Transcranial direct current stimulation in children and adolescents: a comprehensive review

Palm, Ulrich; Segmiller, Felix; Epple, Ann Natascha; Freisleder, Franz-Joseph; Koutsouleris, Nikolaos; Schulte‐Körne, Gerd; Padberg, Frank

doi:10.1007/s00702-016-1572-z

Cited by 86 publications

(74 citation statements)

References 105 publications

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“…However, there are some general and specific points that need to be considered depending on NIBS protocol and the study population (e.g., healthy volunteers or patients). Safety issues on the use of rTMS and tDCS in adults and adolescents are reviewed extensively elsewhere (Rossi et al, 2009; Krishnan et al, 2015; Bikson et al, 2016; Palm et al, 2016) and are summarized below, as a full description of them is beyond the scope of this review article.…”

Section: Nibs Modulation Of Oscillatory Activitiesmentioning

confidence: 99%

Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation

Assenza

Capone

Biase

et al. 2017

Front. Aging Neurosci.

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Non-invasive brain stimulation (NIBS) has been under investigation as adjunct treatment of various neurological disorders with variable success. One challenge is the limited knowledge on what would be effective neuronal targets for an intervention, combined with limited knowledge on the neuronal mechanisms of NIBS. Motivated on the one hand by recent evidence that oscillatory activities in neural systems play a role in orchestrating brain functions and dysfunctions, in particular those of neurological disorders specific of elderly patients, and on the other hand that NIBS techniques may be used to interact with these brain oscillations in a controlled way, we here explore the potential of modulating brain oscillations as an effective strategy for clinical NIBS interventions. We first review the evidence for abnormal oscillatory profiles to be associated with a range of neurological disorders of elderly (e.g., Parkinson’s disease (PD), Alzheimer’s disease (AD), stroke, epilepsy), and for these signals of abnormal network activity to normalize with treatment, and/or to be predictive of disease progression or recovery. We then ask the question to what extent existing NIBS protocols have been tailored to interact with these oscillations and possibly associated dysfunctions. Our review shows that, despite evidence for both reliable neurophysiological markers of specific oscillatory dis-functionalities in neurological disorders and NIBS protocols potentially able to interact with them, there are few applications of NIBS aiming to explore clinical outcomes of this interaction. Our review article aims to point out oscillatory markers of neurological, which are also suitable targets for modification by NIBS, in order to facilitate in future studies the matching of technical application to clinical targets.

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Section: Nibs Modulation Of Oscillatory Activitiesmentioning

confidence: 99%

Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation

Assenza

Capone

Biase

et al. 2017

Front. Aging Neurosci.

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“…As such, it has been recommended that brain stimulation for pure cognitive enhancement should be delayed until the patient has reached the state of intellectual maturity (Maslen et al, 2015). However, since tDCS can produce positive results in various psychiatric patients, the use of tDCS among children and adolescents who need treatment has been explored (Fiocchi et al, 2016; Gschwind and Seeck, 2016; Muszkat et al, 2016; Palm et al, 2016). …”

Section: Possible Adverse Effects and Safety Proceduresmentioning

confidence: 99%

Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns

et al. 2017

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Transcranial direct current stimulation (tDCS) is a widely-used tool to induce neuroplasticity and modulate cortical function by applying weak direct current over the scalp. In this review, we first introduce the underlying mechanism of action, the brief history from discovery to clinical scientific research, electrode positioning and montages, and parameter setup of tDCS. Then, we review tDCS application in clinical samples including people with drug addiction, major depression disorder, Alzheimer's disease, as well as in children. This review covers the typical characteristics and the underlying neural mechanisms of tDCS treatment in such studies. This is followed by a discussion of safety, especially when the current intensity is increased or the stimulation duration is prolonged. Given such concerns, we provide detailed suggestions regarding safety procedures for tDCS operation. Lastly, future research directions are discussed. They include foci on the development of multi-tech combination with tDCS such as with TMS and fMRI; long-term behavioral and morphological changes; possible applications in other research domains, and more animal research to deepen the understanding of the biological and physiological mechanisms of tDCS stimulation.

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“…Regarding the functional effects of tDCS in healthy children, some studies on cognitive, motor, and learning processes have been performed (Palm et al, 2016). In a recent study, Ciechanski and Kirton (in press) Table 1).…”

Section: Healthy Childrenmentioning

confidence: 99%

Applications of transcranial direct current stimulation in children and pediatrics

Rivera-Urbina¹,

Nitsche

Vicario

et al. 2016

Reviews in the Neurosciences

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AbstractTranscranial direct current stimulation (tDCS) is a neuromodulatory noninvasive brain stimulation tool with potential to increase or reduce regional and remote cortical excitability. Numerous studies have shown the ability of this technique to induce neuroplasticity and to modulate cognition and behavior in adults. Clinical studies have also demonstrated the ability of tDCS to induce therapeutic effects in several central nervous system disorders. However, knowledge about its ability to modulate brain functions in children or induce clinical improvements in pediatrics is limited. The objective of this review is to describe relevant data of some recent studies that may help to understand the potential of this technique in children with specific regard to effective and safe treatment of different developmental disorders in pediatrics. Overall, the results show that standard protocols of tDCS are well tolerated by children and have promising clinical effects. Nevertheless, treatment effects seem to be partially heterogeneous, and a case of a seizure in a child with previous history of infantile spasms and diagnosed epilepsy treated with tDCS for spasticity was reported. Further research is needed to determine safety criteria for tDCS use in children and to elucidate the particular neurophysiological changes induced by this neuromodulatory technique when it is applied in the developing brain.

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Transcranial direct current stimulation in children and adolescents: a comprehensive review

Cited by 86 publications

References 105 publications

Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation

Oscillatory Activities in Neurological Disorders of Elderly: Biomarkers to Target for Neuromodulation

Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns

Applications of transcranial direct current stimulation in children and pediatrics

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