Transcription factor 21 gene polymorphism in patients with coronary artery disease

Hamed, Waleed Abdou Ibrahim; Hammouda, Ghada E; El-Hefnawy, Sally M; El-Gayed, Eman M Abd

doi:10.2147/rrcc.s121617

Cited by 4 publications

(6 citation statements)

References 22 publications

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“…The present study shows that TCF21 gene G/C polymorphism is significantly associated with stable angina and STEMI both in non-adjusted and adjusted models (Table 3). In agreement with our results, Wang et al [45], Hamed et al [22] and Schunkert et al [35] reported significant associations between TCF21 rs12190287 with CAD. Furthermore, Santos et al also demonstrated that TCF21 rs12190287 may be a risk factor for major adverse cardiovascular events, and suggested that the TCF21 gene may affect fundamental smooth muscle cell processes in response to vascular stress, thereby facilitating the progression of atherosclerosis [37].…”

Section: Discussionsupporting

confidence: 93%

“…In the present study, we showed that T2DM, hypertension, and hyperlipidemia status were significantly associated with genotypes of TCF21 are consistent with previous studies [22,24]. Fujimaki et al showed that after adjusting for age, sex, BMI and smoking status in multivariable logistic regression analysis, TCF21 rs12190287 was significantly correlated with hypertension (OR 1.21, p=0.0014), and that the C allele was a risk factor for hypertension [24].…”

Section: Discussionsupporting

confidence: 91%

“…A previous study reported a significant association between the TCF21 gene G/C polymorphism with CAD in an Egypt population [22]. Santos et al reported that the TCF21 polymorphism was a risk factor for CAD events in a Portuguese population [37].…”

Section: Discussionmentioning

confidence: 97%

“…In humans of various ethnicity, a higher risk of CAD has been associated with rs12190287, a single nucleotide polymorphism (SNP) located in the 3′untranslated region of TCF21 [19][20][21]. Hamed et al indicated that the CC genotype and C allele of TCF21 (12190287G/C) polymorphisms may be genetic risk factors for CAD [22]. Furthermore, in a Chinese population, the TCF21 rs12190287 polymorphism was also shown to confer susceptibility to ventricular septal defects [23].…”

Section: Introductionmentioning

confidence: 99%

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Transcription factor 21 rs12190287 polymorphism is related to stable angina and ST elevation myocardial infarction in a Chinese Population

Yu,

Lee,

Tsai

et al. 2024

Int. J. Med. Sci.

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Background: Transcription factor 21 (TCF21, epicardin, capsuling, pod-1) is expressed in the epicardium and is involved in the regulation of cell fate and differentiation via epithelial-mesenchymal transformation during development of the heart. In addition, TCF21 can suppress the differentiation of epicardial cells into vascular smooth muscle cells and promote cardiac fibroblast development. This study aimed to explore whether TCF21 gene (12190287G/C) variants affect coronary artery disease risk. Methods: We enrolled 381 patients who had stable angina, 138 with ST elevation myocardial infarction (STEMI), and 276 healthy subjects. Genotyping of rs12190287 of the TCF21 gene was performed. Results: Higher frequencies of the CC genotype were found in the patients with stable angina/STEMI than in the healthy controls. After adjusting for diabetes mellitus, hypertension, age, sex, smoking, body mass index and hyperlipidemia, the patients with the CC genotype of the TCF21 gene were associated with 2.49-and 9.19-fold increased risks of stable angina and STEMI, respectively, compared to the patients with the GG genotype. Furthermore, TCF21 CC genotypes showed positive correlations with both stable angina and STEMI, whereas TCF21 GG genotypes exhibited a negative correlation with STEMI. Moreover, the stable angina and STEMI patients with the CC genotype had significantly elevated high-sensitivity C-reactive protein levels than those with the GG genotype. In addition, significant associations were found between type 2 diabetes mellitus, hypertension, and hyperlipidemia with TCF21 gene polymorphisms (p for trend < 0.05). Conclusion: TCF21 gene polymorphisms may increase susceptibility to stable angina and STEMI.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Transcription factor 21 rs12190287 polymorphism is related to stable angina and ST elevation myocardial infarction in a Chinese Population

Yu,

Lee,

Tsai

et al. 2024

Int. J. Med. Sci.

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“…Transcription factors (TFs) play important role in regulation of transcription by binding to cis regulatory regions in the vicinity of the regulated genes (Hobert 2008). Notably, polymorphism in TFs have recently been associated with several diseases including hypertension, coronary artery disease, Type 2 diabetes mellitus and lipedema (Fujimaki et al 2015;Hamed et al 2016;Palizban et al 2017). Here, we hypothesize that polymorphism within transcription factors may be associated with the transcription levels of their transcribed genes.…”

Section: Introductionmentioning

confidence: 97%

TF-TWAS: Transcription-factor polymorphism associated with tissue-specific gene expression

Tang

Gottlieb

2018

Preprint

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Transcriptional regulation is associated with a broad range of diseases. Methods associating genetic polymorphism with gene transcription levels offer key insights for understanding the transcriptional regulation plan. The majority of gene imputation methods focus on modeling polymorphism in the cis regions of the gene, partially owing to the large genetic search space.We hypothesize that polymorphism within transcription factors (TFs) may help explain transcription levels of their transcribed genes.Here, we test this hypothesis by developing TF-TWAS: imputation models that integrate transcription factor information with transcription-wide association study methodology. By comparing TF-TWAS models to base models that use only gene cis information, we are able to estimate possible mechanisms of the TF polymorphism effect -TF expression or binding affinity within four tissueswhole blood, liver, brain hippocampus and coronary artery.We identified 48 genes where the TF-TWAS models explain significantly better their expression than cis models alone in at least one of the four tissues. Sixteen of these genes are associated with various diseases, including cancer, neurological, psychiatric and rare genetic diseases. Our method is a new expansion to transcriptome-wide association studies and enables the identification of new associations between polymorphism in transcription factor and gene transcription levels.

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The association between TCF21 rs12190287 polymorphism and cardiovascular diseases risk: The first meta-analysis

Uddin

Aziz²,

Mostaid³

et al. 2022

Human Gene

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Transcription factor 21 gene polymorphism in patients with coronary artery disease

Cited by 4 publications

References 22 publications

Transcription factor 21 rs12190287 polymorphism is related to stable angina and ST elevation myocardial infarction in a Chinese Population

Transcription factor 21 rs12190287 polymorphism is related to stable angina and ST elevation myocardial infarction in a Chinese Population

TF-TWAS: Transcription-factor polymorphism associated with tissue-specific gene expression

The association between TCF21 rs12190287 polymorphism and cardiovascular diseases risk: The first meta-analysis

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