Trading Lives or Changing Human Nature: The Strange Dilemma of Embryo-Based Regenerative Medicine

McGee, Glenn

doi:10.1007/978-1-4020-8967-1_7

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2022

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“…[28] This can be avoided by using ESCs. However, ESCs raise ethical concerns [29][30][31] and are, in contrast to iPSCs, neither autologous nor unlimited in supply. The methods for generating RPE cells from iPSCs [32,33] and ESCs [34,35] have been described in detail.…”

Section: Introductionmentioning

confidence: 99%

Retinal Pigment Epithelium Transplantation: Past, Present, and Future

Khan

Utheim

Eidet

2022

JOVR

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Retinal pigment epithelium (RPE) is a monolayer of cells situated between photoreceptors and the underlying choroid. It is essential for normal retinal function. Damaged RPE is associated with diseases such as age-related macular degeneration, Stargardt’s macular dystrophy, and retinitis pigmentosa. RPE cells can easily be visualized in vivo, sustainable in vitro, and differentiated from stem cells with a relatively straightforward protocol. Due to these properties and the clinical significance of this epithelium in various retinal diseases, RPE transplantation as a treatment modality has gained considerable interest in the last decade. This paper presents the main techniques for RPE transplantation and discusses recent clinically relevant publications.

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