Transcatheter arterial chemoembolization in combination with radiotherapy for unresectable hepatocellular carcinoma: A systematic review and meta-analysis

Meng, Maobin; Cui, Yujia; Lü, You; She, Bin; Chen, Yan; Guan, Yong-Song; Zhang, Ruiming

doi:10.1016/j.radonc.2008.11.002

Cited by 134 publications

(106 citation statements)

References 49 publications

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“…The efficacy of TACE plus radiotherapy has been studied in 12 non-randomized and 5 randomized controlled trials in Korea, Japan, and China. A meta-analysis of these trials showed significantly improved survival at 1 year (OR = 2.23, 95%CI: 1.76-2.83) and 5 years (OR = 4.47, 95%CI: 2.08-9.61) and a better tumor response (OR = 2.58, 95%CI: 1.64-4.06) in patients receiving TACE plus radiotherapy compared with patients receiving TACE alone [144] . In this analysis, most although not all patients in the individual studies had intermediate stage HCC.…”

Section: Tace Combined With Rfa or Radiotherapymentioning

confidence: 99%

“…These efficacy data seem encouraging, but further investigations are warranted. [100,144] , whereas studies of advanced stage HCC only are few [157,158] . A retrospective study assessed outcome of patients with locally advanced HCC; 27 patients who were treated with TACE plus radiotherapy and another 27 patients who received sorafenib alone were compared after propensity score matching.…”

Section: Sorafenib Combined With Tacementioning

confidence: 99%

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Current management of hepatocellular carcinoma: An Eastern perspective

Yim¹

2015

WJG

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Section: Tace Combined With Rfa or Radiotherapymentioning

confidence: 99%

Section: Sorafenib Combined With Tacementioning

confidence: 99%

Current management of hepatocellular carcinoma: An Eastern perspective

Yim¹

2015

WJG

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“…Nowadays, radiotherapy plays an important role in the treatment of unresectable or inoperable HCC 3 , 4 . Combined with transcatheter arterial chemoembolization (TACE), which is the first choice for patients with unresectable HCC, radiotherapy can improve the survival of the unresectable HCC patients 5 , 6 , 7 . IMRT and 3D CRT can provide conformal dose distribution, while geometrical uncertainties in treatments influence the actually delivered dose distribution.…”

Section: Introductionmentioning

confidence: 99%

Inter‐ and intrafractional setup errors and baseline shifts of fiducial markers in patients with liver tumors receiving free‐breathing postoperative radiation analyzed by cone‐beam computed tomography

Zhang

Wang

et al. 2014

J Applied Clin Med Phys

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This study was to evaluate the interfractional and intrafractional setup errors and baseline shifts of golden fiducial markers in patients receiving postoperative radiotherapy (RT) using cone‐beam computed tomography (CBCT) in order to calculate PTV margins for patients with liver cancer. Twelve patients with liver tumors underwent postoperative RT. CBCT images were acquired before and after the treatment. Off‐line vertebral body match and fiducial marker match were used, respectively. The results of vertebral body match represented the setup errors of the patients, while the results of fiducial marker match represented the absolute position errors of the target volume. Baseline shifts of the target volume were calculated as the absolute target position errors minus setup errors. A total of 12 patients with 214 acquisitions of CBCTs were analyzed. Both Σ and σ of setup errors and baseline shifts in left–right (L/R), superior–inferior (S/I), and anterior–posterior(A/P) directions were calculated, including interfractional and intrafractional uncertainties. Planning target volume (PTV) margins were calculated according to margin=2.5Σ+0.7σ. Margins of 1.8 mm, 3.8 mm, and 1.4 mm in L/R, S/I, and A/P directions are needed to compensate intrafractional errors when daily online CBCT correction is used. When CBCT correction with no action level (NAL) protocol is used, PTV margin should be 2.6 mm, 5.9 mm, and 2.6 mm in L/R, S/I, and A/P directions. Margins of 5.5 mm, 14.6 mm, and 7.2 mm were needed to compensate the baseline shifts when electronic portal imaging devices (EPID) or CBCT with bone match is used for online correction of setup error.PACS number: 87.55.‐x

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“…There have been multiple reports previously suggesting synergism. 35 Studies evaluating concurrent chemotherapy or sequential TACE are underway. 36,37 To conclude adoption of radiotherapy as a standard care in treatment of hepatocellular carcinoma awaits data from prospective trials.…”

Section: Role For Radiotherapymentioning

confidence: 99%

Role of External Beam Radiation Therapy in Management of Hepatocellular Carcinoma

Sharma

2014

Journal of Clinical and Experimental Hepatology

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Diagnosis at advanced disease stage and early vascular invasion are the bane of majority of patients with hepatocellular carcinoma (HCC) in India. The currently standardized curative and palliative treatment modalities [surgery, ablative techniques, trans-catheter chemotherapy, systemic chemotherapy] are suboptimal for a significant proportion of disease stages. Interest in radiotherapy for hepatocellular carcinoma has seen a resurgence with revolutionary improvements in targeting radiation doses safely. Encouraging results have been reported with a host of radiation techniques from conformal radiotherapy, stereotactic whole body radiation therapy to charged particle based therapies. The dissemination of this knowledge has been slow across other specialties involved in care of patients with HCC. However the increasing availability of radiotherapy services predicts a hopeful future for wider evaluation of radiotherapy in HCC. ( J CLIN EXP HEPATOL 2014;4:S122-S125)

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Transcatheter arterial chemoembolization in combination with radiotherapy for unresectable hepatocellular carcinoma: A systematic review and meta-analysis

Cited by 134 publications

References 49 publications

Current management of hepatocellular carcinoma: An Eastern perspective

Current management of hepatocellular carcinoma: An Eastern perspective

Inter‐ and intrafractional setup errors and baseline shifts of fiducial markers in patients with liver tumors receiving free‐breathing postoperative radiation analyzed by cone‐beam computed tomography

Role of External Beam Radiation Therapy in Management of Hepatocellular Carcinoma

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