2018
DOI: 10.1371/journal.pone.0204842
|View full text |Cite
|
Sign up to set email alerts
|

Transcortical photothrombotic pyramidotomy model with persistent motor deficits

Abstract: Traditional pyramidotomy models have a high mortality rate from breathing difficulties and show early recovery from the induced motor deficits. This study establishes a novel pyramidotomy technique in Sprague Dawley rats that generates persistent motor deficits and has a reduced mortality rate. We used viral neural tracing to identify the course and relative distribution of forelimb and hindlimb motor fibers (n = 9). On basis of the neural tracing data, the medullary pyramid was targeted dorsally from the cere… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2021
2021
2021
2021

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 16 publications
0
1
0
Order By: Relevance
“…Animal models are suitable platforms for conducting such studies [ 31 ]. Spastic CP correlated with injury of the cortex and subcortical white matter [ 32 34 ]. Many well-known and widely used animal models of spastic CP either show typical spastic CP-like phenotypes or overlook depression-like behaviour [ 35 , 36 ].…”
Section: Introductionmentioning
confidence: 99%
“…Animal models are suitable platforms for conducting such studies [ 31 ]. Spastic CP correlated with injury of the cortex and subcortical white matter [ 32 34 ]. Many well-known and widely used animal models of spastic CP either show typical spastic CP-like phenotypes or overlook depression-like behaviour [ 35 , 36 ].…”
Section: Introductionmentioning
confidence: 99%