Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism

Huang, Jiansheng; Tabbi-Anneni, Imène; Gunda, Viswanath; Wang, Li

doi:10.1152/ajpgi.00322.2010

Cited by 196 publications

(160 citation statements)

References 42 publications

Supporting

Mentioning

148

Contrasting

Order By: Relevance

“…These mice show reduced liver weight, hepatic fatty acid content as well as serum lipids [60] . Furthermore, in hepatocytes of the Nrf2-/-mice, the expression level of PPARγ gamma, fatty-acid synthase, stearoylCoA desaturase and regulatory-element binding protein that are involved in de novo lipogenesis were found to be reduced [60] . We suggest that the role of the Nrf2 system in lipid homeostasis is certain but complex.…”

Section: Role Of the Nrf2 System In Regulating Insulin Signaling And mentioning

confidence: 97%

Role of nuclear factor (erythroid-derived 2)-like 2 in metabolic homeostasis and insulin action: A novel opportunity for diabetes treatment?

Zhong

Li²,

Liu³

et al. 2012

WJD

View full text Add to dashboard Cite

Redox balance is fundamentally important for physiological homeostasis. Pathological factors that disturb this dedicated balance may result in oxidative stress, leading to the development or aggravation of a variety of diseases, including diabetes mellitus, cardiovascular diseases, metabolic syndrome as well as inflammation, aging and cancer. Thus, the capacity of endogenous free radical clearance can be of patho-physiological importance; in this regard, the major reactive oxygen species defense machinery, the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) system needs to be precisely modulated in response to pathological alterations. While oxidative stress is among the early events that lead to the development of insulin resistance, the activation of Nrf2 scavenging capacity leads to insulin sensitization. Furthermore, Nrf2 is evidently involved in regulating lipid metabolism. Here we summarize recent findings that link the Nrf2 system to metabolic homeostasis and insulin action and present our view that Nrf2 may serve as a novel drug target for diabetes and its complications.

show abstract

Section: Role Of the Nrf2 System In Regulating Insulin Signaling And mentioning

confidence: 97%

Role of nuclear factor (erythroid-derived 2)-like 2 in metabolic homeostasis and insulin action: A novel opportunity for diabetes treatment?

Zhong

Li²,

Liu³

et al. 2012

WJD

View full text Add to dashboard Cite

show abstract

“…GABP deficiency may protect against diet-induced weight gain, obesity, and glucose intolerance; GABP also impairs adipogenesis, as it decreases adipose tissue mass and adipocyte size (Zhang et al 2012) and modulates hepatic lipid homeostasis (Huang et al 2010). Therefore, GABP downregulation could have improved insulin sensitivity and directly decreased fatty acid content of hepatic triacylglycerols of the eWAT-transplanted Lep ob/ob mice.…”

Section: Novel Pathways Involved In Nafldmentioning

confidence: 99%

Molecular pathways involved in the improvement of non-alcoholic fatty liver disease

Paz-Filho

Mastronardi

Parker

et al. 2013

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis are components of the metabolic syndrome. Serum leptin levels are elevated in obesity, but the role of leptin in the pathophysiology of the liver involvement is still unclear. To identify the effects and mechanisms by which leptin influences the pathogenesis of NAFLD, we performed epididymal white adipose tissue (eWAT) transplantation from congenic wild-type mice into the subcutaneous dorsal area of Lep ob/ob recipient mice and compared the results with those of the Lep ob/ob sham-operated mice. The mice were followed for 102-216 days. During killing, the transplanted mice had significantly lost body weight and exhibited significantly higher leptin levels, improved glucose tolerance, and lower liver injury scores than the shamoperated mice. Liver microarray analysis showed that novel pathways related to GA-binding protein (GABP) transcription factor targets, pheromone binding, and olfactory signaling were differentially expressed in the transplanted mice. Our data also replicate pathways known to be involved in NAFLD, such as those involved in the regulation of microRNAs, lipid, glucose, and glutathione metabolism, peroxisome proliferator-activated receptor signaling, cellular regulation, carboxylic acid processes, iron, heme, and tetrapyrrole binding, immunity and inflammation, insulin signaling, cytochrome P450 function, and cancer. Conclusion: wild-type eWAT transplantation into Lep ob/ob mice led to improvements in metabolism, body weight, and liver injury, possibly attributed to the production of leptin by the transplanted eWAT. These improvements were accompanied by the differential expression of novel pathways. The causal relationship between GABP downregulation and NAFLD improvement remains to be determined.

show abstract

“…C/EBPβ promotes adipocyte differentiation, through the activation of C/EBPα and PPARγ. It has also been reported that exogenous PPARγ could affect the conversion of pre-adipocytes into mature fat cells (Huang et al, 2010;Yasmeen et al, 2012). Flavonoids are a type of plant polyphenols, with low molecular weight compositions.…”

Section: Introductionmentioning

confidence: 99%

Tangeritin inhibits adipogenesis by down-regulating C/EBPα, C/EBPβ, and PPARγ expression in 3T3-L1 fat cells

He¹,

Liu²,

Zhang³

2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The treatment of obese patients is a topic investigated by an increasing number of researchers. This study aimed to elucidate the possible inhibitory effect of tangeritin on the development and function of fat cells. 3T3-L1 fat cells were grown to confluence and subjected to different concentrations of tangeritin. The most effective tangeritin inhibition concentration was determined by the MTT assay. The treated cells were subjected to real-time reverse transcriptase PCR and western blot analysis, to detect changes in the CCAAT/enhancer binding protein (C/EBP)α, C/EBPβ, and peroxisome proliferator activated receptor (PPAR) γ expression levels. The MTT assay revealed that the fat cell growth was inhibited at a 20 ng/mL concentration of tangeritin. The results of realtime PCR revealed a significant decrease in the expression of C/EBPα, C/ EBPβ, and PPARγ mRNA, following the treatment with tangeritin. Western blot analysis also presented similar results at a protein level. Therefore, we concluded that tangeritin inhibits adipogenesis via the down-regulation of C/EBPα, C/EBPβ, and PPARγ mRNA and protein expression in 3T3-L1 cells.

show abstract

Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism

Cited by 196 publications

References 42 publications

Role of nuclear factor (erythroid-derived 2)-like 2 in metabolic homeostasis and insulin action: A novel opportunity for diabetes treatment?

Role of nuclear factor (erythroid-derived 2)-like 2 in metabolic homeostasis and insulin action: A novel opportunity for diabetes treatment?

Molecular pathways involved in the improvement of non-alcoholic fatty liver disease

Tangeritin inhibits adipogenesis by down-regulating C/EBPα, C/EBPβ, and PPARγ expression in 3T3-L1 fat cells

Contact Info

Product

Resources

About