Traditional plant-based remedies to control gastrointestinal disorders in livestock in the regions of Kamina and Kaniama (Katanga province, Democratic Republic of Congo)

Traditional plants used for the treatment of gynaecological disorders in Vedaranyam taluk, South India - An ethnomedicinal survey

“… Not reported 3. Acacia farnesiana L. (Mimosaceae) PHC-1340 Kasthurivel ( ) Tree Bark 94 Leucorrhoea: White discharge from the reproductive organ (IR:87) Menorrhagia : Excessive level of blood flow with long days (IR:47) 134 0.783 1.425 1.116 Powder Mixed with Hot water then taken orally 34 4. Achyranthes aspera L. (Amaranthaceae) PHC-1354 Nayuruvi ( ) Herb Root Leaves 92 Easy delivery : Less pain delivery during delivery time (IR:92) Amenorrhoe a: Absence of menstrual period (IR:91) Dysmenorrhoea: Painful menstruation (IR:63) 246 0.766 2.673 2.050 Powder Decoction Decoction Mixed with water, then taken orally before delivery.…”

“…(Acanthaceae) PHC-1360 Aadathodai ( ) Shrub Root 103 Easy delivery: Less pain delivery during childbirth (IR:81) 81 0.858 0.786 0.675 Decoction Dried leaves boiled with water, then filter the decoction and taken orally 23 7. Annona squamosa L. (Annonaceae) PHC-1353 Seettha ( ) Tree Root 64 Abortion: Avoid unnecessary pregnancy without any effects (IR:36) 36 0.533 0.562 0.300 Powder Mixed with water, then taken orally during pregnancy 34 8. Aristolochia indica L. (Aristolochiaceae) PHC-1366 Eeswaramuli ( ) Climber Root Root 89 Menstrual disorders: Irregular menstrual periods (IR:83) Over bleeding: Excessive flow of blood during menstrual periods (IR:49) 132 0.741 1.483 1.100 Powder Decoction Mixed with ordinary water, then taken orally in the daily early morning 5–7 days Dried root boiled with water, then filter the decoction and taken orally 34 9.…”

Screening of a small, well-curated natural product-based library identifies two rotenoids with potent nematocidal activity against Haemonchus contortus

“…For instance, deguelin has been reported to affect some cancers (of lung, stomach and prostate) Udeani et al, 1997;Lee et al, 2005;Aruldmpalam et al, 2011;Boreddy and Srivastava, 2013;Farmer et al, 2013;Shang et al, 2014), and has anti-inflammatory, anti-angiogenic and apoptotic effects (Lee, 2004;Paulus et al, 2012). In addition, rotenoids extracted from plants such as Derris elliptica (Tuba plant), D. involuta (Jewel vine), Lonchocarpus utilis (Cub) or L. urucu (Barbasco) have been used as natural acaricides or insecticides (e.g., Ashack et al, 1980;Embeya et al, 2014). As rotenone is lethal to fishes but not to mammals to the same extent (Isman, 2006), there would be considerable concerns about its use as a parasiticide.…”

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

“…Adult worms within the stomach then mate and the female will produce eggs, which are excreted by the host in feces; individual f i r s t -s t a g el a r v a e( L 1 s )d e v e l o pi n s i d ee g g s ,t h e nh a t c h (usually within 1 d) and develop through to the secondstage larvae and L3s in approximately 1 wk.Deguelin and other rotenoids-for example, rotenone and tephrosin-of the flavonoid group are derived from plants of the family Leguminosae (e.g., Lonchocarpus, Derris, Cassia,andTephrosia)(6-10). For example, resins that contain rotenoids extracted from the roots of Lonchocarpus utiliz (cubé), Lonchocarpus urucu (barbasco), Derris elliptica (tuba plant), or Derris involuta (jewel vine) have been used in many countries as natural insecticides, acaricides, and/or piscicides (11,12). Deguelin also has therapeutic effects against a range of cancers-for example, in lung, stomach, and prostate-being able to inhibit tumor progression (13)(14)(15)(16)(17)(18)(19) with potent apoptotic and antiangiogenic activities in vitro (20).Deguelinisalsousedtoimprovethesuccessoforgan transplantation by reducing associated inflammation (21).A l t h o u g ht h e r ew e r es o m ee a r l yc o n c e r n sa b o u tt h e safety of using deguelin in mammals as a result of the lethal effect of the analog rotenone on fishes and arthropods (13,14), and because of Parkinson'sd i s e a s e -like symptoms in mice after chronic administration of deguelin (6 mg/kg/d) (22), no appreciable levels of toxicity or adverse effects of deguelin at therapeutic doses (2-5mg/kg) have been recorded in rodents (mice and rats) (15,17,23,24).…”

“…Deguelin and other rotenoids-for example, rotenone and tephrosin-of the flavonoid group are derived from plants of the family Leguminosae (e.g., Lonchocarpus, Derris, Cassia,andTephrosia)(6-10). For example, resins that contain rotenoids extracted from the roots of Lonchocarpus utiliz (cubé), Lonchocarpus urucu (barbasco), Derris elliptica (tuba plant), or Derris involuta (jewel vine) have been used in many countries as natural insecticides, acaricides, and/or piscicides (11,12). Deguelin also has therapeutic effects against a range of cancers-for example, in lung, stomach, and prostate-being able to inhibit tumor progression (13)(14)(15)(16)(17)(18)(19) with potent apoptotic and antiangiogenic activities in vitro (20).Deguelinisalsousedtoimprovethesuccessoforgan transplantation by reducing associated inflammation (21).…”