Transcranial Direct Current Stimulation for Refractory Auditory Hallucinations in Schizophrenia

Andrade, Chittaranjan

doi:10.4088/jcp.13f08826

Cited by 35 publications

(21 citation statements)

References 40 publications

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“…tDCS may represent a well tolerated, inexpensive and promising treatment for antipsychoticrefractory VAH [39], although its putative efficacy is based on only one RCT [40]. Interestingly, the effect of tDCS on VAH may last longer than that of rTMS, and tDCS may also be effective for negative symptoms [40].…”

Section: Discussionmentioning

confidence: 99%

Schizophrenia

Miyamoto

Jarskog²,

Fleischhacker

2015

Current Opinion in Psychiatry

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There is currently insufficient evidence for efficacy of pharmacological augmentation strategies to clozapine. ECT may be a promising option, but further research is necessary to confirm its long-term effects. Moreover, further controlled studies are warranted to clarify the potential of other biological and psychosocial approaches to serve as adjuvant treatments in patients with clozapine-resistant TRS.

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Section: Discussionmentioning

confidence: 99%

Schizophrenia

Miyamoto

Jarskog²,

Fleischhacker

2015

Current Opinion in Psychiatry

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“…A naturalistic study in 14 children with language disorders showed that 10 sessions of tDCS were well tolerated and the main side effect detected was irritability, followed by acute mood changes, tingling and itching [36] . However, due to anatomical and neurophysiological differences in the developing brain (i.e., skull thickness, cerebrospinal fluid volume, white and gray matter volumes) the dose parameters considered safe and efficacious for the use in adults should be adjusted to achieve comparable results in children [37] .…”

Section: Tdcs In the Major Depressive Disordermentioning

confidence: 99%

Transcranial direct current stimulation in psychiatric disorders

Tortella¹,

Casati²,

Aparicio³

et al. 2015

WJP

138

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The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation (tDCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally, REVIEWSubmit a

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“…It is a safe and relatively inexpensive form of neurostimulation with clinically negligible adverse effects. tDCS with the cathode sited over the left TPC and the anode sited over the left DLPFC has been used for the treatment of medication-resistant AVH and for attenuation of negative symptom in schizophrenia [61]. Twice-daily tDCS with the above protocol has been found attenuate medication-refractory AVH in a randomized, sham controlled trial [62].…”

Section: Combining Tdcs With Clozapinementioning

confidence: 99%

Efficacy and safety of combining clozapine with electrical or magnetic brain stimulation in treatment-refractory schizophrenia

Arumugham

Thirthalli

Andrade

2016

Expert Review of Clinical Pharmacology

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We conducted a systematic literature search through Pubmed and cross-references for relevant publications evaluating the safety and efficacy of combining BST with clozapine. Expert commentary: Evidence from a randomized controlled trial and open-label trials suggest that ECT is an effective intervention in clozapine-refractory schizophrenia. There is limited evidence that the combination is safe. However, until sufficient data accumulate, it would be prudent to be vigilant against adverse effects related to lowered seizure threshold, cognitive impairment, and cardiovascular events. Both high frequency rTMS over the dorsolateral prefrontal cortex and low frequency rTMS over the temporoparietal cortex have been safely administered in patients receiving clozapine. However, rTMS efficacy in clozapine-refractory patients remains uncertain. The evidence for tDCS-clozapine combination is in the form of case reports and needs to be evaluated in controlled trials. Newer methods of brain stimulation and refinement of existing BSTs hold promise for the future.

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Transcranial Direct Current Stimulation for Refractory Auditory Hallucinations in Schizophrenia

Cited by 35 publications

References 40 publications

Schizophrenia

Schizophrenia

Transcranial direct current stimulation in psychiatric disorders

Efficacy and safety of combining clozapine with electrical or magnetic brain stimulation in treatment-refractory schizophrenia

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