Tracheal intubation in paediatric surgeries without muscle relaxation using magnesium sulphate as an adjuvant

Salah, Dina; Shorbagy, Mohammed S; Saleh, Mohamed

doi:10.4103/1687-7934.139569

Cited by 2 publications

(10 citation statements)

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“…There were no cases of ‘clinical hypermagnesemia’ related to treatment overdosing (almost exclusively in patients with renal dysfunction). Therefore, MgSO 4 appears to present an optimal safety profile .…”

Section: Therapeutic Index and Cost‐effectivenessmentioning

confidence: 97%

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Magnesium sulfate in pediatric anesthesia: the Super Adjuvant

Rebollar

Palacios

Guerrero

et al. 2017

Pediatric Anesthesia

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Magnesium is an essential chemical element in all organisms, intervening in most cellular enzymatic reactions; thus, its importance in homeostasis and as a therapeutic tool in highly challenging patients such as pediatrics. The primary purpose of this paper was to review the role of magnesium sulfate as an adjuvant drug in pediatric anesthesia. This compound already has the scientific backing in certain aspects such as analgesia or muscle relaxation, but only theoretical or empirical backing in others such as organ protection or inflammation, where it seems to be promising. The multitude of potential applications in pediatric anesthesia, its high safety, and low cost make magnesium sulfate could be considered a Super Adjuvant.

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Section: Therapeutic Index and Cost‐effectivenessmentioning

confidence: 97%

“…There were no cases of 'clinical hypermagnesemia' related to treatment overdosing (almost exclusively in patients with renal dysfunction). Therefore, MgSO 4 appears to present an optimal safety profile (2,5,(17)(18)(19)(20)31,(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)48,49,59,(68)(69)(70)(71)(72).…”

Section: Therapeutic Index and Cost-effectivenessmentioning

confidence: 99%

Magnesium sulfate in pediatric anesthesia: the Super Adjuvant

Rebollar

Palacios

Guerrero

et al. 2017

Pediatric Anesthesia

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“…4,8,9 Magnesium juga menghambat pelepasan katekolamin sehingga dapat menurunkan respons hemodinamik yang terjadi akibat stimulasi adrenergik pada saat dilakukan tindakan intubasi. 10 Tujuan penelitian ini adalah mengkaji efek pemberian magnesium sulfat 45 mg/ kgBB terhadap kualitas intubasi dan respons hemodinamik pada tindakan dengan intubasi endotrakeal tanpa obat pelumpuh otot. Hasil penelitian ini diharapkan dapat memberi manfaat bagi pasien yang akan menjalani prosedur pembedahan dengan durasi singkat, membutuhkan identifikasi saraf, atau memiliki kontraindikasi terhadap pemberian obat pelumpuh otot.…”

Section: Pendahuluanunclassified

“…Hasil penilaian setiap komponen tersebut membagi kondisi intubasi endotrakeal ke dalam tiga klasifikasi, yaitu kondisi intubasi sangat baik, baik, dan buruk. 4,8,10,11 Kondisi intubasi diklasifikasikan sangat baik apabila didapatkan seluruh komponen penilaian dari skor Copenhagen sangat baik. Kondisi intubasi diklasifikasikan baik apabila terdapat komponen penilaian sangat baik atau baik.…”

Section: Subjek Dan Metodeunclassified

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Efek Pemberian Magnesium Sulfat 45 Mg/kgBB terhadap Kualitas Tindakan Intubasi Endotrakeal Tanpa Obat Pelumpuh Otot dan Perubahan Respons Hemodinamik

Fatima¹,

Pradian²,

Yadi³

2019

jap

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Intubasi endotrakeal merupakan tindakan berisiko tinggi yang menghasilkan stimulasi adrenergik. Intubasi endotrakeal menggunakan obat pelumpuh otot sebagai standar baku dapat menimbulkan efek samping berupa reaksi anafilaksis dan rekurisasi pascabedah. Intubasi endotrakeal tanpa obat pelumpuh otot ditujukan untuk prosedur pembedahan yang singkat, membutuhkan identifikasi saraf, dan terdapat kontraindikasi pemberian obat pelumpuh otot. Tujuan penelitian ini mengkaji pemberian magnesium sulfat 45 mg/kgBB terhadap kualitas intubasi dan respons hemodinamik pada tindakan intubasi endotrakeal tanpa obat pelumpuh otot. Penelitian ini merupakan penelitian eksperimental secara acak buta ganda yang dilakukan secara prospektif terhadap 42 subjek penelitian yang menjalani prosedur pembedahan dengan anestesi umum di Rumah Sakit Umum Pusat Dr. Hasan Sadikin, Bandung pada bulan April–Juli 2018. Pada penelitian ini, data numerik diuji dengan uji t tidak berpasangan, sedangkan data kategorik diuji dengan uji chi-square dan Mann Whitney. Hasil penelitian menunjukkan kualitas intubasi endotrakeal tanpa obat pelumpuh otot lebih baik dengan disertai penurunan respons hemodinamik pada kelompok yang diberikan magnesium sulfat 45 mg/kgBB dibanding dengan kelompok kontrol (p<0,05). Simpulan, pemberian magnesium sulfat 45 mg/kgBB meningkatkan kualitas tindakan intubasi endotrakeal tanpa obat pelumpuh otot yang dinilai menggunakan skor Copenhagen dan menurunkan respons hemodinamik pada tindakan intubasi endotrakeal tanpa obat pelumpuhotot.Effect of 45 mg/kgBW Magnesium Sulphate on Quality of Endotracheal Intubation without Neuromuscular Blocking Agents and Change in Hemodynamic ResponsesEndotracheal intubation is a high-risk procedure that can stimulate adrenergic response. Neuromuscular blocking agent is used to facilitate endotracheal intubation but it has undesirable effects such as anaphylactic reaction and postoperative recurarization. This technique is indicated for short surgical procedures, requires nerve identification, and is contraindicated for neuromuscular blocking agent. The purpose of this study was to review the effect of 45 mg/kgBW magnesium sulphate to the quality of intubation and hemodynamic responses in endotracheal intubation without neuromuscular blocking agent. This was a prospective double blind experimental study conducted on 42 research subjects underwent surgical procedures under general anesthesia in Dr. Hasan Sadikin General Hospital, Bandung in the period of April–July 2018. In this study, numerical data were tested by unpaired t test. Categorical data were tested by chi-square and Mann Whitney tests. The results showed that the quality of endotracheal intubation without neuromuscular blocking agent improved with minimum hemodynamic changes in the group receiving 45 mg/kgBW magnesium sulphate (p<0.05). It is concluded that 45 mg/kgBW magnesium sulphate improves intubating quality assessed using Copenhagen score and decreases hemodynamic responses to endotracheal intubation without neuromuscular blocking agents.

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Tracheal intubation in paediatric surgeries without muscle relaxation using magnesium sulphate as an adjuvant

Cited by 2 publications

References 1 publication

Magnesium sulfate in pediatric anesthesia: the Super Adjuvant

Magnesium sulfate in pediatric anesthesia: the Super Adjuvant

Efek Pemberian Magnesium Sulfat 45 Mg/kgBB terhadap Kualitas Tindakan Intubasi Endotrakeal Tanpa Obat Pelumpuh Otot dan Perubahan Respons Hemodinamik

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