2014
DOI: 10.4149/neo_2014_025
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Transcriptome profiling of malignant transformed rat hepatic stem-like cells by aflatoxin B1

Abstract: Exposure to aflatoxins is strongly associated with hepatocellular carcinoma (HCC). Hepatic progenitor cells have been suggested to participate in the development of HCC. To further explore the molecular basis of aflatoxin-induced carcinogenesis, we utilized transcriptome profiles to examine the global gene expression alterations of malignant transformed rat hepatic stem-like cells. WB-F344 cells were treated with continuous exposure to AFB1 (0.03, 0.1 and 0.2μM), and gained certain characteristics of transform… Show more

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Cited by 9 publications
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