Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA: A Prospective Randomized Controlled Trial

Abstract

Background TKA may be associated with considerable blood loss, and transfusion carries substantial risk of immunologic reaction and disease transmission. Blood transfusion also involves additional cost, therefore a reduction in its use is important. Several methods reportedly reduce postoperative blood loss and avoid homologous blood transfusion with traditional TKA approaches, but it is unclear these reductions apply to a minimally invasive technique. Questions/purposes We asked whether tranexamic acid administration could reduce blood loss and blood transfusion requirements after TKA.

Role of intravenous tranexamic acid for the reduction of blood loss in total knee arthroplasty

“…The above stated results are comparable with studies by charoencholvanich et al [17] , Gautam et al [18] and Lee et al [19] . These authors used similar dose regimen protocols as was used in this study.…”

Tranexamic Acid Use in the Total Hip and Total Knee Arthroplasty Population at an Academic Medical Center: a Retrospective Review of Postoperative Outcomes

“…Nevertheless, a study that reviewed TKA and THA patients for six weeks, found that over 90% of all lifethreatening complications occurred within 4 days after surgery [5] . Multiple studies, including randomized controlled trials [6][7][8][9] and meta-analyses [10][11][12][13][14] have found the same promising results on the effectiveness of TXA. In accordance with our research, multiple other studies have been underpowered to detect a difference in VTE rates.…”

Effect of intravenous tranexamic acid on blood loss and blood transfusion in total knee replacement: a prospective, randomized study in Indian population

“…In our study, similar to the studies in the literature. [31][32][33][34][35] It was found that the mean amount drain output & blood loss were 293 ml & 368 ml respectively in TXA Group however 20% of the patients were given PRBC transfusion. In Control Group mean amount of drain output & total blood loss calculated were 446 & 946 respectively, 56% patients required PRBC transfusion.…”