Trans-Sinus Dental Implants, Bone Morphogenetic Protein 2, and Immediate Function for All-on-4 Treatment of Severe Maxillary Atrophy

Jensen, Ole T.; Cottam, Jared R.; Ringeman, Jason L.; Adams, Mark W.

doi:10.1016/j.joms.2011.03.045

Cited by 41 publications

(36 citation statements)

References 19 publications

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“…Vague documentation of results Jensen et al 52 Case report Bedrossian 53 Zygoma implants Khatami and Smith 54 Case report Bedrossian 55 Zygoma implants Krekmanov et al 11 Number of implants/study design Butura et al 56 Case report Menini et al 33 Literature review Cannizzaro et al 57 Study design/no survival rates reported 64 Case report, zygoma implants Penarrocha-Oltra et al 65 Literature review Graves et al 66 Zygoma implants Pomares 67 Number of implants Graves et al 68 Zygoma implants Rosen and Gynther 69 Number of implants Jensen et al 70 Case report Wu et al 71 Language 74 Number of implants/study design Penarrocha-Oltra et al 75 Not tilted/study design Astrand et al 76 Number of implants/overdentures Pieri et al 77 Number of implants Eccelente et al 78 Removable prosthesis Pomares 79 Number of implants Ekelund et al 80 Number of implants Pomares 67 Number of implants Friberg and Jemt 81 Not tilted Romanos et al 82 Removable prosthesis Heschl et al 83 Removable prosthesis Wolfinger et al 84 Number of implants/study design Li et al 85 Number of implants/study design Wu et al 71 Language…”

Section: Outcome Measurementsmentioning

confidence: 99%

The All‐on‐Four Treatment Concept: A Systematic Review

Patzelt

Bahat

Reynolds

et al. 2013

Clin Implant Dent Rel Res

164

147

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The available data provide promising short-term results for the all-on-four treatment approach; however, current evidence is limited by the quality of available studies and the paucity of data on long-term clinical outcomes of 5 years or greater. In terms of an evidence-based dentistry, the authors recommend further studies designed as randomized controlled clinical trials and reported according to the CONSORT statement.

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Section: Outcome Measurementsmentioning

confidence: 99%

The All‐on‐Four Treatment Concept: A Systematic Review

Patzelt

Bahat

Reynolds

et al. 2013

Clin Implant Dent Rel Res

164

147

View full text Add to dashboard Cite

show abstract

“…This phenomenon is called osteoinduction, and of these molecules bone morphogenic protein (BMP) is one that has been extensively studied and has been shown to have significant impact on new bone formation, particularly BMP-2, BMP-4, and BMP-7. [1][2][3][4][5][6] Within autogenous bone grafts, the biological environment varies somewhat between cancellous and cortical graft. Cancellous grafts are less dense and, as such, the amount of necrosis and osteoclastic bone resorption necessary for vascular invasion is less.…”

Section: Biological Principlesmentioning

confidence: 99%

Surgical Techniques for Augmentation in the Horizontally and Vertically Compromised Alveolus

Doonquah

Lodenquai

Mitchell

2015

Dental Clinics of North America

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“…[1][2][3][4][5][6] Furthermore, clinical applications for rhBMP-2 have also been explored. [7][8][9] rhBMP-2 is a chemoattractant and migratory factor for mesenchymal stem cells (MSCs). rhBMP-2 plays an important role in regulating differentiation of MSCs into osteoblasts and also influences the angiogenic activity of MSCs.…”

Section: Introductionmentioning

confidence: 99%

Pulsed Electromagnetic Fields Enhance Bone Morphogenetic Protein-2 Dependent-Bone Regeneration

Yang

Kim

Hwang

2015

Tissue Engineering Part A

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The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for the purpose of promoting bone regeneration is emerging; however, the high dose of rhBMP-2 required in humans is accompanied by several limitations, including bone resorption and swelling. To reduce the dose of rhBMP-2 required, the applicability of pulsed electromagnetic fields (PEMF) was evaluated using a rat calvarial defect model. After creating an 8-mm-diameter calvarial bone defect, a collagen sponge soaked in different concentrations (0, 2.5, 5, 10 μg) of rhBMP-2 was implanted at the defect area. One week after surgery, PEMF was applied for 8 h/day over 5 days in an experimental group of animals (n = 28) using a width of 12 μs, a pulse frequency of 60 Hz, and a magnetic intensity of 10 G. Animals were sacrificed 4 weeks after surgery and assessed by microcomputed tomography and histological and immunohistochemical analyses. In the absence of application of PEMF, bone volume, bone mineral density, trabecular thickness, trabecular number, and trabecular separation, all showed statistically significant differences, depending on the concentration of rhBMP-2 utilized (p < 0.001). PEMF accelerated bone regeneration in the groups that received 0, 2.5, and 5 μg rhBMP-2 (p < 0.05). In contrast, administration of 10 μg rhBMP-2 resulted in no additive effect on bone regeneration in combination with PEMF. Groups receiving no rhBMP-2 showed distinct bone regeneration in the central zone of the bone defect when treated with PEMF, whereas they failed to bridge the defect space without PEMF. Among the groups without PEMF, soft tissue infiltrations from the outer surface on the skin side were common. Among groups with PEMF, the groups receiving 5 and 10 μg rhBMP-2 displayed denser bone with significantly reduced dead spaces. The application of PEMF did not result in an accelerated effect on bone regeneration in groups treated with 10 μg rhBMP-2. Therefore, our data demonstrate that PEMF can promote bone regeneration in animals treated with a low concentration of rhBMP-2.

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Trans-Sinus Dental Implants, Bone Morphogenetic Protein 2, and Immediate Function for All-on-4 Treatment of Severe Maxillary Atrophy

Cited by 41 publications

References 19 publications

The All‐on‐Four Treatment Concept: A Systematic Review

The All‐on‐Four Treatment Concept: A Systematic Review

Surgical Techniques for Augmentation in the Horizontally and Vertically Compromised Alveolus

Pulsed Electromagnetic Fields Enhance Bone Morphogenetic Protein-2 Dependent-Bone Regeneration

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