Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit

Bernal, Mario A.; Bordage, M.C.; Brown, Jeremy M. C.; Davídková, Marie; Delage, Erick; Bitar, Ziad El; Enger, Shirin A.; Francis, Z.; Guatelli, Susanna; Ivanchenko, V. N.; Karamitros, Mathieu; Kyriakou, Ioanna; Maigne, Lydia; Meylan, Sylvain; Murakami, K.; Okada, Shogo; Payno, H.; Perrot, Y.; Petrović, Ivan; Pham, Quang-Dung; Ristić-Fira, Aleksandra; Sasaki, Takashi; Štěpán, Václav; Tran, H.N.; Villagrasa, C.; Incerti, S.

doi:10.1016/j.ejmp.2015.10.087

Cited by 417 publications

(401 citation statements)

References 85 publications

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“…Since 2007, Geant4-DNA offers physics processes and models able to describe particle interactions in liquid water at nanometre scale [31][32][33]. This Package currently provides a complete set of models describing the event-by-event electromagnetic interactions of particles (electrons, protons and neutral hydrogen atoms, alpha particles including their charge states) with liquid water (as well as ionisation for a few ions -Li, Be, B, C, N, O, Si and Fe).…”

Section: Physics Modellingmentioning

confidence: 99%

“…In the most recent Geant4 release (10.2), a new improved implementation of this model has been added in order to account for binding-energy thresholds through a re-distribution of the oscillator strength and refinements in the exchange and perturbation corrections to the Born approximation, as described in detail in [35]. Three elastic scattering models are provided, either derived from a full partial wave analysis for the liquid phase, or from the analytical Screened Rutherford theory with a low energy screening parameter derived from data either in nitrogen gas or in gaseous water [31]. Finally, regarding sub-excitation electrons, vibrational excitation is based on the Michaud et al measurements scaled for the liquid phase, and molecular attachement based on experiments by Melton [36].…”

Section: Physics Modellingmentioning

confidence: 99%

“…One of the main goals of the Geant4-DNA Package is to be able to predict early damage to DNA [31,44], taking into account both direct and indirect deleterious actions of ionising radiation on sensitive biological targets. In order to simulate damage to DNA, Geant4-DNA can be utilized following three approaches: (1) the estimation of damage using clustering algorithms, (2) the explicit geometrical modelling of the DNA double helix and associated biological structures of interest, and (3) a mixed approach combining the usage of clustering algorithms with geometrical modelling.…”

Section: Geometrical Models Of Dnamentioning

confidence: 99%

“…They could simulate SSB, DSB and DSB/SSB ratios as a function of incident proton energy close to other simulated and experimental data on cells and plasmids obtained from the literature. While their algorithm was not included in Geant4/Geant4-DNA, Perrot et al followed a similar approach as Francis et al, adapting the algorithm from DBSCAN, and they included this clustering algorithm in the "clustering" Geant4-DNA "extended" example in December 2015 (Geant4 release 10.2), and is described in more detail in [31]. They could predict DSB/SSB ratios as a function of incident proton energy close to values predicted by the PARTRAC code [10] and reproduce the results by Francis et al [46].…”

Section: Clustering Algorithmsmentioning

confidence: 99%

“…Once clusters have been formed, the code scans all clusters once and merge them if their barycenters are separated by less than the maximum distance selected by the user (this is a simplification compared to the DBSCAN algorithm and to the code developed by Francis et al). The code can also be used with the most recent Geant4-DNA physics models (see section 2), and it calculates single, complex single and double strand breaks as well as cluster sizes and its performance is illustrated in Bernal et al [31].…”

Section: Clustering Algorithmsmentioning

confidence: 99%

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Review of Geant4-DNA applications for micro and nanoscale simulations

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Emerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-byevent electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis. Since its release, Geant4-DNA has been adopted as an investigational tool in kV and MV external beam radiotherapy, hadron therapies using protons and heavy ions, targeted therapies and radiobiology studies. It has been benchmarked with respect to other track structure Monte Carlo codes and, where available, against reference experimental measurements. While Geant4-DNA physics models and radiolysis modelling functionalities have already been described in detail in the literature, this review paper summarises and discusses a selection of representative papers with the aim of providing an overview of a) geometrical descriptions of biological targets down to the DNA size, and b) the full spectrum of current micro-and nano-scale applications of Geant4-DNA. Disciplines Engineering | Science and Technology Studies Publication DetailsIncerti, S., Douglass, M., Penfold, S., Guatelli, S. & Bezak, E. (2016). Review of Geant4-DNA applications for micro and nanoscale simulations. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 32 (10), 1187-1200. AbstractEmerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-by-event electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis.

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Section: Physics Modellingmentioning

confidence: 99%

Section: Physics Modellingmentioning

confidence: 99%

Section: Geometrical Models Of Dnamentioning

confidence: 99%

Section: Clustering Algorithmsmentioning

confidence: 99%

Section: Clustering Algorithmsmentioning

confidence: 99%

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Review of Geant4-DNA applications for micro and nanoscale simulations

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Metallic nanoparticles irradiated by low‐energy protons for radiation therapy: Are there significant physical effects to enhance the dose delivery?

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Geant4‐DNA track‐structure simulations for gold nanoparticles: The importance of electron discrete models in nanometer volumes

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Improved physics models for gold are necessary to better model the impact of GNPs in radiotherapy via Monte Carlo simulations. We implemented discrete electron transport models for gold in Geant4 that is applicable down to 10 eV including the modeling of the full de-excitation cascade. It is demonstrated that the new model has a significant positive impact on particle transport simulations in gold volumes with submicron dimensions compared to the existing Livermore and Penelope condensed-history models of Geant4.

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Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit

Cited by 417 publications

References 85 publications

Review of Geant4-DNA applications for micro and nanoscale simulations

Review of Geant4-DNA applications for micro and nanoscale simulations

Metallic nanoparticles irradiated by low‐energy protons for radiation therapy: Are there significant physical effects to enhance the dose delivery?

Geant4‐DNA track‐structure simulations for gold nanoparticles: The importance of electron discrete models in nanometer volumes

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