-loaded micelles (FSB/38 micelles) were prepared and tested to the designed agents. The results showed that the folate-decorated functional micelles with disulfide bonds could be an effective chemotherapeutic agent for colon cancer treatment.

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“…Multifunctional self-assembled nanostructures such as micelles and vesicles formed by block polymers that contain both fluorescent and therapeutic agents are important for applications such as imaging-guided therapy or so-called theranostics [1,2,3,4,5,6,7,8,9,10,11]. One of the conventional approaches to this end is to encapsulate organic fluorophores and therapeutic agents such as anticancer drugs into the same or different compartments of block copolymer self-assemblies [12,13,14,15,16,17,18,19]. Challenges that these approaches often face, however, include aggregation-caused fluorescence quenching, photobleaching of organic chromophores, and leaching of the organic chromophores from the polymer matrices.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Nanostructures of Red Fluorescent Amphiphilic Block Copolymers as Both Imaging Probes and Drug Carriers

2018

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We report a red-fluorescent drug delivery system formed by biodegradable and biocompatible amphiphilic A-B-A block copolymers. Each polymer consists of a red fluorescent dye covalently bonded in the middle of hydrophobic block (B) of polylactone, tethered at both ends with poly[(oligo ethylene glycol) methyl ether methacrylate] (POEGMA) as the hydrophilic block. Two types of polylactones, i.e., semicrystalline poly(ε-caprolactone) (PCL) and amorphous poly(δ-decalactone) (PDL), respectively, were incorporated as the hydrophobic segment in the block copolymers. Using transmission electron microscopy, we characterized the self-assembled nanostructures formed by these amphiphilic block copolymers in mixtures of water/tetrahydrofuran or water/dimethylformamide. All of these polymers remained highly fluorescent in water, although some extent of aggregation-induced fluorescence quenching was still observed. Among the three types of polymers presented here, the polymer (RPO-3) containing an amorphous block of PDL showed the highest drug-loading capacity and the largest extent of drug release in acidic media. RPO-3 micelles loaded with doxorubicin as a model of anticancer drug showed sustainable intracellular release and cytotoxicity against HeLa cells.

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Traceable Self‐Assembly of Laser‐Triggered Cyanine‐Based Micelle for Synergistic Therapeutic Effect

Cited by 24 publications

References 40 publications

Cyanine conjugates in cancer theranostics

Cyanine conjugates in cancer theranostics

A Targeting Self-breakable Agent for Increased Efficacy of Chemotherapeutic Drugs against Caco2 Cells

Self-Assembled Nanostructures of Red Fluorescent Amphiphilic Block Copolymers as Both Imaging Probes and Drug Carriers

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