Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life

Gruzieva, Olena; Bellander, Tom; Eneroth, Kristina; Kull, Inger; Melén, Erik; Nordling, Emma; Hage, Marianne van; Wickman, Magnus; Москаленко, В. Ф.; Hulchiy, Olesya; Pershagen, Göran

doi:10.1016/j.jaci.2011.11.001

Cited by 129 publications

(101 citation statements)

References 40 publications

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“…Several other environmental factors may increase the immune potential of allergens [59]; in particular, evidence for a role of pollution in the rise of asthma and allergy is accumulating [71]. Diesel exhaust particles (DEPs) are of particular interest as they are able to reach distal airways due to their small size (100 nm) and to enhance local IgE synthesis [72].…”

Section: Air Pollutionmentioning

confidence: 99%

Asthma phenotypes and IgE responses

et al. 2015

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The discovery of IgE represented a major breakthrough in allergy and asthma research, whereas the clinical interest given to IgE in asthma has been blurred until the arrival of anti-IgE biotherapy. Novel facets of the complex link between IgE and asthma have been highlighted by the effect of this treatment and by basic research. In parallel, asthma phenotyping recently evolved to the concept of endotypes, relying on identified/suspected pathobiological mechanisms to phenotype patients, but has not yet clearly positioned IgE among biomarkers of asthma.In this review, we first summarise recent knowledge about the regulation of IgE production and its main receptor, FcεRI. In addition to allergens acting as classical IgE inducers, viral infections as well as air pollution may trigger the IgE pathway, notably resetting the threshold of IgE sensitivity by regulating FcεRI expression. We then analyse the place of IgE in different asthma endo/phenotypes and discuss the potential interest of IgE among biomarkers in asthma. @ERSpublications We summarise regulation of IgE production, and discuss IgE in different asthma endo/ phenotypes and among biomarkers

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Section: Air Pollutionmentioning

confidence: 99%

Asthma phenotypes and IgE responses

et al. 2015

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“…Several studies showed a positive association between exposure to air pollution during infancy and sensitization to inhalant allergens (145)(146)(147). Although the mechanism underlying this association is not fully understood, some evidence suggests that ultrafine carbon black particles can directly induce maturation of dendritic cells in vitro (148), thereby facilitating sensitization to inhalant allergens.…”

Section: Pollutionmentioning

confidence: 99%

Allergy in severe asthma

Giacco

Bakırtaş

Bel

et al. 2016

Allergy

116

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It is well recognized that atopic sensitization is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term 'Severe Asthma' encompasses a highly heterogeneous group of patients who require treatment on steps 4-5 of GINA guidelines to prevent their asthma from becoming 'uncontrolled', or whose disease remains 'uncontrolled' despite this therapy. Epidemiological studies on emergency room visits and hospital admissions for asthma suggest the important role of allergy in asthma exacerbations. In addition, allergic asthma in childhood is often associated with severe asthma in adulthood. A strong association exists between asthma exacerbations and respiratory viral infections, and interaction between viruses and allergy further increases the risk of asthma exacerbations. Furthermore, fungal allergy has been shown to play an important role in severe asthma. Other contributing factors include smoking, pollution and work-related exposures. The 'Allergy and Asthma Severity' EAACI Task Force examined the current evidence and produced this position document on the role of allergy in severe asthma.

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“…Other studies have examined the effects of multiple pollutants in the proximity of roads for respiratory health and allergic disease outcomes (Brunekreef et al, 1997;van Vliet et al, 1997;Nicolai et al, 2003;Kim J et al, 2004;Gauderman et al, 2005;Morgenstern et al, 2008;Rosenlund et al, 2009a;McConnell et al, 2010;Gehring et al, 2010;Clark et al, 2010;Gruzieva et al, 2012Gruzieva et al, , 2013Schultz et al, 2012;Willers et al, 2013), birth weight (Brauer et al, 2008), pre-eclampsia and preterm birth (Wu et al, 2011), fatal myocardial infarction (Rosenlund et al, 2006(Rosenlund et al, , 2009b, lung cancer (Nyberg et al, 2000) and mortality (Beelen et al, 2008a). However in their analyses these investigators used either a proximity to road measure or a specific pollutant(s), but never the effects of (multiple) pollutants within proximity to roads.…”

Section: Rationalementioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life

Cited by 129 publications

References 40 publications

Asthma phenotypes and IgE responses

Asthma phenotypes and IgE responses

Allergy in severe asthma

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

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