Transcranial pulse current stimulation improves the locomotor function in a rat model of stroke

Wang, Wenjing; Zhong, Yanbiao; Zhao, Jingjun; Ren, Meng; Sicong, Zhang; Xu, Ming; Xu, Shutian; Zhang, Yingjie; Shan, Chunlei

doi:10.4103/1673-5374.301018

Cited by 13 publications

(9 citation statements)

References 32 publications

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“…The findings of a study revealed that tPCS, similar to other tES techniques, significantly influenced motor disorders in collagenase‐induced intracerebral hemorrhage (Heidarzadegan et al., 2022). Another study suggested that tPCS can enhance the locomotor function of stroke rats by regulating the expression of microtubule‐associated protein around the ischemic penumbra (Wang et al., 2021). Finally, a study examined whether the appropriate current intensity of a‐tPCS‐induced cortical excitability was associated with calcium elevation in astrocytes, which regulate synaptic transmission (Ma et al., 2019).…”

Section: Resultsmentioning

confidence: 99%

“…All these studies recruited both male and female participants, except one, which only recruited females with fibromyalgia (Castro et al., 2021). Furthermore, the sample size in the included animal studies ranged from 35 to 56 male rats aged 8 to 12 weeks (Heidarzadegan et al., 2022; Ma et al., 2019; Wang et al., 2021).…”

Section: Resultsmentioning

confidence: 99%

“…Also, another study that investigated the effects of different stimulation times on the EEG power band and coherency employed 30 min tPCS (Vasquez et al., 2016). Additionally, in animal studies, the amplitude of direct cellular stimulation has typically been set at 0.2 mA for 20 min at frequencies of both 10 Hz (Wang et al., 2021) and 30 Hz (Heidarzadegan et al., 2022). However, in another animal study, a 2 Hz frequency of tPCS was employed with amplitudes ranging from 0.1 to 0.35 mA, administered for 2 s and 5 min (Ma et al., 2019).…”

Section: Resultsmentioning

confidence: 99%

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Transcranial pulsed current stimulation: A scoping review of the current literature on scope, nature, underlying mechanisms, and gaps

Malekahmad,

Frazer,

Zoghi

et al. 2024

Psychophysiology

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Transcranial pulsed current stimulation (tPCS) is a noninvasive brain stimulation technique that has aroused considerable attention in recent years. This review aims to provide an overview of the existing literature on tPCS, examine the scope and nature of previous research, investigate its underlying mechanisms, and identify gaps in the literature. Searching online databases resulted in 36 published tPCS studies from inception until May 2023. These studies were categorized into three groups: human studies on healthy individuals, human studies on clinical conditions, and animal studies. The findings suggest that tPCS has the potential to modulate brain excitability by entraining neural oscillations and utilizing stochastic resonance. However, the underlying mechanisms of tPCS are not yet fully understood and require further investigation. Furthermore, the included studies indicate that tPCS may have therapeutic potential for neurological diseases. However, before tPCS can be applied in clinical settings, a better understanding of its mechanisms is crucial. Hence, the tPCS studies were categorized into four types of research: basic, strategic, applied, and experimental research, to identify the nature of the literature and gaps. Analysis of these categories revealed that tPCS, with its diverse parameters, effects, and mechanisms, presents a wide range of research opportunities for future investigations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Transcranial pulsed current stimulation: A scoping review of the current literature on scope, nature, underlying mechanisms, and gaps

Malekahmad,

Frazer,

Zoghi

et al. 2024

Psychophysiology

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“…B. wachstumshemmende Proteine blockieren, zielgerichtete nichtcodierende RNAs, lokale oder themenbezogene Anwendung von Biomaterialien wie Hydrogelen oder lebenden Gerüsten (für eine Übersicht siehe [2,6]). Neben Behandlungen, bei denen Substanzen oder Moleküle direkt auf der Transkriptions-oder Translationsebene von Regenerationswegen eingreifen, zielen andere therapeutische Strategien auf eine verbesserte Hirnreparatur durch klassische neuro-rehabilitative Trainingsparadigmen, Methoden einer angereicherten Umgebung, neuartige Ansätze wie Gehirn-Computer-Schnittstellen, den Einsatz künstlicher Intelligenz sowie Methoden nicht-invasiver Hirnstimulationen [6,7]. Darüber hinaus erlangen robotische Geräte, die ein wiederholtes und intensives Training ermöglichen, zunehmende Bedeutung, da sie die motorische Leistung nach einem Schlaganfall verbessern und neuroplastische Veränderungen auslösen.…”

Section: Hintergrundunclassified

Therapien zur Verbesserung der Schlaganfall-Regeneration – Ergebnisse klinischer Studien im wissenschaftlichen Kontext

Rogalewski,

Schäbitz

2023

Fortschr Neurol Psychiatr

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ZusammenfassungZu den Erholungsprozessen nach einem Schlaganfall gehören die Wiederherstellung oder Kompensation von Funktionen, die ursprünglich verloren gingen oder nach einer Verletzung neu erworben wurden. Therapeutische Eingriffe können diese Prozesse entweder direkt verbessern oder Prozesse hemmen, die die Regeneration behindern. Zahlreiche experimentelle Studien ließen auf eine große Chance für solche Behandlungen hoffen, doch die Ergebnisse der jüngsten großen klinischen Studien mit Neuromodulatoren wie Dopamin und Fluoxetin waren leider enttäuschend. Die Gründe dafür sind vielfältig und betreffen die Übertragung der Ergebnisse aus Tiermodellen auf den Menschen. Diese Translationsblockade wird durch Unterschiede zwischen Tier und Mensch in Bezug auf den genetischen und epigenetischen Hintergrund, die Größe und Anatomie des Gehirns, die zerebrale Gefäßanatomie, das Immunsystem sowie die klinische Funktion und das Verhalten definiert. Zu den Rückwärtsblockaden gehört die inkompatible Anpassung von Zielen und Ergebnissen in klinischen Studien im Hinblick auf frühere präklinische Erkenntnisse. So variiert beispielsweise das Design der klinischen Regenerationsstudien stark und war durch die Auswahl unterschiedlicher klinischer Endpunkte, die Einbeziehung eines breiten Spektrums von Schlaganfall-Subtypen und klinischen Syndromen sowie durch unterschiedliche Zeitfenster für den Behandlungsbeginn nach Infarktbeginn gekennzeichnet. Die vorliegende Übersichtsarbeit diskutiert diese Aspekte anhand der Ergebnisse der letzten Schlaganfall-Regenerationsstudien mit dem Ziel, einen Beitrag zur Entwicklung einer Therapie zu leisten, die das funktionelle Ergebnis eines chronischen Schlaganfallpatienten verbessert.

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“…Rodent motor cortex plays an important role in motor control (Peters et al, 2017;Bundy et al, 2019;Veuthey et al, 2020). If the motor cortex injury could be treated in time, motor function may be recovery gradually (Wang et al, 2021). These injuries are related to oxidative stress (Chamorro et al, 2016), excitotoxicity (Lai et al, 2014), and neuroinflammation (Jayaraj et al, 2019) induced by reperfusion.…”

Section: Introductionmentioning

confidence: 99%

Cerebral Ischemia-Reperfusion Is Associated With Upregulation of Cofilin-1 in the Motor Cortex

Yin

Cheng

et al. 2021

Front. Cell Dev. Biol.

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Cerebral ischemia is one of the leading causes of death. Reperfusion is a critical stage after thrombolysis or thrombectomy, accompanied by oxidative stress, excitotoxicity, neuroinflammation, and defects in synapse structure. The process is closely related to the dephosphorylation of actin-binding proteins (e.g., cofilin-1) by specific phosphatases. Although studies of the molecular mechanisms of the actin cytoskeleton have been ongoing for decades, limited studies have directly investigated reperfusion-induced reorganization of actin-binding protein, and little is known about the gene expression of actin-binding proteins. The exact mechanism is still uncertain. The motor cortex is very important to save nerve function; therefore, we chose the penumbra to study the relationship between cerebral ischemia-reperfusion and actin-binding protein. After transient middle cerebral artery occlusion (MCAO) and reperfusion, we confirmed reperfusion and motor function deficit by cerebral blood flow and gait analysis. PCR was used to screen the high expression mRNAs in penumbra of the motor cortex. The high expression of cofilin in this region was confirmed by immunohistochemistry (IHC) and Western blot (WB). The change in cofilin-1 expression appears at the same time as gait imbalance, especially maximum variation and left front swing. It is suggested that cofilin-1 may partially affect motor cortex function. This result provides a potential mechanism for understanding cerebral ischemia-reperfusion.

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Transcranial pulse current stimulation improves the locomotor function in a rat model of stroke

Cited by 13 publications

References 32 publications

Transcranial pulsed current stimulation: A scoping review of the current literature on scope, nature, underlying mechanisms, and gaps

Transcranial pulsed current stimulation: A scoping review of the current literature on scope, nature, underlying mechanisms, and gaps

Therapien zur Verbesserung der Schlaganfall-Regeneration – Ergebnisse klinischer Studien im wissenschaftlichen Kontext

Cerebral Ischemia-Reperfusion Is Associated With Upregulation of Cofilin-1 in the Motor Cortex

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