2023
DOI: 10.1177/17448069231152125
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Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons

Abstract: Nerve injury can induce aberrant changes in ion channels, enzymes, and cytokines/chemokines in the dorsal root ganglia (DRGs); these changes are due to or at least partly governed by transcription factors that contribute to the genesis of neuropathic pain. However, the involvement of transcription factors in neuropathic pain is poorly understood. In this study, we report that transcription factor (TF) ETS proto-oncogene 1 (ETS1) is required for the initiation and development of neuropathic pain. Sciatic nerve … Show more

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Cited by 5 publications
(2 citation statements)
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“…This table provides an overview of the pharmacological modulation possibilities of the epigenetic machinery; thus, it can pave the way for the development of novel epigenetic drugs that target neuropathic pain. Baicalin SNL [51] Sodium butyrate CCI [52] LG325 SNI [54] Zingiberene SNI [56] SAHA SNI/Trigeminal inflammatory compression/SNL/PSNL/CCI/Bone cancer [28,45,47,57,66,70,71,76,79,86] Carbamazepine Trigeminal neuralgia [67] CAY10683 SNL [72] Trichostatin A PSNL/Bone cancer/CCI [76,[82][83][84][85] Valproic acid PSNL [76,84] JNJ26481585 (quinostat) Chemotrerapy-induced neuropathy [129] Bromodomain and extraterminal (BET) i-BET762 SNI [57] JQ1 Spinal cord injury [98] Histone deacetylase-bromodomain-containing proteins (HDAC/BRD) SUM52 SNI [58] SUM35 SNI [58] Silent information regulator (SIRT) Resveratrol (activator) Bortezomib-induced neuropathy [62] SRT1720 (activator) Bortezomib-induced neuropathy/CCI [62,64] Histone acetyltransferase (HAT) Anacardic acid PSNL [88,89] Histone methyltranserase G9a UNC0638 SNL [45,113] BIX01294 SNL [112] Enhancer of the histone methyltransferase zeste homolog-2 (EZH2) GSK503 SNL [45] Lysine demethylase 7A (KDM7A) NCDM-64 Chemotherapy-induced neuropathy [116] Author…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This table provides an overview of the pharmacological modulation possibilities of the epigenetic machinery; thus, it can pave the way for the development of novel epigenetic drugs that target neuropathic pain. Baicalin SNL [51] Sodium butyrate CCI [52] LG325 SNI [54] Zingiberene SNI [56] SAHA SNI/Trigeminal inflammatory compression/SNL/PSNL/CCI/Bone cancer [28,45,47,57,66,70,71,76,79,86] Carbamazepine Trigeminal neuralgia [67] CAY10683 SNL [72] Trichostatin A PSNL/Bone cancer/CCI [76,[82][83][84][85] Valproic acid PSNL [76,84] JNJ26481585 (quinostat) Chemotrerapy-induced neuropathy [129] Bromodomain and extraterminal (BET) i-BET762 SNI [57] JQ1 Spinal cord injury [98] Histone deacetylase-bromodomain-containing proteins (HDAC/BRD) SUM52 SNI [58] SUM35 SNI [58] Silent information regulator (SIRT) Resveratrol (activator) Bortezomib-induced neuropathy [62] SRT1720 (activator) Bortezomib-induced neuropathy/CCI [62,64] Histone acetyltransferase (HAT) Anacardic acid PSNL [88,89] Histone methyltranserase G9a UNC0638 SNL [45,113] BIX01294 SNL [112] Enhancer of the histone methyltransferase zeste homolog-2 (EZH2) GSK503 SNL [45] Lysine demethylase 7A (KDM7A) NCDM-64 Chemotherapy-induced neuropathy [116] Author…”
Section: Discussionmentioning
confidence: 99%
“…In rats with CCI, SRT1720 exerted antihyperalgesic/antiallodynic actions and decreased CCI-induced overexpression of the molecular target of rapamycin (mTOR), NF-κB, interleukin (IL) 6, tumor necrosis factor α (TNF-α), and inducible nitric oxide synthase (iNOS) [63]. CCI-induced upregulation of the protein factor erythroblast transformation specific (ETS) proto-oncogene I (ETSI) in small-and medium-sized DRG neurons was responsible for mechanical allodynia and heat hyperalgesia in mice [64]. ETSI was shown to induce HDAC1 upregulation through binding to its promoter, ultimately leading to an increased expression of phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2) and glial fibrillary acidic protein (GFAP).…”
Section: Global Epigenetic Alterations Involving Histone Acetylation/...mentioning
confidence: 99%