Transcranial color coded sonography: advanced approach using ultrasound fusion imaging

Schreiber, Stephan J.; Valdueza, José M.; Doepp, Florian

doi:10.21035/ijcnmh.2014.1(suppl.1).s16

Cited by 6 publications

(6 citation statements)

References 8 publications

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“…Indeed, the inter-observer agreement has changed from good to excellent without this criterion. Nevertheless, considering this criterion important for a better assessment of cerebral hemodynamic this problem could be overcome with use of MRI-ultrasound fusion techniques 53 only in selected cases (post-surgical monitoring, patients with positivity of a single criterion evaluated by the revised protocol for CCSVI screening).…”

Section: Resultsmentioning

confidence: 99%

New Criteria Reduce Inter-Observer Variability in Chronic Cerebrospinal Venous Insufficiency: A Case Control Study

Farina¹,

Novelli²,

Pagani³

2017

Neuro – Open Journal

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Background: The pathophysiological mechanism defined "chronic cerebrospinal venous insufficiency" (CCSVI) diagnosed using Zamboni criteria has raised a heated debate about possible correlations with several neurological disorders, but also on subjectivity of these ultrasonographic criteria used for its diagnosis. Although in 2011 new criteria have been introduced to reduce the high inter-observer variability only two studies were conducted according to the new investigation protocol. Therefore, we wanted to verify the impact of the revised protocol and its ability to meet the demand for reduction of the high heterogeneity in inter-observer agreement. Patients and Methods: Between June 2010 and June 2014, 1020 subjects (693 MS patients and 327 HCs) were prospectively screened for CCSVI by two investigators, blinded regarding the observed subject. After exclusion of discordant cases between the two examiners, 630 patients with clinically defined MS and 10 patients with CIS (clinically isolated syndrome) were matched by gender (male 38.7%, male/female 248/392) and age (mean age 44.0 years, range 18.5-77.0 years) with 315 HCs (male 43.2%, male/female 136/179-mean age 46.5 years, range 19.8-79.9 years). Results: The prevalence of CCSVI in MS subjects before the introduction of the new ECD criteria (94.3%) was observed to be significantly reduced (83.4%) after their introduction (p<0.001). In MS patients, the strength of inter-observer agreement changed from moderate (k=0.532) to good (k=0.761) before/after the revision. B-mode analysis detected only 65.7% of valvular defects. Its diagnostic accuracy was 88.6% (95% CI: 84.0%-93.2%), with a sensitivity of 83.5% (95% CI: 75.2%-89.9%), a specificity of 96.0% (95% CI: 88.8%-99.2%), a positive predictive value of 96.8% (95% CI: 91.0%-99.3%) and a negative predictive value of 80.0% (95% CI: 70.3%-87.7%). Conclusions:The new ECD criteria introduced by the revised protocol ensure, at this time, a substantial reduction of the inter-observer variability. Under this perspective, M-mode analysis is essential for its ability to identify the valvular abnormalities frequently not detectable by Bmode analysis.

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Section: Resultsmentioning

confidence: 99%

New Criteria Reduce Inter-Observer Variability in Chronic Cerebrospinal Venous Insufficiency: A Case Control Study

Farina¹,

Novelli²,

Pagani³

2017

Neuro – Open Journal

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“…The possibility of using of this technology was published recently 11,12 . DCVs and sinuses are located at a depth of 6-8 cm from the US probe, their diameter is only 2-4 mm, and they run parallel to the skull) (ref.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the cavernous sinus is located close to the nasal space, and the respiration air flow may imitate the venous blood flow. Fusion imaging technology is able to help with the correct detection of venous blood flow due to real-time fusion of MRI and TCCS images, where the venous system was imaged using brain MRI and venous blood flow was encoded to the MRI image using the color Doppler mode 8,11,12 . The accuracy of the system measured using a registration pen was excellent (< 1 mm) with the root mean square error < 0.5 cm.…”

Section: Discussionmentioning

confidence: 99%

Comparison of brain vessel imaging from transtemporal and transcondylar approaches using contrast-enhanced transcranial color-coded duplex sonography and Virtual Navigator

Školoudík¹,

Kuliha²,

Roubec³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims. The transcondylar approach is a new and used for detection of chronic cerebro-spinal venous insufficiency (CCSVI) and intracranial venous reflux in patients with multiple sclerosis. The aim of this study was to assess the ability of native and contrast enhanced (CE-) transcranial color-coded duplex sonography (TCCS) to detect flow and reflux in deep cerebral veins and intracranial venous sinuses from transcondylar and transtemporal approaches. Methods. Brain magnetic resonance imaging and TCCS from transtemporal and transcondylar approaches using the new technology -Fusion Imaging -in 8 volunteers and 5 patients with multiple sclerosis. Results. Using TCCS and CE-TCCS, the arteries of the circle of Willis could be detected from the transtemporal approach in 13/13 subjects in both examinations, while detection of the venous system was possible in 7/13 and 9/13 subjects, respectively. However, the arteries of the circle of Willis and venous system were detected through the transcondylar approach in only 5/13 (P=0.041) and 1/13 (P=0.031) subjects using TCCS, and in 12/13 (P=0.921) and 7/13 (P=0.687) subjects using CE-TCCS, respectively. Conclusions. The results reveal that the TCCS transcondylar approach has serious limitations for the standard detection of intracranial venous reflux.

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“…[5] Recent publications reported its new application in neurosonology for diagnostics and teaching. [6,7]…”

Section: Introductionmentioning

confidence: 99%

Ultrasound fusion imaging system in neurology practice

Peycheva¹,

Chervenkov²,

Harizanova³

et al. 2022

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The ultrasound fusion imaging (UFI) system is a new promising imaging modality that combines live ultrasound investigations with preregistered CT, MRI, or PET images. In this study, we want to present our initial experience with the new method that combines the transcranial color-coded sonography (TCCS) in different insonation planes and the 3T-weighted MRI cerebral images. The study validates the diagnostic capabilities of the system to detect different normal cerebral structures in healthy volunteers. In the present paper, we also discuss the advantages of US fusion imaging technology and its clinical applications in Neurology.

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Transcranial color coded sonography: advanced approach using ultrasound fusion imaging

Cited by 6 publications

References 8 publications

New Criteria Reduce Inter-Observer Variability in Chronic Cerebrospinal Venous Insufficiency: A Case Control Study

New Criteria Reduce Inter-Observer Variability in Chronic Cerebrospinal Venous Insufficiency: A Case Control Study

Comparison of brain vessel imaging from transtemporal and transcondylar approaches using contrast-enhanced transcranial color-coded duplex sonography and Virtual Navigator

Ultrasound fusion imaging system in neurology practice

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