Transcranial Direct Current Stimulation Over the Prefrontal Cortex in Depression Modulates Cortical Excitability in Emotion Regulation Regions as Measured by Concurrent Functional Magnetic Resonance Imaging: An Exploratory Study

Chrysikou, E; Wing, Erik K.; Dam, Wessel O. van

doi:10.1016/j.bpsc.2019.12.004

Cited by 16 publications

(15 citation statements)

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“…Amongst them, we did not receive a response from the corresponding author about the missing data in one study [ 43 ], and the authors of other study were unable to provide data until three months later due to isolation [ 69 ]. Finally, 17 studies were included in the meta-analysis [ 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 ]. Each of included studies had the condition of downregulate negative emotions in study procedure, but two of them did not have the condition of maintenance of negative emotions [ 53 , 77 ].…”

Section: Resultsmentioning

confidence: 99%

“…In addition, 150 of the participants had a psychiatric disorder, including 39 with AUD, 39 with depression, 33 with internet gaming disorder, and 39 with OCD, while the other participants were healthy. Four studies used HF-rTMS [ 47 , 51 , 52 , 70 ], of which one study used LF-rTMS also [ 52 ], one study used single-pulse TMS [ 48 ], one study used cTBS [ 49 ], and 11 studies used tDCS [ 50 , 53 , 54 , 55 , 71 , 72 , 73 , 74 , 75 , 76 , 77 ]. Materials from the above studies included pictures or emotional stimulus which only induced negative emotions.…”

Section: Resultsmentioning

confidence: 99%

“…This indicates that NIBS may not significantly promote the use of explicit emotion regulation strategies, but promote the downregulation of negative emotions by reducing negative emotional responses. In fact, few behavioral studies documented a positive effect of NIBS on the emotion regulation strategies [ 51 , 72 , 74 , 75 , 76 ]. Neuroimaging studies of NIBS also indicated that the increased DLPFC activity was independent of emotion regulation strategies [ 52 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

“… Results of the meta-analyses for overall NIBS studies. (a–d) Different effect sizes from the same study [ 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 ]. …”

Section: Figurementioning

confidence: 99%

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The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

Zhang

Liu

et al. 2022

Brain Sciences

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(1) Background: Emotion regulation (ER) is regarded as a core treatment target for depression and other mental illnesses. In recent years, non-invasive brain stimulation (NIBS) has been extensively used as an intervention for mental illnesses, but there has been no systematic review conducted regarding its effect on emotion regulation. Therefore, we conducted a meta-analysis of the effectiveness of NIBS for emotion regulation; (2) Methods: Systematic searches were conducted in Embase, Web of Science, PubMed, and Cochrane Library. We analyzed the effects of NIBS on tasks assessing emotion regulation using a random-effects model, and further explored the moderating role of the following factors on transcranial direct current stimulation (tDCS) studies by conducting subgroup analyses and meta-regression: target electrode placement, return electrode placement, current intensity, target electrode size, and duration of intervention; (3) Results: A total of 17 studies were included. Our meta-analysis indicated a small but significant effect of NIBS on the downregulation of negative emotions. Separate analyses indicated that repetitive transcranial magnetic stimulation (rTMS) had a medium and significant effect on the downregulation of negative emotions, whereas tDCS had no significant effect. Subgroup analyses showed that the effect of tDCS was moderated by target and return electrode placemen; (4) Conclusions: These results indicate that NIBS had a positive effect on the downregulation of negative emotions. The stimulation protocols should be carefully considered and the underlying mechanisms should be further explored.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

Zhang

Liu

et al. 2022

Brain Sciences

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“…Although most tDCS studies have focused on the stimulation effects of primary motor and dorsolateral prefrontal cortices ( Nitsche et al, 2003 ; Fregni et al, 2005 , 2008 ; Antal et al, 2011 ; Ahn et al, 2017 ; Lefaucheur et al, 2017 ; Vanderhasselt et al, 2017 ; Angius et al, 2019 ; Shilo and Lavidor, 2019 ; Chrysikou et al, 2019 ; Gallucci et al, 2020 ), there is evidence that tDCS of the somatosensory cortices can also elicit neurophysiological and psychological after-effects on body processing ( Antal et al, 2006 , 2008 ; Dieckhöfer et al, 2006 ; Lenoir et al, 2017 ; Saito et al, 2019 ). Previous research has established that anodal tDCS of the somatosensory cortex elicits brain hyperexcitability, significant enhancement of pain thresholds ( Matsunaga et al, 2004 ; Antal et al, 2008 ; Grundmann et al, 2011 ; Vaseghi et al, 2015 ), and tactile spatial acuity ( Ragert et al, 2008 ; Fujimoto et al, 2014 , 2016 ), whereas cathodal tDCS can reduce the responsiveness of the primary somatosensory cortex to painful and non-painful stimuli ( Grundmann et al, 2011 ; Lenoir et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Somatosensory Gating Is Modulated by Anodal Transcranial Direct Current Stimulation

et al. 2021

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BackgroundAnodal transcranial direct current stimulation (tDCS) of the somatosensory cortex causes cerebral hyperexcitability and a significant enhancement in pain thresholds and tactile spatial acuity. Sensory gating is a brain mechanism to suppress irrelevant incoming inputs, which is elicited by presenting pairs of identical stimuli (S1 and S2) within short time intervals between stimuli (e.g., 500 ms).Objectives/HypothesisThe present study addressed the question of whether tDCS could modulate the brain correlates of this inhibitory mechanism.MethodsForty-one healthy individuals aged 18–26 years participated in the study and were randomly assigned to tDCS (n = 21) or SHAM (n = 20). Somatosensory evoked potentials (SEP) elicited by S1 and S2 pneumatic stimuli (duration of 100 ms, ISI 550 ± 50 ms) and applied to the index finger of the dominant hand were recorded before and after tDCS.ResultsBefore the intervention, the second tactile stimuli significantly attenuated the amplitudes of P50, N100, and the late positive complex (LPC, mean amplitude in the time window 150–350) compared to the first stimuli. This confirmed that sensory gating is a widespread brain inhibitory mechanism that can affect early- and middle-latency components of SEPs. Furthermore, our data revealed that this response attenuation or sensory gating (computed as S1 minus S2) was improved after tDCS for LPC, while no changes were found in participants who received SHAM.ConclusionAll these findings suggested that anodal tDCS might modulate brain excitability leading to an enhancement of inhibitory mechanisms elicited in response to repetitive somatosensory stimuli during late stages of information processing.

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Augmenting the unified protocol with transcranial direct current stimulation: Effects on emotion regulation and executive dysfunction

Nasiri

Ellard

Մաշհադի

et al. 2022

Clin Psychology and Psychoth

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The aim of the current study was to compare the unified protocol for transdiagnostic treatment of emotional disorders (UP) with and without transcranial direct current stimulation (tDCS) for the treatment of emotion regulation and executive control dysfunction in individuals diagnosed with generalized anxiety disorder (GAD) and comorbid major depressive disorder (MDD). A total of 43 individuals with GAD and co‐morbid MDD were randomly assigned to three groups including UP with tDCS (UP+tDCS; n = 15), UP alone (UP; n = 13) or wait‐list control (n = 15). Difficulties in emotion regulation, reappraisal, suppression, inhibition and working memory were assessed at baseline, post‐treatment and 3‐month follow‐up. Treatment with both UP+tDCS and UP alone resulted in significant improvements in difficulties in emotion regulation, cognitive reappraisal, and working memory, and significant reductions in suppression and inhibition relative to wait‐list controls at post‐treatment and 3‐month follow‐up. Relative to UP alone, UP+tDCS showed significantly greater improvements in difficulties in emotion regulation, cognitive reappraisal, inhibition, and working memory at post‐treatment and 3‐month follow‐up. These results suggest combination of UP treatment with tDCS may be an efficacious intervention to improve emotion regulation and executive function in GAD with co‐morbid MDD. Trial registration reference is IRCT20140929019334N1 (see https://irct.ir/trial/27988).

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Transcranial Direct Current Stimulation Over the Prefrontal Cortex in Depression Modulates Cortical Excitability in Emotion Regulation Regions as Measured by Concurrent Functional Magnetic Resonance Imaging: An Exploratory Study

Cited by 16 publications

References 55 publications

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

Somatosensory Gating Is Modulated by Anodal Transcranial Direct Current Stimulation

Augmenting the unified protocol with transcranial direct current stimulation: Effects on emotion regulation and executive dysfunction

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