Tracking the multiple-step formation of an iron(III) complex and its application in photodynamic therapy for breast cancer

Zhu, Zhong‐Hong; Hu, Qian; Pan, Hui; Zhang, Yuexing; Xu, Hai‐Bing; Kurmoo, Mohamedally; Huang, Jin; Zeng, Ming

doi:10.1007/s11426-019-9464-1

Cited by 22 publications

(19 citation statements)

References 31 publications

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“…Moreover, we did not observe any emission corresponding to 573 nm (λ max , UV–visible spectra) excitation within the operating wavelength range of the fluorescence spectrophotometer (Figure S24). − The nanocomposite 1 -AuNPs (100 μg/mL) exhibited two emission bands at 564 and 585 nm (λ ex , 350 nm), with a fluorescence quantum yield of 0.018. The fluorescence studies were carried out in 5% DMSO/H 2 O and DMEM (1:9) at pH 7.2 and 298 K (Figure S24 and Table S1).…”

Section: Resultsmentioning

confidence: 99%

Iron(III) Complex-Functionalized Gold Nanocomposite as a Strategic Tool for Targeted Photochemotherapy in Red Light

et al. 2021

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Iron(III)-phenolate/carboxylate complexes exhibiting photoredox chemistry and photoactivated reactive oxygen species (ROS) generation at their ligand-to-metal charge-transfer (LMCT) bands have emerged as potential strategic tools for photoactivated chemotherapy. Herein, the synthesis, in-depth characterization, photochemical assays, and remarkable red light-induced photocytotoxicities in adenocarcinomic human immortalized human keratinocytes (HaCaT) and alveolar basal epithelial (A549) cells of iron(III)-phenolate/carboxylate complex of molecular formula, [Fe(L1)(L2)] (1), where L1 is bis(3,5 di-tert-butyl-2-hydroxybenzyl)glycine and L2 is 5-(1,2-dithiolan-3-yl)-N-(1,10-phenanthroline-5-yl)pentanamide, and the gold nanocomposite functionalized with complex 1 (1-AuNPs) are reported. There was a significant red shift in the UV–visible absorption band on functionalization of complex 1 to the gold nanoparticles (λmax: 573 nm, 1; λmax: 660 nm, 1-AuNPs), rendering the nanocomposite an ideal candidate for photochemotherapeutic applications. The notable findings in our present studies are (i) the remarkable cytotoxicity of the nanocomposite (1-AuNPs) to A549 (IC50: 0.006 μM) and HaCaT (IC50: 0.0075 μM) cells in red light (600–720 nm, 30 J/cm2) while almost nontoxic (IC50 > 500 μg/mL, 0.053 μM) in the dark, (ii) the nontoxicity of 1-AuNPs to normal human diploid fibroblasts (WI-38) or human peripheral lung epithelial (HPL1D) cells (IC50 > 500 μg/mL, 0.053 μM) both in the dark and red light signifying the target-specific anticancer activity of the nanocomposite, (iii) localization of 1-AuNPs in mitochondria and partly nucleus, (iv) remarkable red light-induced generation of reactive oxygen species (ROS: 1O2, •OH) in vitro, (v) disruption of the mitochondrial membrane due to enhanced oxidative stress, and (vi) caspase 3/7-dependent apoptosis. A similar cytotoxic profile of complex 1 was another key finding of our studies. Overall, our current investigations show a new red light-absorbing iron(III)-phenolate/carboxylate complex-functionalized gold nanocomposite (1-AuNPs) as the emerging next-generation iron-based photochemotherapeutic agent for targeted cancer treatment modality.

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Section: Resultsmentioning

confidence: 99%

Iron(III) Complex-Functionalized Gold Nanocomposite as a Strategic Tool for Targeted Photochemotherapy in Red Light

et al. 2021

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“…The structure of an organic ligand usually does not change during the formation of a complex with a specific connection and topological structure via coordination among the organic ligand, coordinating anion and metal ion . In recent years, hydrothermal/solvothermal technology has gradually become an important synthetic means, and a directional construction of new organic frameworks, coordination polymers and coordination molecular clusters has been achieved . Under solvothermal conditions, owing to the effects of temperature and pressure, certain metal ions with strong catalytic ability can further catalyze the reaction of the starting ligand by coordinating under in situ conditions, which will produce several organic compounds that are difficult to build via traditional organic synthesis .…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, solvothermal in situ metal/ligand reactions are called bridges between inorganic and organic reactions . While additional examples of organic ligands involved in coordination during the formation of complexes have been found, these examples are mostly involved in the formation of 3d metal complexes . Lanthanide metal ions have difficulty undergoing complex in situ ligand reactions during the formation of lanthanide complexes owing to their strong coordination ability, strong selectivity of coordination atoms, and complex and varied coordination configurations .…”

Section: Introductionmentioning

confidence: 99%

Temperature‐induced formation of two dinuclear dysprosium complexes with different magnetic properties

Zhu

Wang

et al. 2020

Applied Organom Chemis

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A dinuclear Dy (III) complex [Dy2(L1)2(NO3)4]·2CH3CN (1) (HL1 = 1,3‐bis{[(E)‐pyridin‐2‐ylmethylene]amino}propan‐2‐ol) was obtained via the reaction of 1,3‐diamino‐2‐propanol, 2‐pyridyaldehyde and Dy (NO3)3·6H2O at room temperature. In the structure of complex 1, two Dy (III) ions are in the N4O6 coordination environment provided by NO3− and (L1)−, and both of these ions are in the sphenocorona configuration. [Dy2(L2)2(NO3)4] (2) [HL2 = 2‐(pyridin‐2‐yl)hexahydropyrimidin‐5‐ol] was obtained using the same reaction material only when the reaction temperature was changed to 60°C. Structural analysis of complex 2 showed that the two Dy (III) ions with the same coordination configuration are in the N3O6 coordination environment provided by NO3− and (L2)− and are in the distorted spherical‐capped square antiprism. Surprisingly, HL2 with the parent of bipyridine was synthesized by the Schiff base reaction of 1,3‐diamino‐2‐propanol with 2‐pyridoxaldehyde followed by the ring‐closing reaction catalyzed by Dy (III) ions. Magnetic measurements of the Dy (III) complexes revealed no obvious frequency‐dependent behavior of complex 1. In contrast, complex 2 showed an obvious frequency dependence (Ueff = 0.49 K and τ0 = 6.62 × 10−4 s) under the condition of zero field and a weak double relaxation behavior (Ueff = 9.25 K and τ0 = 9.70 × 10−4 s) at 1500 Oe.

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“…In spite of great progress in medicine, it is always difficult to treat cancer in clinic . Recently, nanomedicine- and nanotechnology-based strategies have been explored and developed for tumor treatment, such as light-triggered photothermal/photodynamic therapy (PTT/PDT), − nanocarrier-based chemotherapy, − and O 2 -dependent radiotherapy, , which have shown remarkable anticancer efficacy. Despite the substantial progress in nanotechnology-mediated tumor therapy, the defects including limited tissues penetration, premature drug leakage, multidrug resistance, and insufficient oxygen supply of solid tumor, especially nonspecificity, which results in undesirable side effects and damages to normal cells, greatly confine their clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Metal–Organic Framework-Integrated Enzymes as Bioreactor for Enhanced Therapy against Solid Tumor via a Cascade Catalytic Reaction

Bai

Peng

Guo

et al. 2019

ACS Biomater. Sci. Eng.

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Emerging natural-enzyme-based nanocatalytic tumor therapy depending on the high catalytic performance of natural enzymes has inspired great research interest in clinical applications. Nevertheless, the natural-enzyme-based catalytic therapy efficiency is seriously hampered by the low operational stability, poor delivery efficiency, and the short lifetime of enzymes. Herein, a bioreactor based on zeolitic imidazolate framework-8 (ZIF-8) was fabricated through one-pot embedding horseradish peroxidase (HRP) and glucose oxidase (Gox) strategy (ZIF-8@Gox/HRP) for synergistic cancer therapy. Notably, the obtained ZIF-8@Gox/HRP can efficiently consume endogenous glucose to generate gluconic acid and H2O2 for starving tumors, and subsequently, H2O2 was decomposed by encapsulated HRP to release high-toxic •OH radicals, inducing cancer cell apoptosis for oxidation therapy. Importantly, in vivo results showed that ZIF-8@Gox/HRP had an impressive tumor-suppression rate based on cascade catalytic reaction. Therefore, this work paves a new avenue to design smart enzyme-based platforms for safe and efficient cancer therapy.

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Tracking the multiple-step formation of an iron(III) complex and its application in photodynamic therapy for breast cancer

Cited by 22 publications

References 31 publications

Iron(III) Complex-Functionalized Gold Nanocomposite as a Strategic Tool for Targeted Photochemotherapy in Red Light

Iron(III) Complex-Functionalized Gold Nanocomposite as a Strategic Tool for Targeted Photochemotherapy in Red Light

Temperature‐induced formation of two dinuclear dysprosium complexes with different magnetic properties

Metal–Organic Framework-Integrated Enzymes as Bioreactor for Enhanced Therapy against Solid Tumor via a Cascade Catalytic Reaction

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