Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory

Bjekić, Jovana; Čolić, Marija; Živanović, Marko; Milanović, Svetlana; Filipović, Saša R.

doi:10.1016/j.nlm.2018.12.007

Cited by 37 publications

(49 citation statements)

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“…Anode was placed over left lateral PPC (P3 site of the International 10-20 system of EEG electrode placement), a cortical area with high functional and neural connectivity with the hippocampus [33][34][35] , while the return electrode was placed over the contralateral cheek. Our previous studies had shown that tDCS using this montage-PPC and contralateral cheek-produces function-specific effects on AM 13,32 . The constant current anodal tDCS condition followed the standard procedure and parameters-the 1.5 mA constant current was delivered for 20 min, with a gradual ramp-up/down over the first and the last 30 s. Theta otDCS followed the same routine, except that the current was oscillating (± 0.1 mA) around the 1.5 mA in the frequency of average human theta rhythm (5 Hz).…”

Section: Transcranial Direct Current Stimulation (Tdcs)mentioning

confidence: 98%

“…The sample size was a priori calculated using G*Power 3 software 31 for the repeated-measures ANOVA for the power of 0.95 and expected effect size (η 2 ) of 0.15 with correlation across repeated measures of 0.50, based on our previous studies 13,32 . A total of 18 healthy young adults (50% female; age M = 23.78, SD = 1.83; range 21 to 29 years) participated in the study.…”

Section: Participantsmentioning

confidence: 99%

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Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory

Vulić

Bjekić

Paunović

et al. 2021

Sci Rep

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Associative memory (AM) reflects the ability to remember and retrieve multiple pieces of information bound together thus enabling complex episodic experiences. Despite growing interest in the use of transcranial direct current stimulation (tDCS) for the modulation of AM, there are inconsistent evidence regarding its benefits. An alternative to standard constant tDCS could be the application of frequency-modulated tDCS protocols, that mimic natural function-relevant brain rhythms. Here, we show the effects of anodal tDCS oscillating in theta rhythm (5 Hz; 1.5 ± 0.1 mA) versus constant anodal tDCS and sham over left posterior parietal cortex on cued recall of face-word associations. In a crossover design, each participant completed AM assessment immediately following 20-min theta-oscillatory, constant, and sham tDCS, as well as 1 and 5 days after. Theta oscillatory tDCS increased initial AM performance in comparison to sham, and so did constant tDCS. On the group level, no differences between oscillatory and constant tDCS were observed, but individual-level analysis revealed that some participants responded to theta-oscillatory but not to constant tDCS, and vice versa, which could be attributed to their different physiological modes of action. This study shows the potential of oscillatory tDCS protocols for memory enhancement to produce strong and reliable memory-modulating effects which deserve to be investigated further.

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Section: Transcranial Direct Current Stimulation (Tdcs)mentioning

confidence: 98%

Section: Participantsmentioning

confidence: 99%

Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory

Vulić

Bjekić

Paunović

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

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“…Still, the studies that used recall tasks and longer duration of stimulation showed enhancing effects of anodal tDCS 30 . Further, TDCS studies that have targeted posterior brain regions show promise for modulating both item 31–33 and associative memory 34–36 .…”

Section: Introductionmentioning

confidence: 99%

Theta band high definition transcranial alternating current stimulation, but not transcranial direct current stimulation, improves associative memory performance

Lang

Gan

Alrazi

et al. 2019

Sci Rep

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Associative memory (AM) deficits are common in neurodegenerative disease and novel therapies aimed at improving these faculties are needed. Theta band oscillations within AM networks have been shown to be important for successful memory encoding and modulating these rhythms represents a promising strategy for cognitive enhancement. Transcranial alternating current stimulation (TACS) has been hypothesized to entrain and increase power of endogenous brain rhythms. For this reason, we hypothesized that focal delivery of theta band electrical current, using high-definition TACS, would result in improved AM performance compared to sham stimulation or transcranial direct current stimulation (TDCS). In this pilot study, 60 healthy subjects were randomized to receive high definition TACS, high definition TDCS, or sham stimulation delivered to the right fusiform cortex during encoding of visual associations. Consistent with our hypothesis, improved AM performance was observed in the TACS group, while TDCS had no effect. However, TACS also resulted in improved correct rejection of never seen items, reduced false memory, and reduced forgetting, suggesting the effect may not be specific for AM processes. Overall, this work informs strategies for improving associative memory and suggests alternating current is more effective than direct current stimulation in some contexts.

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“…Some of the previous findings reported lack of positive effects of single session anodal tDCS over P4 on working memory (Berryhill, Wencil, Coslett, & Olson, 2010). On the other hand, there is evidence (Bjekić, Čolić, Živanović, Milanović, & Filipović, 2019) for memory performance enhancement by tDCS application over P4. Within this empirical background, our results remain unclear for now; there is certainly a need to reconsider our spatial memory measures and possible different electrode montage in further studies.…”

Section: Discussionmentioning

confidence: 90%

Preliminary findings of single session of noninvansive brain stimulation over parietal lobe and performance on spatial memory task

Čolić

Konstantinović

Bjekić

et al. 2019

Preprint

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Spatial memory relies on efficient encoding, storage and retrieval of spatial information, which enables us to remember paths or locations of objects in everyday life. Moreover, this type of memory has been shown to decline with age and various neurodegenerative disorders. Parietal cortex has been shown to play an important role in the formation of short-term representations of spatial information. The aim of the current study was to test the possibility of immediate and long-term spatial memory enhancement, by increasing excitability of parietal posterior cortex. We used transcranial direct current stimulation (tDCS) over posterior parietal cortex in a placebo-controlled cross-over study. Participants received anodal (1.5 mA) or sham tDCS stimulation over P4 site (10-20 EEG system) for 20 minutes in two separate sessions. Immediately after stimulation, participants completed a spatial maze task, which consisted of learning block, 2D recall, and 3D recall. Spatial memory performance was tested 24 hours and 7 days after stimulation, to assess potential long-term effects. We found no significant effects of anodal stimulation on spatial memory performance either on immediate or delayed recall. This was the case with both, 2D and 3D spatial memory recall. Our results are in line with some studies that suggest that single brain stimulation sessions do not always produce effects on cognitive functions.

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Transcranial direct current stimulation (tDCS) over parietal cortex improves associative memory

Cited by 37 publications

References 38 publications

Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory

Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory

Theta band high definition transcranial alternating current stimulation, but not transcranial direct current stimulation, improves associative memory performance

Preliminary findings of single session of noninvansive brain stimulation over parietal lobe and performance on spatial memory task

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