Transcriptome analyses reveal common immune system dysregulation in PAH patients and Kcnk3‐deficient rats
Grégoire Ruffenach,
Hélène Le Ribeuz,
Mary Dutheil
et al.
Abstract:Pulmonary arterial hypertension (PAH) is a severe disease caused by progressive distal pulmonary artery obstruction. One cause of PAH are loss‐of‐function mutations in the potassium channel subfamily K member 3 (KCNK3). KCNK3 encodes a two‐pore domain potassium channel, which is crucial for pulmonary circulation homeostasis. However, our understanding of the pathophysiological mechanisms underlying KCNK3 dysfunction in PAH is still incomplete. Taking advantage of unique Kcnk3‐deficient rats, we analyzed the tr… Show more
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