Transcranial Low Voltage Pulsed Electromagnetic Fields in Patients with Treatment-Resistant Depression

Martiny, Klaus; Lunde, Marianne; Bech, Per

doi:10.1016/j.biopsych.2010.02.017

Cited by 119 publications

(130 citation statements)

References 21 publications

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“…is no. However, the rate of remission in the group of patients receiving one daily dose was much higher (73%) than the expected rate of 25% that was based on our results from our first T-PEMF study (4), which was completed after 5 weeks of therapy. A major outcome of our present study is therefore that the extension of the trial from 5 to 8 weeks has doubled the remission rate.…”

Section: Discussionmentioning

confidence: 66%

Dose-remission of pulsating electromagnetic fields as augmentation in therapy-resistant depression: a randomized, double-blind controlled study

Straasø

Lauritzen

Lunde

et al. 2014

Acta Neuropsychiatr.

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Section: Discussionmentioning

confidence: 66%

Dose-remission of pulsating electromagnetic fields as augmentation in therapy-resistant depression: a randomized, double-blind controlled study

Straasø

Lauritzen

Lunde

et al. 2014

Acta Neuropsychiatr.

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“…The last observation carried forward (LOCF) approach was applied in all 3 studies. Concerning study C, our results reported here are from a larger study [22] in which another method was used. Summary statistics have been presented as means (standard deviation for continuous variables) or percentages.…”

Section: Outcome Statisticsmentioning

confidence: 79%

Identifying Patients with Therapy-Resistant Depression by using Factor Analysis

Andreasson

Liest²,

Lunde³

et al. 2010

Pharmacopsychiatry

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“…Classical transcranial magnetic stimulation (TMS) or repetitive TMS (rTMS) delivers focal high intensity stimulation (peak magnetic field of 1–2 T, generating electric fields, E ≥100 V/m) to depolarise underlying neurons and modulate specific neural circuits. Newer low- or pulsed-field magnetic stimulation (LFMS, PMF) delivers diffuse low-intensity stimuli (μT-mT range, E ≤ 1 V/m) that are also biologically effective: modifying cortical function (Capone et al, 2009; Robertson et al, 2010), brain oscillations (Cook et al, 2004; Modolo et al, 2013) and metabolism (Volkow et al, 2010), as well as neurological dysfunction (Martiny et al, 2010; Rohan et al, 2014). We have combined these two approaches creating a small rodent coil to deliver focal low-intensity magnetic stimulation (LI-rTMS), and found that 2 weeks of LI-rTMS can reorganize neural circuits (Rodger et al, 2012; Makowiecki et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

In vitro Magnetic Stimulation: A Simple Stimulation Device to Deliver Defined Low Intensity Electromagnetic Fields

Grehl

Martina

Goyenvalle

et al. 2016

Front. Neural Circuits

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Non-invasive brain stimulation (NIBS) by electromagnetic fields appears to benefit human neurological and psychiatric conditions, although the optimal stimulation parameters and underlying mechanisms remain unclear. Although, in vitro studies have begun to elucidate cellular mechanisms, stimulation is delivered by a range of coils (from commercially available human stimulation coils to laboratory-built circuits) so that the electromagnetic fields induced within the tissue to produce the reported effects are ill-defined. Here, we develop a simple in vitro stimulation device with plug-and-play features that allow delivery of a range of stimulation parameters. We chose to test low intensity repetitive magnetic stimulation (LI-rMS) delivered at three frequencies to hindbrain explant cultures containing the olivocerebellar pathway. We used computational modeling to define the parameters of a stimulation circuit and coil that deliver a unidirectional homogeneous magnetic field of known intensity and direction, and therefore a predictable electric field, to the target. We built the coil to be compatible with culture requirements: stimulation within an incubator; a flat surface allowing consistent position and magnetic field direction; location outside the culture plate to maintain sterility and no heating or vibration. Measurements at the explant confirmed the induced magnetic field was homogenous and matched the simulation results. To validate our system we investigated biological effects following LI-rMS at 1 Hz, 10 Hz and biomimetic high frequency, which we have previously shown induces neural circuit reorganization. We found that gene expression was modified by LI-rMS in a frequency-related manner. Four hours after a single 10-min stimulation session, the number of c-fos positive cells increased, indicating that our stimulation activated the tissue. Also, after 14 days of LI-rMS, the expression of genes normally present in the tissue was differentially modified according to the stimulation delivered. Thus we describe a simple magnetic stimulation device that delivers defined stimulation parameters to different neural systems in vitro. Such devices are essential to further understanding of the fundamental effects of magnetic stimulation on biological tissue and optimize therapeutic application of human NIBS.

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Transcranial Low Voltage Pulsed Electromagnetic Fields in Patients with Treatment-Resistant Depression

Cited by 119 publications

References 21 publications

Dose-remission of pulsating electromagnetic fields as augmentation in therapy-resistant depression: a randomized, double-blind controlled study

Dose-remission of pulsating electromagnetic fields as augmentation in therapy-resistant depression: a randomized, double-blind controlled study

Identifying Patients with Therapy-Resistant Depression by using Factor Analysis

In vitro Magnetic Stimulation: A Simple Stimulation Device to Deliver Defined Low Intensity Electromagnetic Fields

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