Transcription factor AP-2α activates RNA polymerase III–directed transcription and tumor cell proliferation by controlling expression of c-MYC and p53

Wang, Juan; Chen, Qi‐Yue; Peng, Feixia; Zhao, Shasha; Zhang, Cheng; Song, Xiaoye; Yu, Deen; Wu, Zhenpeng; Du, Jiannan; Ni, Hongwei; Deng, Huan; Deng, Wensheng

doi:10.1016/j.jbc.2023.102945

Cited by 2 publications

(2 citation statements)

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“…Collectively, tumor proliferation occurs in non-small cell lung cancer (NSCLC) [ 16 ]. Indirectly, TFAP2A can activate the target genes of RNA polymerase III (Pol III) by transcriptionally upregulating Pol III subunits, such as BRF1 and GTF3C2 [ 17 ].…”

Section: Regulatory Modes Of Tfap2 On Downstream Targetsmentioning

confidence: 99%

“…Conversely, TP53 can help to loosen the chromatin structure of the regulatory region of the TFAP2A and TFAP2C promoters to increase chromatin accessibility that facilitates TP53 binding to their promoters to induce their expression and thus ultimately inhibit tumor proliferation. In addition, TFAP2A indirectly inhibits TP53 expression by upregulating the expression of MDM2, an upstream suppressor of TP53 [ 17 ].…”

Section: The Functions Of Tfap2 In Different Aspects Of Tumor Biologymentioning

confidence: 99%

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Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

et al. 2023

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The transcription factor family activator protein 2 (TFAP2) is vital for regulating both embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding proteins, including TFAP2A, TFAP2B, TFAP2C, TFAP2D and TFAP2E. The importance of TFAP2 in tumor biology is becoming more widely recognized. While TFAP2D is not well studied, here, we mainly focus on the other four TFAP2 members. As a transcription factor, TFAP2 regulates the downstream targets directly by binding to their regulatory region. In addition, the regulation of downstream targets by epigenetic modification, posttranslational regulation, and interaction with noncoding RNA have also been identified. According to the pathways in which the downstream targets are involved in, the regulatory effects of TFAP2 on tumorigenesis are generally summarized as follows: stemness and EMT, interaction between TFAP2 and tumor microenvironment, cell cycle and DNA damage repair, ER- and ERBB2-related signaling pathway, ferroptosis and therapeutic response. Moreover, the factors that affect TFAP2 expression in oncogenesis are also summarized. Here, we review and discuss the most recent studies on TFAP2 and its effects on carcinogenesis and regulatory mechanisms.

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Section: Regulatory Modes Of Tfap2 On Downstream Targetsmentioning

confidence: 99%

Section: The Functions Of Tfap2 In Different Aspects Of Tumor Biologymentioning

confidence: 99%

Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

et al. 2023

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miR-1293 suppresses osteosarcoma progression by modulating drug sensitivity in response to cisplatin treatment

Wang,

Huang,

Chen

et al. 2024

International Immunopharmacology

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Transcription factor AP-2α activates RNA polymerase III–directed transcription and tumor cell proliferation by controlling expression of c-MYC and p53

Cited by 2 publications

References 53 publications

Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

miR-1293 suppresses osteosarcoma progression by modulating drug sensitivity in response to cisplatin treatment

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