Tracking the transdermal penetration pathways of optimized curcumin-loaded chitosan nanoparticles via confocal laser scanning microscopy

Abdel-Hafez, Salma M.; Hathout, Rania M.; Sammour, Omaima A.

doi:10.1016/j.ijbiomac.2017.10.170

Cited by 104 publications

(66 citation statements)

References 100 publications

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“…32 Obtained data might be indicative of the main route for the nanoparticle dermal penetration through the follicle. This finding agrees with Abdel-Hafez et al 33 These authors have shown that the appendageal route is the main route of penetration of lipid nanoparticles, also demonstrating that being inside the hair follicles is crucial for drug diffusion to deep layers of the skin.…”

Section: Studies Of Interaction Of Nanoparticles and Human Skinsupporting

confidence: 92%

Nanostructured Lipid Carriers Loaded with 17-α-Estradiol Accumulate into Hair Follicles

Silva

Jesus

2020

J. Braz. Chem. Soc.

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To improve 17-α-estradiol targeting in alopecia treatment, a formulation of nanostructured lipid carrier (NLC) prepared by the sonication method was developed. The physicochemical characterization showed an average diameter of 96 ± 15 nm and the average zeta potential of-17 ± 6 mV. In addition, the encapsulation efficiency (EE) of 17-α-estradiol, assessed by ultra-performance liquid chromatography (UPLC) fluorescence, was 99.6 ± 0.3%. Physical stability of NLC stored at room temperature was followed for 42 days through several physicochemical parameters, such as diameter, zeta potential, pH and EE. No changes were observed in the physicochemical parameters during this period, demonstrating the potential of NLC as a delivery system of 17-α-estradiol. NLC dermal penetration, investigated by Franz diffusion cell and confocal microscopy using rhodamine-labeled NLCs, showed an accumulation of NLC in the outer portions of the epidermis, precisely in the hair follicle. The NLCs distribution in the skin suggests that 17-α-estradiol targeting was improved.

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Section: Studies Of Interaction Of Nanoparticles and Human Skinsupporting

confidence: 92%

Nanostructured Lipid Carriers Loaded with 17-α-Estradiol Accumulate into Hair Follicles

Silva

Jesus

2020

J. Braz. Chem. Soc.

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“…13,14 These are explored for drug delivery through different routes of administration including oral, 15 pulmonary, 16 nasal, parenteral, 17 ocular, 18 brain 19 and dermal-transdermal routes. 20,21 The reports focused on cyclodextrin (CD) which discusses its role in oral cancer therapy, 22 pharmaceutical and biomedical applications of CD-based nanogels 23 and in drug and gene delivery are available. [24][25][26][27] Despite the varied potential of NPs, they possess lacuna related to some physicochemical and pharmaceutical aspects.…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

2020

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Colloidal nanoparticulate technology has been described in the literature as a versatile drug delivery system. But it possesses some inherent lacunae in their formulation. Cyclodextrins (CDs) have been extensively reported for the solubility enhancement of poorly water-soluble drugs. The CDs can cause intervention in aspects related to nanoparticles (NPs) that include improving drug loading in nano-system, improving stability, site-specific/targeted drug delivery, improving solubility profile and absorption of the drug in nanosystem with consequent improvement in bioavailability, with the possibility of controlled release, safety and efficacy. They find application in for simultaneous diagnosis and therapeutics for better treatment procedures. The current communication is focused on the application of CDs to overcome troubles in nanoparticulate formulation and enhancement of their performance. It also envisages the theranostic aspects of CDs.

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“…To enhance the penetration of drugs through the skin but to also allow the loading of lipophilic active agents, nanosized carriers are being used [ 4 ]. Chitosan nanoparticles (CS-NPs) stand out in transdermal formulations [ 5 , 6 , 7 , 8 , 9 ]. CS is a naturally derived polymer, well established as a drug carrier owning biocompatibility, low immunogenicity, biodegradability, mucoadhesivity, in situ gelation, permeation enhancement, and inherent antimicrobial activity [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Curcumin (Cur) is a polyphenol of natural origin isolated from turmeric that is characterized as “GRAS” (generally recognized as safe) by the U.S. Food and Drug Administration [ 6 ]. Cur shows anti-inflammatory, antioxidant, anticancer, and wound healing properties [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…The most recent ones include nanoemulsions [ 21 , 29 ], nanohydrogels [ 22 ], nanoparticles [ 25 , 30 ] with a focus on CS [ 5 ] and nanoparticles in hydrogels [ 31 , 32 ], nanostructured lipid carriers [ 33 ], lipid-based self-nanoemulsifying systems [ 34 ], and ethosomes [ 24 ]. Cur-loaded CS-NPs have superior permeation through Strat-M membranes and mouse skin [ 6 ] and significantly accelerate wound healing rates [ 5 , 8 ]. Recently, to prolong the effectiveness of Cur for transdermal delivery applications, it was loaded in ethosomes that had improved inflammatory effect in comparison with pure Cur [ 18 ], in composite membranes of cellulose with piperine to enhance its skin permeation [ 35 ], and in patches of hydroxymethyl propyl cellulose with acceptable sustained release rates [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Evaluation of Collagen-Based Patches as Curcumin Carriers

Terzopoulou

Michopoulou²,

Palamidi

et al. 2020

Polymers

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Patients with psoriasis are dissatisfied with the standard pharmacological treatments, whether systemic or topical, with many of them showing interest in complementary and alternative medicine. Curcumin (Cur), a natural polyphenol derived from turmeric, has recently gained attention for skin-related diseases because of its proven anti-inflammatory action. However, topical treatment with Cur would be inadequate because of its hydrophobicity, instability, and low bioavailability. In addition, hyperkeratosis and lack of moisture in psoriatic skin result in low penetration that would prevent actives from permeating the stratum corneum. In this work, a polymer-based formulation of Cur for the topical treatment of psoriasis is reported. To improve the physicochemical stability of Cur, it was first encapsulated in chitosan nanoparticles. The Cur-loaded nanoparticles were incorporated in a hydrophilic, biocompatible collagen-based patch. The nanoparticle-containing porous collagen patches were then chemically cross-linked. Morphology, chemical interactions, swelling ratio, enzymatic hydrolysis, and Cur release from the patches were evaluated. All patches showed excellent swelling ratio, up to ~1500%, and after cross-linking, the pore size decreased, and their hydrolysis rates decelerated. The in vitro release of Cur was sustained with an initial burst release, reaching 55% after 24 h. Cur within the scaffolds imparted a proliferation inhibitory effect on psoriatic human keratinocytes in vitro.

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Tracking the transdermal penetration pathways of optimized curcumin-loaded chitosan nanoparticles via confocal laser scanning microscopy

Cited by 104 publications

References 100 publications

Nanostructured Lipid Carriers Loaded with 17-α-Estradiol Accumulate into Hair Follicles

Nanostructured Lipid Carriers Loaded with 17-α-Estradiol Accumulate into Hair Follicles

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Preparation and Evaluation of Collagen-Based Patches as Curcumin Carriers

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