Transcriptome analysis reveals deep insights into the early immune response of turbot (Scophthalmus maximus) induced by inactivated Aeromonas salmonicida vaccine

Xue, Ting; Liu, Yiping; Cao, Min; Li, Jie; Tian, Mengyu; Zhang, Lu; Wang, Beibei; Liu, Xiaoli; Li, Chao

doi:10.1016/j.fsi.2021.09.027

Cited by 11 publications

(4 citation statements)

References 51 publications

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“…However, a wide infection caused by A. salmonicida has been reported in different species of fish worldwide, including rainbow trout ( Oncorhynchus mykiss ), Atlantic salmon ( Salmo salar ), arctic char ( Salvelinus alpinus ), brook trout ( Salvelinus fontinalis ), brown trout ( Salmo trutta ), carp ( Cyprinus carpio ), goldfish ( Carassius auratus ), orange‐spotted grouper ( Epinephelus coioiaes ) and sablefish ( Anoplopoma fimbria ) from Canada, USA, Switzerland, Norway, France, South Korea, Spain, Chile, China and so on (Bartkova et al, 2010; Charette et al, 2012; Evenberg et al, 1986; Huang, Qi, Zuo, Alias, & Xu, 2020; Humphrey & Ashburner, 1993; Pylkkö et al, 2005; Valderrama et al, 2019; Vasquez et al, 2020). In particular, it is worth noting that, more and more studies in China on infection (Lian et al, 2020; Meng et al, 2020; Wang et al, 2020), pathogenicity (Chen et al, 2022; Meng et al, 2017; Yi et al, 2022) and interaction with hosts of A. salmonicida (Huang, Qi, Zuo, Alias, & Xu, 2020; Long et al, 2015; Xia et al, 2022; Xue et al, 2021) have been reported in recent years, implying the popularity and importance of this bacterium in China.…”

Section: Introductionmentioning

confidence: 99%

“…. In particular, it is worth noting that, more and more studies in China on infection (Lian et al, 2020;Meng et al, 2020;Wang et al, 2020), pathogenicity (Chen et al, 2022;Meng et al, 2017;Yi et al, 2022) and interaction with hosts of A. salmonicida (Huang, Qi, Zuo, Alias, & Xu, 2020;Long et al, 2015;Xia et al, 2022;Xue et al, 2021) have been reported in recent years, implying the popularity and importance of this bacterium in China.…”

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confidence: 99%

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Comparative genomic analysis provides insights into taxonomy and temperature adaption of Aeromonas salmonicida

Long

Fan

Gan

et al. 2023

Journal of Fish Diseases

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Aeromonas salmonicida is an important pathogen to both freshwater and marine fish in aquaculture (Dallaire-Dufresne et al., 2014).There are five subspecies reported so far: salmonicida, smithia, achromogenes, masoucida and pectinolytica (Cipriano & Bullock, 2001;Garrity et al., 2005). Initially, A. salmonicida is popular and often reported in areas with a relatively low average atmospheric temperature, for example, Canada (Morin, 2010), European countries (Bartkova et al., 2017), etc. However, a wide infection caused by A. salmonicida has been reported in different species of fish worldwide, including rainbow trout (Oncorhynchus mykiss), Atlantic salmon (Salmo salar), arctic char (Salvelinus alpinus), brook trout (Salvelinus fontinalis), brown trout (Salmo trutta), carp (Cyprinus carpio), goldfish (Carassius auratus), orange-spotted grouper (Epinephelus coioiaes) and sablefish (Anoplopoma fimbria) from

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Comparative genomic analysis provides insights into taxonomy and temperature adaption of Aeromonas salmonicida

Long

Fan

Gan

et al. 2023

Journal of Fish Diseases

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“…The spatial separation between each infected site on the skin and the variance in immune expression between uninfected and infected skin in T. ovatus trevally following C. irritans infection remains unclear. In recent times, a growing body of evidence indicates that non-coding RNAs (ncRNAs), such as miRNAs and lncRNAs, play crucial regulatory roles in gene expression networks, thereby influencing various biological processes, particularly immune regulation [22][23][24][25][26][27]. In order to gain a deeper understanding of the differences in innate immunity between uninfected and infected skin, we conducted a systematic comparison of the entire transcriptome of infected, adjacent, and infected versus adjacent skin (ATT_vs_PER, ADJ_vs_PER, ATT_vs_ADJ).…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis Reveals Functional Interaction of mRNA-lncRNA-miRNA in Trachinotus ovatus Infected by Cryptocaryon irritans

Liu,

San,

Guo

et al. 2023

IJMS

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The skin of Trachinotus ovatus is a crucial component of the mucosal immune system and serves as the primary site of infection by Cryptocaryon irritans. In order to investigate the significant role of skin in C. irritans infection, a comprehensive transcriptome analysis was conducted on skin tissues from the infection group, infection-adjacent group, and infection group compared with the infection-adjacent group (ATT_vs_PER, ADJ_vs_PER, ATT_vs_ADJ). This study identified differentially expressed long non-coding RNAs (DE lncRNAs), microRNAs (DE miRNAs), and differentially expressed genes (DEGs). The prediction of lncRNA target genes was accomplished by utilizing positional relationship (co-location) and expression correlation (co-expression) with protein-coding genes. Subsequently, functional enrichment analysis was conducted on the target genes of differentially expressed lncRNAs, revealing their involvement in signaling pathways such as tight junction, MAPK, and cell adhesion molecules. This study describes the regulatory network of lncRNA-miRNA-mRNA in T. ovatus skin tissue infected with C. irritans. Functional prediction analysis showed that differentially expressed lncRNA and miRNA may regulate the expression of immune genes such as interleukin-8 (il8) to resist the infection of C. irritans. Conducting additional research on these non-coding RNAs will facilitate a deeper understanding of their immune regulatory function in T. ovatus during C. irritans infection. The study of non-coding RNA in this study laid a foundation for revealing the molecular mechanism of the immune system of T. ovatus to respond to the infection of C. irritans. It provided a choice for the molecular breeding of Trachinotus ovatus against C. irritans.

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“…The peak antigen uptake in skin and muscle was significantly higher in the intramuscular injection ( 309 ). Moreover, the expression of antigen presentation-related genes (CD4-1, MHC IIα, CD8α, MHC Iα) in the spleen, head kidney, liver and hindgut of flounder, and the proportion of sIgM + cells in the spleen and peripheral blood were higher in the intraperitoneal injection group than in the intramuscular immunization group ( 310 , 311 ). Both cellular immunity (including cytotoxicity) and humoral immunity are activated by nucleic acid vaccination.…”

Section: Mechanism Of Aquatic Vaccinesmentioning

confidence: 98%

Current status and development prospects of aquatic vaccines

Liu

et al. 2022

Front. Immunol.

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Diseases are a significant impediment to aquaculture’s sustainable and healthy growth. The aquaculture industry is suffering significant financial losses as a result of the worsening water quality and increasing frequency of aquatic disease outbreaks caused by the expansion of aquaculture. Drug control, immunoprophylaxis, ecologically integrated control, etc. are the principal control strategies for fish infections. For a long time, the prevention and control of aquatic diseases have mainly relied on the use of various antibiotics and chemical drugs. However, long-term use of chemical inputs not only increases pathogenic bacteria resistance but also damages the fish and aquaculture environments, resulting in drug residues in aquatic products, severely impeding the development of the aquaculture industry. The development and use of aquatic vaccines are the safest and most effective ways to prevent aquatic animal diseases and preserve the health and sustainability of aquaculture. To give references for the development and implementation of aquatic vaccines, this study reviews the development history, types, inoculation techniques, mechanisms of action, development prospects, and challenges encountered with aquatic vaccines.

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Transcriptome analysis reveals deep insights into the early immune response of turbot (Scophthalmus maximus) induced by inactivated Aeromonas salmonicida vaccine

Cited by 11 publications

References 51 publications

Comparative genomic analysis provides insights into taxonomy and temperature adaption of Aeromonas salmonicida

Comparative genomic analysis provides insights into taxonomy and temperature adaption of Aeromonas salmonicida

Transcriptomic Analysis Reveals Functional Interaction of mRNA-lncRNA-miRNA in Trachinotus ovatus Infected by Cryptocaryon irritans

Current status and development prospects of aquatic vaccines

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