Transcriptome analysis to reveal the mechanism of the effect of Echinops latifolius polysaccharide B on palmitate-induced insulin-resistant

Li, Ran; Xia, Yajuan; Gao, Zhenzhen; Song, Yue

doi:10.1016/j.biopha.2021.112203

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…Differentially expressed genes (DEGs) (or lncRNA (DELs) and miRNAs (DEMs)) were identified between different liver tissues using R package ‘limma.’ For DEGs, the threshold of absolute fold-change was more than 2. For DELs and DEMs, the threshold of absolute fold-change was more than 1.5 ( Li et al, 2021 ; Weiner et al, 2021 ). For DEGs/DELs/DEMs, the adjusted p-value was less than 0.05.…”

Section: Methodsmentioning

confidence: 99%

The LINC00261/MiR105-5p/SELL axis is involved in dysfunction of B cell and is associated with overall survival in hepatocellular carcinoma

Song

Huang

et al. 2022

PeerJ

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Background Previous studies have been reported the immune dysfunction of various live tissues. However, the potential molecular mechanism of post-transcriptional regulation of immune related genes in hepatocellular carcinoma (HCC) is still not clear. We tried to identify crucial immune related biomarkers associated with HCC patients’ outcomes and to reveal the transcriptional regulation. Method The fractions of 22 immune cells in tumor and adjacent tissues were estimated by CIBERSORT. Kruskal-Wallis test and differentially expressed analyzes were used for comparative studies. Cox proportional hazard regression model, Kaplan-Meier estimates and Log-rank test were used for survival analyses. Results From The Cancer Genome Atlas (TCGA), the gene, lncRNA and miRNA expression profiles of 379 HCC samples with clinical information were used for comparative studies. Eleven adaptive and innate immune cell types were significantly altered in HCC samples, including B cell memory, regulatory T cells and follicular helper T cells. Differentially expressed competing endogenous RNA (ceRNA) network associated with patients’ overall survival was identified. Then, the novel pathway, including LINC00261, MiR105-5p and selectin L(SELL) was found and may be potential novel biomarkers for patients’ outcomes and immunotherapy. Furthermore, SELL was significantly positively correlated (correlation coefficients: 0.47–0.69) with 12 known gene signatures of immunotherapy except for programmed cell death 1 (PDCD1). Conclusions Our findings could provide insights into the selection of novel LINC00261/MiR105-5p/SELL pathway which is associated with overall survival and may impact on efficacy of immunotherapy in HCC.

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Section: Methodsmentioning

confidence: 99%

The LINC00261/MiR105-5p/SELL axis is involved in dysfunction of B cell and is associated with overall survival in hepatocellular carcinoma

Song

Huang

et al. 2022

PeerJ

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“…Diabetes can cause various acute and chronic complications, such as diabetes ketoacidosis, lactic acidosis, hypoglycemia, hyperosmolar hyperglycemia, nerve injury and vascular disease, and even cause organ failure or death in severe cases. [108,109] Insulin secretion of islet lymphocytes reduced, and the secretion of hyperglycemic hormones (such as glucagon, growth hormone, cortisol, etc.) increased, which is mainly due to islet 𝛽 cell damage, GM disorder, liver metabolism disorder, autoimmune system disorder, obesity, endocrine system disorder during pregnancy and virus infection, and ultimately led to the occurrence of diabetes.…”

Section: Hypoglycemic Activitymentioning

confidence: 99%

Research Progress on Biological Activities of Polysaccharides from Edible Fungus

et al. 2023

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Edible fungus is widely eaten because of their delicious taste and high nutritional value. Growing evidence indicates that edible fungus is rich in various active ingredients including polysaccharides, proteins, fats, vitamins, and other ingredients. Polysaccharides are one of the main active ingredients of edible fungi. Increasing research has confirmed that edible fungus polysaccharides (EFPs) show multiple biological activities such as antioxidant, anti-inflammatory, anti-tumor, immune regulation, anti-virus, gut microbiota regulation, hypoglycemic, etc. Hence, EFP related research has received more and more attention due to their non-toxic, high medical, and nutritional values. This paper reviews the latest research progress of EFPs biological activities, and looks forward to their future development trend. This review provides a theoretical basis for studying the application of EFPs in the fields of biomedicine, cosmetics, health food, and promotes the development and utilization of EFPs.

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Molecular mechanism of microRNA-mediated hypoglycemic effect of whole grain highland barley

Qin,

Ren,

Zhang

et al. 2024

Gene

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Transcriptome analysis to reveal the mechanism of the effect of Echinops latifolius polysaccharide B on palmitate-induced insulin-resistant

Cited by 5 publications

References 43 publications

The LINC00261/MiR105-5p/SELL axis is involved in dysfunction of B cell and is associated with overall survival in hepatocellular carcinoma

The LINC00261/MiR105-5p/SELL axis is involved in dysfunction of B cell and is associated with overall survival in hepatocellular carcinoma

Research Progress on Biological Activities of Polysaccharides from Edible Fungus

Molecular mechanism of microRNA-mediated hypoglycemic effect of whole grain highland barley

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