Traditional Chinese medicine in thyroid-associated orbitopathy

Hai, Yuanping; Lee, A. C. H.; Chen, Kunni; Kahaly, George J.

doi:10.1007/s40618-023-02024-4

Cited by 4 publications

(3 citation statements)

References 102 publications

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“…Furthermore, it would be optimal to conduct serum selenium testing prior to commencing supplementation in order to prevent potential overdose ( 33 ). Additionally, extensive research has been conducted on the efficacy of various Chinese medicines in ameliorating symptoms and signs associated with GD, as well as expediting the treatment process ( 34 , 35 ). Such as: Diosgenin (Dio) had control effects on goiter and hyperthyroidism in GD mice through affecting thyroid cell proliferation, but not the expression of TRAB ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

Puerarin inhibits inflammation and oxidative stress in female BALB/c mouse models of Graves’ disease

Ye,

Wu,

Chen

et al. 2024

Transl Pediatr

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Background Graves’ disease (GD) is an autoimmune thyroid disorder. Our previous study has demonstrated a significant decrease in flavone levels among children with GD compared to the control group. Puerarin, a well-known flavonoid with anti-inflammatory and antioxidant properties. We wanted to investigate its potential impact on GD pathogenesis, aiming to determine whether increasing puerarin intake could prevent or delay the onset of GD. Methods Adenovirus with TSHR-289 subunit was used to establish a GD mice model, and mice were intragastrically administered with puerarin or sterilized water daily. Thyroid function and inflammatory cytokine levels were quantified using ELISA, lymphocyte subsets were analyzed via flow cytometry, oxidative stress (OS) markers were measured with a microplate reader, and the expression of pertinent signaling pathway proteins were assessed by Western blot. Results The results demonstrated that puerarin treatment significantly decreased thyroxin levels and alleviated thyroid pathological changes in GD mice. Furthermore, the immune imbalance of GD mice was improved, as evidenced by reduced inflammatory indexes, elevated antioxidant levels, and decreased malondialdehyde (MDA) levels compared to untreated GD mice. Puerarin-treated GD mice exhibited significantly lower expressions of heat shock protein (HSP): HSP70, HSP90, phosphorylated extracellular regulated kinases (p-ERK) and phosphorylated protein kinase B (p-AKT) than untreated GD mice. Moreover, low dosage puerarin (400 mg/kg) was associated with a better protective effect than high dosage (1,200 mg/kg). Conclusions Puerarin may have the potential to mitigate GD by inhibiting inflammatory and OS, through downregulating the expression of HSP70 and HSP90 and suppressing the activation of the PI3K/AKT/ERK signaling pathway. Furthermore, a lower dose exhibited superior protective effects compared to a higher dose.

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Section: Discussionmentioning

confidence: 99%

Puerarin inhibits inflammation and oxidative stress in female BALB/c mouse models of Graves’ disease

Ye,

Wu,

Chen

et al. 2024

Transl Pediatr

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“…There is a large infiltration of inflammatory cells, such as T cells, B cells, and macrophages, in the orbital tissues of TAO patients. These inflammatory cells further exacerbate orbital tissue damage by secreting various inflammatory factors, such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) ( 22 ). In addition, fibrosis is the final pathological change in the pathologic process of TAO.…”

Section: Oxidative Stress In Taomentioning

confidence: 99%

Thyroid-associated ophthalmopathy: the role of oxidative stress

Ma,

Li,

et al. 2024

Front. Endocrinol.

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Thyroid-associated ophthalmopathy (TAO) is an autoimmune condition affecting the eyes, characterized by proptosis, extraocular muscle involvement, and in severe cases, vision impairment including diplopia, optic neuropathy, and potential blindness. The exact etiology of TAO remains elusive; however, increased oxidative stress and decreased antioxidant capacity are pivotal in its pathogenesis. Elevated oxidative stress not only directly damages orbital tissues but also influences thyroid function and autoimmune responses, exacerbating tissue destruction. This review explores the role of oxidative stress in TAO, elucidates its mechanisms, and evaluates the efficacy and limitations of antioxidant therapies in managing TAO. The findings aim to enhance understanding of oxidative stress mechanisms in TAO and propose potential antioxidant strategies for future therapeutic development.

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“…Sustainable and accessible healthcare, local knowledge of traditional medicine and food ingredients can provide cost-effective and accessible healthcare options, particularly for remote and marginalized communities. Hai et al (2023) otherwise very traditional medicine and food ingredients Hardened because it is open to the public in terms of price and availability. Understanding the Anak Dalam Tribe's traditional healthcare practices can help identify sustainable resources, promote self-sufficiency, and reduce dependence on expensive pharmaceuticals.…”

Section: A Introductionmentioning

confidence: 99%

Exploration of Local Knowledge Traditional Medicine and Food Ingredients of The Anak Dalam Tribe, Duano, Kerinci As a Source of Public Health Knowledge

Mustakim,

Nirmala,

Anattri

et al. 2023

PIJED

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The purpose of this study was to explore local knowledge and traditional food ingredients for the Anak Dalam, Duano and Kerinci people, especially those related to traditional medicine and food ingredients for each Jambi tribes. The Anak Dalam, Duano and Kerinci tribes have a rich cultural heritage, with local knowledge on spices and ingredients passed down from generation to generation. This study examines local wisdom as a source of public health. This type of qualitative research with an ethnographic approach to data collection was carried out through observation, interviews, focused discussions (FGD) and documentation with the Anak Dalam, Duano and Kerinci ethnic community. As a result, we found that the Anak Dalam tribe has Basale treatment, Duano has the Kelung ritual, and Kerinci has a lot of knowledge about local medicines and different foods, one of which is Betemas/Tasapa. In addition, the traditional diet of the Suku Anak Dalam, Duano and Kerinci tribe emphasizes the use of locally available ingredients for their nutritional and medicinal properties. This study highlights the importance of local knowledge in public health information resources. In addition, traditional food ingredients provide information about sustainable diets and potential sources of new compounds, this research contributed in finding the novelty of etnosains and etnofood Jambi tribes. This research concludes that raising awareness through the documentation of traditional knowledge Jambi's indigenous people is important for the preservation and regeneration of cultural heritage. As result, Studying the local knowledge of traditional medicine and ingredients of the Anak Dalam, Duano, Kerinci tribes are valuable insights for public health.

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Traditional Chinese medicine in thyroid-associated orbitopathy

Cited by 4 publications

References 102 publications

Puerarin inhibits inflammation and oxidative stress in female BALB/c mouse models of Graves’ disease

Puerarin inhibits inflammation and oxidative stress in female BALB/c mouse models of Graves’ disease

Thyroid-associated ophthalmopathy: the role of oxidative stress

Exploration of Local Knowledge Traditional Medicine and Food Ingredients of The Anak Dalam Tribe, Duano, Kerinci As a Source of Public Health Knowledge

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