trans-Golgi network-bound cargo traffic

Makaraci, Pelin; Kim, Dong Kyu

doi:10.1016/j.ejcb.2018.01.003

Cited by 18 publications

(15 citation statements)

References 235 publications

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“…Polar or charged biomolecules that cannot pass through the hydrophobic plasma membrane are internalized by a form of active transport which is called endocytosis. In this process, the cell engulfs the materials inside the extracellular fluid by invagination of CM and buds off inside the cell, forming a membrane-bounded vesicle called an endosome [ 37 ]. Endocytosis can be basically classified into two major categories: phagocytosis and pinocytosis.…”

Section: Cellular Uptake Pathways Of Npsmentioning

confidence: 99%

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

2018

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Nanoparticle science is rapidly changing the landscape of various scientific fields and defining new technological platforms. This is perhaps even more evident in the field of nanomedicine whereby nanoparticles have been used as a tool for the treatment and diagnosis of many diseases. However, despite the tremendous benefit conferred, common pitfalls of this technology is its potential short and long-term effects on the human body. To understand these issues, many scientific studies have been carried out. This review attempts to shed light on some of these studies and its outcomes. The topics that were examined in this review include the different possible uptake pathways of nanoparticles and intracellular trafficking routes. Additionally, the effect of physicochemical properties of nanoparticle such as size, shape, charge and surface chemistry in determining the mechanism of uptake and biological function of nanoparticles are also addressed.

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Section: Cellular Uptake Pathways Of Npsmentioning

confidence: 99%

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

2018

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“…Toxins (such as shiga, ricin, or cholera) and many receptor tyrosine kinases are subject to retrotranslocation from the early endosome in clathrin-coated endosomes, while transmembrane receptors such as wntless, β-secretase (BACE1), and TGN38 interact with the retromer complex from the early endosome [6][7][8][9][10][11] . Trafficking constituents such as mannose 6 phosphate receptor and Vsp10 are directed from late endosomes via the retromer complex [12][13][14] . CME occurs when clathrin triskelions form a bilayered coat of polyhedral lattices surrounding an inner coat of clathrin adaptors.…”

Section: Internalizationmentioning

confidence: 99%

Wrong place at the wrong time: how retrograde trafficking drives cancer metastasis through receptor mislocalization

Maisel¹,

Schroeder²

2019

JCMT

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Retrograde trafficking is a well-regulated, multi-component pathway that can result in endosomal trafficking to the trans-Golgi network, the perinuclear space, or the nucleus. Either clathrin or the retromer complex can travel with proteins endocytosed from the plasma membrane, guided by Rabs (including 5, 6, 7, 9, 22A), interacting with a host of sorting nexin proteins, and fusing with Golgi-specific anchors to allow transport of activated receptor tyrosine kinases to a potential end within the nucleus. Amplification in these constituents is common in cancer, leading to increased retrotranslocation and a reduction in degradation of receptor tyrosine kinases, an event highly associated with cancer metastasis. Here, we review the role of retrograde trafficking in altering transmembrane receptor localization and activity and the relationship to metastasis, focusing on all four members of the ErbB family, with comparison to other receptor tyrosine kinases including the insulin receptor and fibroblast growth factor receptor, as well as other transmembrane proteins dysregulated in metastasis. By examining how these receptors are being alternatively trafficked and the cancer-associated events resulting from this process, we hope to identify novel therapeutic targets.

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“…Golgi stacks are polarized, that is newly synthesized secretory proteins from the endoplasmic reticulum (ER) enter cis and exit trans. The trans-Golgi network (TGN) is located at the trans-most side of the Golgi stacks and is considered as a hub, where exocytic and endocytic pathways meet and act as a sorting center (Hierro et al, 2015;Makaraci and Kim, 2018). Although only reported in plants, the TGN can be divided into two types, Golgi-associated TGN (GA-TGN) and Golgi-independent TGN (GI-TGN, hereafter referred to as free-TGN) (Kang et al, 2011;Uemura et al, 2014;Viotti et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Recycling endosomes attach to the trans-side of Golgi stacks in Drosophila and mammalian cells

Fujii

Kurokawa

Inaba

et al. 2020

Journal of Cell Science

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Historically, the trans-Golgi network (TGN) has been recognized as a sorting center of newly synthesized proteins, whereas the recycling endosome (RE) is a compartment where endocytosed materials transit before being recycled to the plasma membrane. However, recent findings revealed that both the TGN and RE connect endocytosis and exocytosis and, thus, are functionally overlapping. Here we report, in both Drosophila and microtubule-disrupted HeLa cells, that REs are interconvertible between two distinct states, namely Golgiassociated REs and free REs. Detachment and reattachment of REs and Golgi stacks are often observed, and newly synthesized glycosylphosphatidylinositol-anchored cargo protein but not vesicular stomatitis virus G protein is transported through these two types of RE. In plants, there are two types of TGN-Golgi-associated TGN and Golgiindependent TGN. We show that dynamics of REs in both Drosophila and mammalian cells are very similar compared with those of plant TGNs. And, together with the similarity on the molecular level, our results indicate that fly and mammalian REs are organelles that are equivalent to TGNs in plants. This suggests that the identities and functional relationships between REs and TGNs should be reconsidered.

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trans-Golgi network-bound cargo traffic

Cited by 18 publications

References 235 publications

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

Wrong place at the wrong time: how retrograde trafficking drives cancer metastasis through receptor mislocalization

Recycling endosomes attach to the trans-side of Golgi stacks in Drosophila and mammalian cells

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