Tracheobronchopathia osteochondroplastica presenting as an isolated nodule in the right upper lobe bronchus with upper lobe collapse

Doshi, Harikrishna; Thankachen, Roy; Philip, Madhu Andrew; Kurien, Susy; Shukla, Vinayak; Korula, Roy John

doi:10.1016/j.jtcvs.2005.01.020

Cited by 24 publications

(26 citation statements)

References 6 publications

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“…The typical bronchoscopic findings were described vividly as a cobblestone, a beaded or stalactitic cave, a rock garden, or a veritable mountainscape appearance [26], [39]. Biopsy of TO lesions sometimes can be a challenge due to the hard consistency of the bone nodules [26].…”

Section: Discussionmentioning

confidence: 99%

A Clinical Study of Tracheobronchopathia Osteochondroplastica: Findings from a Large Chinese Cohort

Zhu

Huang

et al. 2014

PLoS ONE

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Background and Study AimsTracheobronchopathia osteochondroplastica (TO) is an uncommon disease of the tracheobronchial system that leads to narrowing of the airway lumen from cartilaginous and/or osseous submucosal nodules. The aim of this study is to perform a detailed review of this rare disease in a large cohort of patients with TO proven by fiberoptic bronchoscopy from China.Patients and MethodsRetrospective chart review was performed on 41,600 patients who underwent bronchoscopy in the Department of Respiratory Medicine of Changhai Hospital between January 2005 and December 2012. Cases of TO were identified based on characteristic features during bronchoscopic examination.Results22 cases of bronchoscopic TO were identified. Among whom one-half were male and the mean age was 47.45±10.91 years old. The most frequent symptoms at presentation were chronic cough (n = 14) and increased sputum production (n = 10). Radiographic abnormalities were observed in 3/18 patients and findings on computed tomography consistent with TO such as beaded intraluminal calcifications and/or increased luminal thickenings were observed in 18/22 patients. Patients were classified into the following categories based on the severity of bronchoscopic findings: Stage I (n = 2), Stage II (n = 6) and Stage III (n = 14). The result that bronchoscopic improvement was observed in 2 patients administered with inhaled corticosteroids suggested that resolution of this disease is possible.ConclusionsTO is a benign disease with slow progression, which could be roughly divided into 3 stages on the basis of the characteristic endoscopic features and histopathologic findings. Chronic inflammation was thought to be more important than the other existing plausible hypotheses in the course of TO. Inhaled corticosteroids might have some impact on patients at Stage I/II.

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Section: Discussionmentioning

confidence: 99%

A Clinical Study of Tracheobronchopathia Osteochondroplastica: Findings from a Large Chinese Cohort

Zhu

Huang

et al. 2014

PLoS ONE

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“… 9 , 10 There is bony tissue, which is often cartilaginous, adjacent to the cartilaginous rings. Microscopically, the benign bony-cartilaginous tissue grows and replaces the bronchial submucosa and compresses the mucous glands.…”

Section: Discussionmentioning

confidence: 99%

Tracheobronchopathia osteochondroplastica

et al. 2017

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Tracheobronchopathia osteochondroplastica is a rare benign disease, of unknown cause, characterized by numerous sessile, cartilaginous, or bony submucosal nodules distributed throughout the anterolateral walls, projecting into the laryngotracheobronchial lumen. In general, tracheobronchopathia osteochondroplastica is diagnosed incidentally during bronchoscopy or autopsy and is not associated with a specific disease. We report the case of a male patient who was diagnosed with tracheobronchopathia osteochondroplastica via bronchoscopy and biopsy.

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“…Changes to the airway clearance help in disease onset after the persistent inflammatory process, resulting in repetitive infections. Bacteria such as Klebsiella ozenae or Botryomicosis have been shown in OT cases after chronic infection; however without an established correlation 8,11 . Clinically, 13-50% of the patients may remain asymptomatic.…”

Section: Discussionmentioning

confidence: 99%

Traqueobroncopatia osteocondroplástica: relato de 2 casos e revisão bibliográfica

Pinto¹,

Silva²,

Perfeito³

et al. 2010

Braz. j. otorhinolaryngol. (Impr.)

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Ost eochondroplastic tracheobronchopathy (OT) is a rare benign disorder of the lower part of the trachea and the upper part of the main bronchus characterized by numerous submucosal calcified nodules, sessile, cartilaginous and/or osseous with laryngotracheobronchial lumen projection. There are less than 400 cases reported in the word literature.Aim: to report and discuss 02 cases of OT with a bibliography review. Materials and Methods:we report on 02 cases with bibliography revision from MEDLINE, LILACS and PUBMED data.Study design: observational, descriptive, case reports.Conclusion: the symptoms result from airway obstruction, causing dry cough, dyspnea and recurrent respiratory tract infections. The diagnostic hypothesis is established by endoscopy of the upper airway (laryngo-tracheo-bronchoscopy), and the trachea/chest computed tomography is the best image exam to define tracheal nodule alterations. The differential diagnoses are papillomatosis, amyloidosis and sarcoidosis chondrosarcoma hamartoma and calcified paratracheal lymph nodes. There is no specific treatment and the prognosis is good. Surgery is restricted to moderate or severe airway obstructions. Otorhinolaryngologists must include OT in the differential diagnosis of cases of upper airway and tracheobronchial tree suggestive symptoms. Braz J Otorhinolaryngol. 2010;76(6):789-93. BJORL REVIEW ARTICLE

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Tracheobronchopathia osteochondroplastica presenting as an isolated nodule in the right upper lobe bronchus with upper lobe collapse

Cited by 24 publications

References 6 publications

A Clinical Study of Tracheobronchopathia Osteochondroplastica: Findings from a Large Chinese Cohort

A Clinical Study of Tracheobronchopathia Osteochondroplastica: Findings from a Large Chinese Cohort

Tracheobronchopathia osteochondroplastica

Traqueobroncopatia osteocondroplástica: relato de 2 casos e revisão bibliográfica

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