Transcatheter Aortic Valve Thrombogenesis: A Foreign Materials Perspective

Salim, Tausif; Sadri, Vahid; Nair, Priya; Schwaner, Daniel; Apte, Mugdha; Yoganathan, Ajit P.

doi:10.1007/s13239-020-00505-8

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…This evidence is not conclusive, however, and does not suggest that the TAV causes no disruption to the endothelium, only that it is less disruptive than AS. An ex vivo blood loop study by Salim et al [58] attempted to isolate the thrombogenic contributions of the Table 3. Summary of studies regarding blood biochemistry, foreign materials and endothelial damage.…”

Section: Foreign Materials and Endothelial Damagementioning

confidence: 99%

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Transcatheter aortic valve thrombosis: a review of potential mechanisms

Raghav

Midha

Sharma

et al. 2021

J. R. Soc. Interface.

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Transcatheter aortic valve (TAV) thrombosis has been recognized as a significant problem that sometimes occurs as early as within 30 days after valve implantation, leading to increased concerns of stroke and long-term valve durability. In this article, a critical summary of the relevant literature on identifying potential mechanisms of TAV thrombosis from the perspective of the well-known Virchow's triad, which comprises blood flow, foreign materials and blood biochemistry, is presented. Blood flow mechanisms have been the primary focus thus far, with a general consensus on the flow mechanisms with respect to haemodynamic conditions, the influence of TAV placement and expansion and the influence of coronary flow. Less attention has been paid to the influence of blood biochemistry and foreign materials (and related endothelial damage), with little consensus among studies with regards to platelet and/or microparticle levels post-TAV implantation. Finally, we discuss the future outlook for research with unanswered scientific questions.

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Section: Foreign Materials and Endothelial Damagementioning

confidence: 99%

“…Horn et al[57] Levels of endothelial microparticles decreased after TAVI (CD31+/41−: 258 MP µl −1 versus 216 MP µl −1 ; CD144+: 349 MP µl versus 275 MP µl −1 and CD62E+: 1218 MP µl −1 versus 960 MP µl −1 ). Salim et al[58]…”

mentioning

confidence: 99%

Transcatheter aortic valve thrombosis: a review of potential mechanisms

Raghav

Midha

Sharma

et al. 2021

J. R. Soc. Interface.

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Effect of Ascending Aortic Curvature on Flow in the Sinus and Neo-sinus Following TAVR: A Patient-Specific Study

Kim,

Sadri,

Chen

et al. 2023

Ann Biomed Eng

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Special Issue on Professor John M. Tarbell’s Contribution to Cardiovascular Engineering

Manning

Tarbell

2021

Cardiovasc Eng Tech

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Professor John M. Tarbell's contributions to the biomedical engineering community have been substantial through service, education, and research. These contributions have spanned approximately 45 years with his research efforts impactful in areas of mechanical heart valves, artificial hearts, cardiovascular fluid mechanics, vascular permeability, and mechanobiology. Professor Tarbell's legacy goes well beyond just his own research efforts, and this special issue of Cardiovascular Engineering and Technology celebrates his impact through collaborators, trainees, and close colleagues. To celebrate the lifetime achievement of Professor Tarbell, his former trainees, collaborators and colleagues have contributed ten papers including two review papers on the areas of artificial heart, heart valves, glycocalyx, and endothelial permeability to macromolecules and therapeutics in this Special Issue of Cardiovascular Engineering and Technology. Here, we first introduce each paper and Professor Tarbell reflects on his professional success, which continues today. The papers collected in this Special Edition are grouped into the areas of (1) mechanical heart valve, artificial hearts, and heart valves, (2) the glycocalyx, (3) endothelial permeability, and (4) endothelial gene and drug delivery.

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Transcatheter Aortic Valve Thrombogenesis: A Foreign Materials Perspective

Cited by 4 publications

References 23 publications

Transcatheter aortic valve thrombosis: a review of potential mechanisms

Transcatheter aortic valve thrombosis: a review of potential mechanisms

Effect of Ascending Aortic Curvature on Flow in the Sinus and Neo-sinus Following TAVR: A Patient-Specific Study

Special Issue on Professor John M. Tarbell’s Contribution to Cardiovascular Engineering

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