Trait creativity, personality, and physical activity: a structural equation model

Li, Cuiping; Liu, Xiaohong; Wang, Xinjuan; He, Lianping

doi:10.21037/apm-22-1310

Cited by 11 publications

(7 citation statements)

References 40 publications

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“…This study did not examine the interaction of diet (e. g., Vitamin D intake) and genetics on PC. Physical activity might play a protective role against PC development [34,35].…”

Section: Discussionmentioning

confidence: 99%

Mir-629 Repressed LATS2 Expression and Promoted the Proliferation of Prostate Cancer Cells

Zeng

Cao

2023

Horm Metab Res

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MicroRNAs (miRNAs) have been discovered to play critical role in regulating prostate cancer (PC) progression. The function role of miR-629 in tumor progression of PC has not been studied. Here, we found that miR-629 was markedly up-regulated in PC determined using the cancer genome atlas (TCGA) dataset, clinical tissues, and cell lines. Functional analysis (MTT assays, colony formation assays, soft agar growth assay and BrdU incorporation assay) indicated that overexpression of miR-629 drastically promoted, while miR-629-in significantly suppressed cell proliferation. LATS2 was predicted as a direct target of miR-629, and was confirmed by western blot and dual luciferase assay. Through down-regulation of large tumor suppressor 2(LATS2) by overexpression of miR-629, decreased the p21 mRNA and protein, while enhance the Cyclin D3 mRNA and protein, suggesting promoting cell proliferation process. Additionally, knockdown of LATS2 reversed the inhibitory effect by miR-629-in in PC. Our study indicated that miR-629 might serve as new promising target for PC treatment.

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“…This study did not examine the interaction of diet (e. g., Vitamin D intake) and genetics on PC. Physical activity might play a protective role against PC development [34,35].…”

Section: Discussionmentioning

confidence: 99%

Mir-629 Repressed LATS2 Expression and Promoted the Proliferation of Prostate Cancer Cells

Zeng

Cao

2023

Horm Metab Res

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“…This study did not examine the interaction of diet (e.g., vitamin D intake) and genetics on PC. Physical activity might play a protective role against PC development [ 23 , 24 ]. The role of interaction between physical activity and gene on PC should be explored.…”

Section: Discussionmentioning

confidence: 99%

Association of Androgen-Receptor Gene Mutations with the Copy Number of Androgen-Receptor Silk Protein A Complex and Glutathione-S-Transferases T1 and M1 in Prostate Cancer Patients

Zhang

Meng

et al. 2023

Genetics Research

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Objective. The purpose of our work was to explore the association of mutations in the androgen receptor gene and copy numbers of the androgen-receptor silk protein A complex with glutathione-S-transferases T1 and M1 in prostate cancer patients. Materials and Methods. Eighty-five patients with PC and 85 healthy controls were included in the study. Fasting peripheral venous blood was collected, whole blood genomic DNA was extracted, and AR gene-receptor genotype was detected by a high-resolution melting curve analysis detection technology. Expression levels of androgen receptor (AR) and filamin protein A (FlnA) were detected by Western blotting. RT-PCR was used to detect the copy number of T1 and M1 glutathione-S-transferases. Results. The wild-type androgen receptor gene rs5918762 is of TT type. The frequencies of CC and TC genes in the prostate cancer group were significantly higher than those in the normal control group P < 0.05 . Compared with TT-type PC patients, PC patients with TC-type and CC-type had higher expression levels of sex hormone receptor silk protein A complex and higher copy numbers of GSTT1 and GSTM1 P < 0.05 . Androgen-receptor gene mutation (T ⟶ C) was significantly positively correlated with the expression level of androgen-receptor silk protein A complex and the copy number of GSTT1 and GSTM1. Conclusion. Androgen-receptor gene polymorphisms were significantly associated with expression levels of androgen receptor complex A and silk proteins, and copy numbers of T1 and M1 glutathione-S-transferases. A combination of four factors can be used to identify prostate cancer susceptibility and disease progression.

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“…Physical activity activates the SIRT1 pathway, 62 which has also been linked to creativity. 63 Physical activity can also indirectly regulate the activity and expression of GPX4. As mentioned above, GPX4 signalling pathway as a potential therapeutic target for inhibiting ferroptosis.…”

Section: Regulating Gpx4 Pathway In Ferroptosismentioning

confidence: 99%

“…In additional, sphingosine 1‐phosphate (S1P) alleviates radiation‐induced ferroptosis in ovarian granulosa cells by upregulating GPX4. Physical activity activates the SIRT1 pathway, 62 which has also been linked to creativity 63 . Physical activity can also indirectly regulate the activity and expression of GPX4.…”

Section: Potential Strategies To Improve Ferroptosismentioning

confidence: 99%

Narrative review of ferroptosis in obesity

Zhou

2023

J Cellular Molecular Medi

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Obesity is widely recognized as a major global health problem caused by a chronic energy imbalance resulting from a combination of excess caloric intake and insufficient energy expenditure. Excessive energy intake and physical inactivity are traditional risk factors for obesity. Obesity is a risk factor for many diseases, including hypertension, diabetes and tumours. Recent studies have found a strong link between ferroptosis and obesity. Ferroptosis is an iron‐dependent regulated cell death caused by iron overload and reactive oxygen species‐dependent excessive accumulation of lipid peroxidation. Ferroptosis is involved in many biological processes, such as amino acid metabolism, iron metabolism and lipid metabolism. Some potential strategies to reduce the adverse effects of ferroptosis on obesity are suggested and future research priorities are highlighted.

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Trait creativity, personality, and physical activity: a structural equation model

Cited by 11 publications

References 40 publications

Mir-629 Repressed LATS2 Expression and Promoted the Proliferation of Prostate Cancer Cells

Mir-629 Repressed LATS2 Expression and Promoted the Proliferation of Prostate Cancer Cells

Association of Androgen-Receptor Gene Mutations with the Copy Number of Androgen-Receptor Silk Protein A Complex and Glutathione-S-Transferases T1 and M1 in Prostate Cancer Patients

Narrative review of ferroptosis in obesity

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