2019
DOI: 10.4049/jimmunol.202.supp.185.8
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Transcription factor Blimp-1 regulates sebocyte homeostasis and cytokine production

Abstract: Blimp-1, encoded by Prdm1, is a master transcriptional factor that governs the differentiation fate of many cell types, including epidermal keratinocytes. Previous results from our laboratory showed that inducible deletion of Prdm1 in mouse epidermis spontaneously induces skin inflammation. Epidermis composes of not only epidermal keratinocytes, but also epidermal appendages, including hair follicles, sebaceous glands and sweat glands. Sebaceous glands release the “oil” contents that lubricate the skin. Our pr… Show more

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