Traditional Knowledge to Contemporary Medication in the Treatment of Infectious Disease Dengue: A Review

Dhiman, Mamta; Sharma, Lokesh; Dadhich, Abhishek; Dhawan, Poonam; Sharma, Madan Mohan

doi:10.3389/fphar.2022.750494

Cited by 11 publications

(3 citation statements)

References 196 publications

(161 reference statements)

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“…Dengue is a complex disease, which has made the discovery of effective therapies difficult. Studies support the view that herbal medication could be useful for treating DENV infections, which could reduce the risk of severe dengue if started soon after exposure to the virus [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Essential Oils from Colombian Plants: Antiviral Potential against Dengue Virus Based on Chemical Composition, In Vitro and In Silico Analyses

et al. 2022

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Currently, there are no therapies to prevent severe dengue disease. Essential oils (EOs) can serve as primary sources for research and the discovery of phytomedicines for alternative therapy. Fourteen EOs samples were obtained by distillation from six plants used in Colombian folk medicine. GC/MS analysis identified 125 terpenes. Cytopathic effect (CPE) reduction assays revealed differences in antiviral activity. EOs of Lippia alba, citral chemotype and carvone-rich fraction; Lippia origanoides, phellandrene chemotype; and Turnera diffusa, exhibited strong antiviral activity (IC50: 29 to 82 µg/mL; SI: 5.5 to 14.3). EOs of Piper aduncum, Ocimum basilicum, and L. origanoides, carvacrol, and thymol chemotypes, exhibited weak antiviral activity (32 to 53% DENV-CPE reduction at 100 µg/mL; SI > 5.0). Cluster and one-way ANOVA analyses suggest that the strong antiviral activity of EOs could be attributed to increased amounts of non-phenolic oxygenated monoterpenes and sesquiterpene hydrocarbons. Docking analyses (AutoDock Vina) predicted binding affinity between the DENV-2 E protein and terpenes: twenty sesquiterpene hydrocarbons (−8.73 to −6.91 kcal/mol), eight oxygenated monoterpenes (−7.52 to −6.98 kcal/mol), and seven monoterpene hydrocarbons (−7.60 to −6.99 kcal/mol). This study reports for the first time differences in the antiviral activity of EOs against DENV, corresponding to their composition of monoterpenes and sesquiterpenes.

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Section: Introductionmentioning

confidence: 99%

Essential Oils from Colombian Plants: Antiviral Potential against Dengue Virus Based on Chemical Composition, In Vitro and In Silico Analyses

et al. 2022

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“…However, further research is required to assess its effectiveness and safety in humans (Do and Reau 2020). Moreover, a wide range of naturally occurring substances, including mangiferin-punicalagin, alphamangostin, geraniin, curcumin-flavonoids, and quercetin derived from various plant sources have shown activity against DENV (Clain et al 2018;Fitmawati et al 2021;Kowalczyk et al 2021;Santhi et al 2021;Patil et al 2021;Dhiman et al 2022) .…”

Section: Direct Anti-viral Agents (Daa)mentioning

confidence: 99%

Etiology, Treatment and Complications of Dengue Fever: A systematic Analysis

2023

IJAB

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Dengue fever, a viral illness transmitted by mosquitoes, presents a major health concern worldwide, especially in warm and humid areas. This comprehensive examination delves into the important aspects of Dengue Fever, such as its causes, methods of treatment, and potential negative effects. The Dengue virus, which has four different serotypes, is primarily transmitted through the bite of Aedes mosquitoes that are infected. Comprehensive knowledge of the numerous underlying causes is essential for creating successful measures to prevent and manage the issue. The primary approach to treating Dengue Fever is providing support by relieving symptoms and preventing further complications. Managing pain and fever can be achieved with analgesics such as acetaminophen, and it is crucial to carefully monitor fluid intake to avoid dehydration. In serious instances, hospitalization, blood transfusions, and careful monitoring may be required to reduce the likelihood of developing complications like Dengue Hemorrhagic Fever and Dengue Shock Syndrome. These serious symptoms include bleeding, fluid escaping from blood vessels, and, occasionally, damage to organs, underscoring the necessity of identifying and addressing the problem early. Preventive measures include controlling the mosquito population by getting rid of their breeding sites, using insecticides, and encouraging individuals to use personal protective measures. Furthermore, vaccination initiatives have become a hopeful solution in regions with high disease prevalence. This thorough analysis offers a complete picture of Dengue Fever, highlighting the importance of comprehensive approaches that cover understanding the cause, treatment plans, and strong prevention methods to reduce the impact of this widespread and potentially serious viral illness.

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“…DENV is believed to have emerged from a sylvatic cycle with the primary hosts being non-human primates to a human epidemic/endemic cycle some 1000–1500 years ago [ 3 ]. Since its emergence into the human population treatment for DENV will primarily have been through the use of natural medicines which were believed to have anti-inflammatory or antipyretic activity [ 4 ], and thus it is possible that some plants used traditionally to treat febrile diseases contain bioactive constituents with antiviral activity.…”

Section: Introductionmentioning

confidence: 99%

Oroxylin A shows limited antiviral activity towards dengue virus

et al. 2022

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Objective The mosquito transmitted dengue virus (DENV) the causative agent of dengue fever (DF) remains a significant public health burden in many countries. Thailand, along with many countries in Asia and elsewhere, has a long history of using traditional medicines to combat febrile diseases such as DF. Screening bioactive compounds from traditional medicines reported to have antipyretic or anti-inflammatory activity may lead to the development of potent antivirals. In this study oroxylin A (OA), a flavonoid derivative found in Oroxylum indicum (commonly called the Indian trumpet flower or tree of Damocles), was screened for antiviral activity towards DENV. Results Cytotoxicity analysis in BHK-21 cells showed a 50% cytotoxic concentration (CC50) of 534.17 µM. The compound showed no direct virucidal activity towards DENV, and pre-treatment of cells had no effect on virus production. A deficit was seen in virus production when cells were post-infection treated with oroxylin A. Under conditions of post-infection treatment, the EC50 value was 201.1 µM, giving a selectivity index (SI) value of 2.66. Accumulation of DENV E protein inside the cell was seen under conditions of post-infection treatment, suggesting that oroxylin A may exert some effects at the virus assembly/egress stages of the replication cycle.

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Traditional Knowledge to Contemporary Medication in the Treatment of Infectious Disease Dengue: A Review

Cited by 11 publications

References 196 publications

Essential Oils from Colombian Plants: Antiviral Potential against Dengue Virus Based on Chemical Composition, In Vitro and In Silico Analyses

Essential Oils from Colombian Plants: Antiviral Potential against Dengue Virus Based on Chemical Composition, In Vitro and In Silico Analyses

Etiology, Treatment and Complications of Dengue Fever: A systematic Analysis

Oroxylin A shows limited antiviral activity towards dengue virus

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