Transcranial Magnetic Stimulation in Disorders of Consciousness: An Update and Perspectives

Huang, Weilong; Chen, Qiang; Li, Jun; Liu, Lin; Tang, Jiaxi; Zou, Mingang; Zeng, Tianxiang; Li, Huichen; Jiang, Qing; Jiang, QiuHua

doi:10.14336/ad.2022.1114

Cited by 5 publications

(4 citation statements)

References 114 publications

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“…As early as 2009, Louise-Bender Pape et al (2009) found that DOC patients tended to show significant neurobehavioral improvements that were temporally associated with the delivery of rTMS. Recently, Huang et al (2023) reported the efficacy and possible mechanisms of rTMS for DOC and discussed the potential key parameters that affected the therapeutic efficiency of rTMS in DOC patients. Additionally, iTBS was a novel rTMS model that may be suggested as a potential therapeutic intervention of DOC ( Wu et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Research hotspots and frontiers of neuromodulation techniques in disorders of consciousness: a bibliometric analysis

Guo,

Han,

et al. 2024

Front. Neurosci.

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BackgroundThe characteristics of disorders of consciousness (DOC) are changes in arousal and/or awareness caused by severe brain injuries. To date, the management of DOC patients remains a complex and challenging task, and neuromodulation techniques offer a promising solution. However, a bibliometric analysis focusing on neuromodulation techniques in DOC is currently absent. The aim of this study is to provide a bibliometric visualization analysis to investigate the research hotspots and frontiers in the field of neuromodulation techniques in DOC from 2012 to 2022.MethodsThe publications were collected and retrieved from the Web of Science (WoS) from 2012 to 2022. CiteSpace and Microsoft Excel were utilized perform the first global bibliographic analysis of the literature related to neuromodulation techniques for DOC.ResultsThe analysis included a total of 338 publications. From 2012 to 2022, a consistent yet irregular increase in the number of articles published on neuromodulation techniques in DOC was observed. Frontiers in Neurology published the highest number of papers (n = 16). Neurosciences represented the main research hotspot category (n = 170). The most prolific country, institution, and author were the USA (n = 105), the University of Liege (n = 41), and Laureys Steven (n = 38), respectively. An analysis of keywords revealed that UWS/VS, MCS, and TMS constituted the primary research trends and focal points within this domain.ConclusionThis bibliometric study sheds light on the current progress and emerging trends of neuromodulation techniques in DOC from 2012 to 2022. The focal topics in this domain encompass the precise diagnosis of consciousness levels in patients suffering from DOC and the pursuit of efficacious neuromodulation-based evaluation and treatment protocols for such patients.

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Section: Discussionmentioning

confidence: 99%

Research hotspots and frontiers of neuromodulation techniques in disorders of consciousness: a bibliometric analysis

Guo,

Han,

et al. 2024

Front. Neurosci.

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“…Neuroscientists are investigating ways to accelerate the improvement of consciousness in DOC patients while promoting functional recovery. Neuromodulation therapy has shown beneficial effects in promoting recovery after traumatic brain injury, but existing treatments such as transcranial magnetic stimulation, deep brain stimulation (DBS) and hyperbaric oxygen therapy still need further systematic studies to demonstrate their mechanisms of action ( Rezaei Haddad et al, 2019 ; Chen et al, 2022 ; Huang et al, 2023 ). The brain function is mediated by the interaction between different neural circuits and neurons in brain regions.…”

Section: Introductionmentioning

confidence: 99%

Current status and prospect of transcutaneous auricular vagus nerve stimulation for disorders of consciousness

Wang,

Zhang,

Zhai

et al. 2024

Front. Neurosci.

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Disordered Consciousness (DOC) is among neurological disorders for which there is currently no admitted treatment. The pathogenesis of DOC is still unclear, covering a variety of indistinguishable types of diseases, high misdiagnosis rate and poor prognosis. Most treatments remain to be clarified in the future to provide adequate evidence for clinical guidance. Neuromodulation technology aims to regulate neural circuits to promote awakening more directly. At present, it is confirmed that the potential of transcutaneous auricular vagus nerve stimulation (taVNS) as a therapeutic tool is worth exploring in the context of consciousness disorders, as previously proposed for invasive forms of VNS, in which the means of stimulating the vagus nerve to change the brain areas related to cosciousness have also received widespread attention. In this paper, we review the literature on taVNS and DOC to better understand the current status and development prospect of taVNS treament as a non-invasive neuromodulation method with sensitivity and/or specificity at the single subject.

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“… 14 Repeated transcranial magnetic stimulation has been explored in treatment of vs and MCS, but its clinical efficacy is still controversial and awaits confirmation through high-quality intervention studies. 15 16 In addition, it is still unclear whether benefits of invasive brain stimulation outweigh its risks in the treatment of DoC. 17–19 Therefore, novel and more effective therapeutic interventions for pDoC are needed.…”

Section: Introductionmentioning

confidence: 99%

Transcutaneous auricular vagal nerve stimulation for consciousness recovery in patients with prolonged disorders of consciousness (TAVREC): study protocol for a multicenter, triple-blind, randomized controlled trial in China

Zhou,

Peng,

Liu

et al. 2024

BMJ Open

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IntroductionProlonged disorders of consciousness (pDoC) are a catastrophic condition following brain injury with few therapeutic options. Transcutaneous auricular vagal nerve stimulation (taVNS), a safe, non-invasive intervention modulating thalamo-cortical connectivity and brain function, is a possible treatment option of pDoC. We developed a protocol for a randomised controlled study to evaluate the effectiveness of taVNS on consciousness recovery in patients with pDoC (TAVREC).Methods and analysisThe TAVREC programme is a multicentre, triple-blind, randomised controlled trial with 4 weeks intervention followed by 4 weeks follow-up period. A minimum number of 116 eligible pDoC patients will be recruited and randomly receive either: (1) conventional therapy plus taVNS (30 s monophasic square current of pulse width 300 μs, frequency of 25 Hz and intensity of 1 mA followed by 30 s rest, 60 min, two times per day, for 4 weeks); or (2) conventional therapy plus taVNS placebo. Primary outcome of TAVREC is the rate of improved consciousness level based on the Coma Recovery Scale-Revised (CRS-R) at week 4. Secondary outcomes are CRS-R total and subscale scores, Glasgow Coma Scale score, Full Outline of UnResponsiveness score, ECG parameters, brainstem auditory evoked potential, upper somatosensory evoked potential, neuroimaging parameters from positron emission tomography/functional MRI, serum biomarkers associated with consciousness level and adverse events.Ethics and disseminationThis study was reviewed and approved by the Research Ethics Committee of the First Affiliated Hospital of Nanjing Medical University (Reference number: 2023-SR-392). Findings will be disseminated in a peer-reviewed journal and presented at relevant conferences.Trial registration numberChiCTR2300073950.

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Transcranial Magnetic Stimulation in Disorders of Consciousness: An Update and Perspectives

Cited by 5 publications

References 114 publications

Research hotspots and frontiers of neuromodulation techniques in disorders of consciousness: a bibliometric analysis

Research hotspots and frontiers of neuromodulation techniques in disorders of consciousness: a bibliometric analysis

Current status and prospect of transcutaneous auricular vagus nerve stimulation for disorders of consciousness

Transcutaneous auricular vagal nerve stimulation for consciousness recovery in patients with prolonged disorders of consciousness (TAVREC): study protocol for a multicenter, triple-blind, randomized controlled trial in China

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