Transconjunctival immunotherapy using cholera toxin B to treat experimental allergic conjunctivitis in a mouse model

Abstract

Transconjunctival immunotherapy using CTB can be evaluated by histological examination of eosinophils and CD4-positive T cells, and a mucosal immunity-associated chemokine and a helper T-cell-17-associated chemokine as biomarkers.

The Cholera Toxin as a Biotechnological Tool

“…Oral administration of allogeneic antigen linked to CTB induced immunological tolerance against allograft rejection [Sun et al, 2000a]. Finally, transconjunctival immunotherapy using CTB could suppress clinical effects for experimental allergic conjunctivitis in guinea pigs [Oikawa et al, 2011].…”