Transcranial direct-current stimulation protects against cerebral ischemia-reperfusion injury through regulating Cezanne-dependent signaling

Cheng, Jing; Fan, Yanqin; Jiang, Hongxiang; Chen, Songfeng; Chen, Juan; Liao, Xinyu; Zou, Yongchao; Lan, Hangzhen; Cui, Yu; Chen, Zhibiao; Chen, Qianxue; Wan, Qi

doi:10.1016/j.expneurol.2021.113818

Cited by 16 publications

(20 citation statements)

References 41 publications

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“…After duplicate removal and title-abstract screening, 45 studies were selected to determine their eligibility. After excluding 37 studies, eight studies ( Kim et al, 2010 ; Yoon et al, 2012 ; Peruzzotti-Jametti et al, 2013 ; Notturno et al, 2014 ; Braun et al, 2016 ; Zhang K. et al, 2020 , Zhang K. Y. et al, 2020 ; Cheng et al, 2021 ) were included, of which seven studies ( Kim et al, 2010 ; Yoon et al, 2012 ; Peruzzotti-Jametti et al, 2013 ; Notturno et al, 2014 ; Braun et al, 2016 ; Zhang K. et al, 2020 , Zhang K. Y. et al, 2020 ) were included in the qualitative synthesis ( Figure 1 and Table 1 ). Included studies were published between 2010 and 2021.…”

Section: Resultsmentioning

confidence: 99%

“…Samples sizes in the included studies ranged from 6 to 24. In terms of the species used in each study, seven studies ( Kim et al, 2010 ; Yoon et al, 2012 ; Notturno et al, 2014 ; Braun et al, 2016 ; Zhang K. et al, 2020 , Zhang K. Y. et al, 2020 ; Cheng et al, 2021 ) employed rats, and one study ( Peruzzotti-Jametti et al, 2013 ) used mice ( Table 1 ). Male animals were the most common animal for strokes ( Yoon et al, 2012 ; Peruzzotti-Jametti et al, 2013 ; Notturno et al, 2014 ; Braun et al, 2016 ; Zhang K. et al, 2020 , Zhang K. Y. et al, 2020 ; Cheng et al, 2021 ), while one study ( Kim et al, 2010 ) did not specify the animal sex.…”

Section: Resultsmentioning

confidence: 99%

“…In terms of the species used in each study, seven studies ( Kim et al, 2010 ; Yoon et al, 2012 ; Notturno et al, 2014 ; Braun et al, 2016 ; Zhang K. et al, 2020 , Zhang K. Y. et al, 2020 ; Cheng et al, 2021 ) employed rats, and one study ( Peruzzotti-Jametti et al, 2013 ) used mice ( Table 1 ). Male animals were the most common animal for strokes ( Yoon et al, 2012 ; Peruzzotti-Jametti et al, 2013 ; Notturno et al, 2014 ; Braun et al, 2016 ; Zhang K. et al, 2020 , Zhang K. Y. et al, 2020 ; Cheng et al, 2021 ), while one study ( Kim et al, 2010 ) did not specify the animal sex. Permanent models were induced in two studies ( Kim et al, 2010 ; Notturno et al, 2014 ) and temporary models were induced in six studies ( Yoon et al, 2012 ; Peruzzotti-Jametti et al, 2013 ; Braun et al, 2016 ; Zhang K. et al, 2020 , Zhang K. Y. et al, 2020 ; Cheng et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

“…Male animals were the most common animal for strokes ( Yoon et al, 2012 ; Peruzzotti-Jametti et al, 2013 ; Notturno et al, 2014 ; Braun et al, 2016 ; Zhang K. et al, 2020 , Zhang K. Y. et al, 2020 ; Cheng et al, 2021 ), while one study ( Kim et al, 2010 ) did not specify the animal sex. Permanent models were induced in two studies ( Kim et al, 2010 ; Notturno et al, 2014 ) and temporary models were induced in six studies ( Yoon et al, 2012 ; Peruzzotti-Jametti et al, 2013 ; Braun et al, 2016 ; Zhang K. et al, 2020 , Zhang K. Y. et al, 2020 ; Cheng et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

“…One study ( Yoon et al, 2012 ) used solely anodal tDCS, three studies ( Notturno et al, 2014 ; Zhang K. et al, 2020 , Zhang K. Y. et al, 2020 ) used solely cathodal tDCS, three studies ( Kim et al, 2010 ; Yoon et al, 2012 ; Peruzzotti-Jametti et al, 2013 ) used both types of tDCS as an intervention, and one study ( Cheng et al, 2021 ) used dual tDCS ( Table 1 ). Variations in the stimulation locus, density of current, intervention duration, and timing of intervention were observed.…”

Section: Resultsmentioning

confidence: 99%

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Neuroprotection by Transcranial Direct Current Stimulation in Rodent Models of Focal Ischemic Stroke: A Meta-Analysis

Huang

Zhao²,

Zhao³

et al. 2021

Front. Neurosci.

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Infarct size is associated with stroke severity in clinical studies, so reducing it has become an important target and research hotspot in the treatment of ischemic stroke. Some preclinical studies have shown transcranial direct current stimulation (tDCS) reduced infarct size and improved neurological deficit, but others have not found beneficial effects. Besides, the optimal pattern of tDCS for ischemic stroke remains largely unknown. To shed light on the current circumstance and future research directions, the systematic review evaluated the effect of different tDCS paradigms in reducing infarct size and improving neurological deficit in rodent models of ischemic stroke and assessed the methodological quality of current literature. We searched the MEDLINE (via PubMed), EMBASE, Web of Science, and Scopus from their inception to August 18, 2021, to identify studies evaluating the effects of tDCS in rodent models of ischemic stroke. Eight studies were included, of which seven studies were included in the meta-analysis. The results showed cathodal tDCS, rather than anodal tDCS, reduced infarct size mainly measured by tetrazolium chloride and magnetic resonance imaging (standardized mean difference: −1.13; 95% CI: −1.72, −0.53; p = 0.0002) and improved neurological deficit assessed by a modified neurological severity score (standardized mean difference: −2.10; 95% CI: −3.78, −0.42; p = 0.01) in an early stage of focal ischemic stroke in rodent models. Subgroup analyses showed effects of cathodal tDCS on infarct size were not varied by ischemia duration (ischemia for 1, 1.5, and 2 h or permanent ischemia) and anesthesia (involving isoflurane and ketamine). The overall quality of studies included was low, thus the results must be interpreted cautiously. Published studies suggest that cathodal tDCS may be a promising avenue to explore for augmenting rehabilitation from focal ischemic stroke. Considering the methodological limitations, it is unreliable to blindly extrapolate the animal data to the clinical practice. Future research is needed to investigate the mechanism of tDCS in a randomized and blinded fashion in clinically relevant stroke models, such as elderly animals, female animals, and animals with comorbidities, to find an optimal treatment protocol.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Neuroprotection by Transcranial Direct Current Stimulation in Rodent Models of Focal Ischemic Stroke: A Meta-Analysis

Huang

Zhao²,

Zhao³

et al. 2021

Front. Neurosci.

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Mxene-bpV plays a neuroprotective role in cerebral ischemia-reperfusion injury by activating the Akt and promoting the M2 microglial polarization signaling pathways

Cheng,

Yu,

Zhang

et al. 2024

J Mater Sci: Mater Med

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Studies have shown that the inhibition of phosphatase and tensin homolog deleted on chromosome 10 (PTEN)was neuroprotective against ischemia/reperfusion(I/R) injury. Bisperoxovanadium (bpV), a derivative of vanadate, is a well-established inhibitor of PTEN. However, its function islimited due to its general inadequacy in penetrating cell membranes. Mxene(Ti3C2Tx) is a novel two-dimensional lamellar nanomaterial with an excellent ability to penetrate the cell membrane. Yet, the effects of this nanomaterial on nervous system diseases have yet to be scrutinized. Here, Mxene(Ti3C2Tx) was used for the first time to carry bpV(HOpic), creating a new nanocomposite Mxene-bpV that was probed in a cerebral I/R injury model. The findings showed that this synthetic Mxene-bpV was adequately stable and can cross the cell membraneeasily. We observed that Mxene-bpV treatment significantly increased the survival rate of oxygen glucose deprivation/reperfusion(OGD/R)--insulted neurons, reduced infarct sizes and promoted the recovery of brain function after mice cerebral I/R injury. Crucially, Mxene-bpV treatment was more therapeutically efficient than bpV(HOpic) treatment alone over the same period. Mechanistically, Mxene-bpV inhibited the enzyme activity of PTEN in vitro and in vivo. It also promoted the expression of phospho-Akt (Ser473) by repressing PTEN and then activated the Akt pathway to boost cell survival. Additionally, in PTEN transgenic mice, Mxene-bpV suppressed I/R-induced inflammatory response by promoting M2 microglial polarization through PTEN inhibition. Collectively, the nanosynthetic Mxene-bpV inhibited PTEN’ enzymatic activity by activating Akt pathway and promoting M2 microglial polarization, and finally exerted neuroprotection against cerebral I/R injury. Graphical Abstract

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Transcranial Direct-Current Stimulation Regulates MCT1-PPA-PTEN-LONP1 Signaling to Confer Neuroprotection After Rat Cerebral Ischemia–Reperfusion Injury

Kong

Cui

et al. 2022

Mol Neurobiol

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Propionic acid (PPA) is a critical metabolite involved in microbial fermentation, which functions to reduce fat production, inhibit inflammation, and reduce serum cholesterol levels. The role of PPA in the context of cerebral ischemia–reperfusion (I/R) injury has yet to be clarified. Increasing evidence indicate that transcranial direct-current stimulation (tDCS) is a safe approach that confers neuroprotection in cerebral ischemia injury. Here, we show that the levels of PPA were reduced in the ischemic brain following a rat cerebral I/R injury and in the cultured rat cortical neurons after oxygen–glucose deprivation (OGD), an in vitro model of ischemic injury. We found that the decreased levels of transporter protein monocarboxylate transporter-1 (MCT1) were responsible for the OGD-induced reduction of PPA. Supplementing PPA reduced ischemia-induced neuronal death after I/R. Moreover, our results revealed that the neuroprotective effect of PPA is mediated through downregulation of phosphatase PTEN and subsequent upregulation of Lon protease 1 (LONP1). We demonstrated that direct-current stimulation (DCS) increased MCT1 expression and PPA level in OGD-insulted neurons, while tDCS decreased the brain infarct volume in the MCAO rats via increasing the levels of MCT1 expression and PPA. This study supports a potential application of tDCS in ischemic stroke.

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Transcranial direct-current stimulation protects against cerebral ischemia-reperfusion injury through regulating Cezanne-dependent signaling

Cited by 16 publications

References 41 publications

Neuroprotection by Transcranial Direct Current Stimulation in Rodent Models of Focal Ischemic Stroke: A Meta-Analysis

Neuroprotection by Transcranial Direct Current Stimulation in Rodent Models of Focal Ischemic Stroke: A Meta-Analysis

Mxene-bpV plays a neuroprotective role in cerebral ischemia-reperfusion injury by activating the Akt and promoting the M2 microglial polarization signaling pathways

Transcranial Direct-Current Stimulation Regulates MCT1-PPA-PTEN-LONP1 Signaling to Confer Neuroprotection After Rat Cerebral Ischemia–Reperfusion Injury

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