Tract-based spatial statistics analysis of diffusion-tensor imaging data in pediatric- and adult-onset multiple sclerosis

Aliotta, Rachel E.; Cox, Jennifer L.; Donohue, Katelyn; Weinstock‐Guttman, Bianca; Yeh, E. Ann; Polak, Paul; Dwyer, Michael G.; Zivadinov, Robert

doi:10.1002/hbm.22148

Cited by 17 publications

(18 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, white matter microstructural changes including focal tissue damage (lesions) and alterations to normal‐appearing white matter occur in youth with MS and monophasic demyelinating disorders (Amato et al, ; Amato, Krupp, Charvet, Penner, & Till, ; Aubert‐Broche et al, , ; Longoni et al, ). DTI has been used extensively in children and adolescents with acquired demyelinating disorders to demonstrate tissue abnormality in normal‐appearing white matter (Akbar et al, ; Aliotta et al, ; Aung et al, ; Longoni et al, ; Rocca et al, ; Till et al, ; Tillman, Leach, & Pirko, ; Vishwas et al, ; Vishwas, Chitnis, Pienaar, Healy, & Grant, ).…”

Section: Introductionmentioning

confidence: 99%

White matter plasticity and maturation in human cognition

Bells

Lefebvre

Longoni

et al. 2019

Glia

View full text Add to dashboard Cite

White matter plasticity likely plays a critical role in supporting cognitive development. However, few studies have used the imaging methods specific to white matter tissue structure or experimental designs sensitive to change in white matter necessary to elucidate these relations. Here we briefly review novel imaging approaches that provide more specific information regarding white matter microstructure. Furthermore, we highlight recent studies that provide greater clarity regarding the relations between changes in white matter and cognition maturation in both healthy children and adolescents and those with white matter insult. Finally, we examine the hypothesis that white matter is linked to cognitive function via its impact on neural synchronization. We test this hypothesis in a population of children and adolescents with recurrent demyelinating syndromes. Specifically, we evaluate group differences in white matter microstructure within the optic radiation; and neural phase synchrony in visual cortex during a visual task between 25 patients and 28 typically developing age‐matched controls. Children and adolescents with demyelinating syndromes show evidence of myelin and axonal compromise and this compromise predicts reduced phase synchrony during a visual task compared to typically developing controls. We investigate one plausible mechanism at play in this relationship using a computational model of gamma generation in early visual cortical areas. Overall, our findings show a fundamental connection between white matter microstructure and neural synchronization that may be critical for cognitive processing. In the future, longitudinal or interventional studies can build upon our knowledge of these exciting relations between white matter, neural communication, and cognition.

show abstract

Section: Introductionmentioning

confidence: 99%

White matter plasticity and maturation in human cognition

Bells

Lefebvre

Longoni

et al. 2019

Glia

View full text Add to dashboard Cite

show abstract

“…1,69,70 DTI studies show nonlesional widespread tissue destruction of the normal-appearing white matter (NAWM), and show that these changes are already seen early in the disease course. [71][72][73][74] The latter DTI changes in NAWM correlate to some degree with T2 lesion burden [75][76][77] and Wallerian degeneration is discussed to be one of the responsible mechanisms. 76 One of the predominant affected regions in children with confirmed MS is the corpus callosum comprising major pathways (►Fig.…”

Section: Monitoring the Impact Of Ms On The Pediatric Brainmentioning

confidence: 98%

Imaging Pediatric Multiple Sclerosis—Challenges and Recent Advances

et al. 2018

View full text Add to dashboard Cite

Pediatric onset multiple sclerosis (POMS) is a rare disease with an incidence of 0.07 to 2.9/100'000 children per year. It follows a relapsing-remitting disease course and is characterized by rapid accrual of inflammatory lesions, high relapse frequency, and early cognitive impairment. Magnetic resonance imaging (MRI) plays a pivotal role in the diagnosis of POMS, and in the exclusion of other disorders mimicking POMS. Furthermore, MRI aids in disease monitoring, and in the evaluation of therapeutic efficacy in both clinical practice and clinical trials. Volumetric MRI studies, diffusion tensor imaging, resting-state, and task-based functional MRI provide deeper insight into the impact of POMS on maturing neural networks. This review article aims to highlight the importance of MRI in the care of POMS patients and to provide an overview on the different MRI techniques used in the management of POMS.

show abstract

“…Patients with adult-onset multiple sclerosis, who were matched for disease duration to patients with pediatric-onset multiple sclerosis, showed a significant increase in FA in the posterior cortical white matter tracts (Aliotta et al, 2012), suggesting that a younger age at disease onset may be more responsible for microstructural white matter abnormalities than older age or longer disease duration. Patients with adult-onset multiple sclerosis, who were matched for disease duration to patients with pediatric-onset multiple sclerosis, showed a significant increase in FA in the posterior cortical white matter tracts (Aliotta et al, 2012), suggesting that a younger age at disease onset may be more responsible for microstructural white matter abnormalities than older age or longer disease duration.…”

Section: Assessment Of Local Diffusion Parameters In Multiple Sclerosismentioning

confidence: 99%