Transcriptome Reveals That Genic SNPs Contributes to Heterosis in Cattle

Wu, Jianghong; Gong, Husile; Luan, Qing-Jiang; Xue, Ling; Sun, Huichao; Wang, Feng

doi:10.2991/bst-17.2018.17

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Among the world-wide commercial beef cattle, Red Angus is one of the most popular beef cattle breeds that has been widely used in crossbreeding programs to improve the carcass quality traits of local breeds. This breed has been separately registered from the black Angus cattle and is well known for its excellent carcass traits including marbling (intra-muscular fat) [14,15]. As early as in 2000, by crossing this commercial breed with local populations that originated from Mongolian cattle (such as Chinese Steppes Red), a new cross-bred composite was generated with a variety of excellent characteristics, such as good meat quality, rapid growth and high adaptation ability to withstand extreme local climate conditions.…”

Section: Introductionmentioning

confidence: 99%

Genomic adaptation to extreme climate conditions in beef cattle as a consequence of cross-breeding program

et al. 2023

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Background Understanding the evolutionary forces related to climate changes that have been shaped genetic variation within species has long been a fundamental pursuit in biology. In this study, we generated whole-genome sequence (WGS) data from 65 cross-bred and 45 Mongolian cattle. Together with 62 whole-genome sequences from world-wide cattle populations, we estimated the genetic diversity and population genetic structure of cattle populations. In addition, we performed comparative population genomics analyses to explore the genetic basis underlying variation in the adaptation to cold climate and immune response in cross-bred cattle located in the cold region of China. To elucidate genomic signatures that underlie adaptation to cold climate, we performed three statistical measurements, fixation index (FST), log2 nucleotide diversity (θπ ratio) and cross population composite likelihood ratio (XP-CLR), and further investigated the results to identify genomic regions under selection for cold adaptation and immune response-related traits. Results By generating WGS data, we investigated the population genetic structure and phylogenetic relationship of studied cattle populations. The results revealed clustering of cattle groups in agreement with their geographic distribution. We detected noticeable genetic diversity between indigenous cattle ecotypes and commercial populations. Analysis of population structure demonstrated evidence of shared genetic ancestry between studied cross-bred population and both Red-Angus and Mongolian breeds. Among all studied cattle populations, the highest and lowest levels of linkage disequilibrium (LD) per Kb were detected in Holstein and Rashoki populations (ranged from ~ 0.54 to 0.73, respectively). Our search for potential genomic regions under selection in cross-bred cattle revealed several candidate genes related with immune response and cold shock protein on multiple chromosomes. We identified some adaptive introgression genes with greater than expected contributions from Mongolian ancestry into Molgolian x Red Angus composites such as TRPM8, NMUR1, PRKAA2, SMTNL2 and OXR1 that are involved in energy metabolism and metabolic homeostasis. In addition, we detected some candidate genes probably associated with immune response-related traits. Conclusion The study identified candidate genes involved in responses to cold adaptation and immune response in cross-bred cattle, including new genes or gene pathways putatively involved in these adaptations. The identification of these genes may clarify the molecular basis underlying adaptation to extreme environmental climate and as such they might be used in cattle breeding programs to select more efficient breeds for cold climate regions.

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Section: Introductionmentioning

confidence: 99%

Genomic adaptation to extreme climate conditions in beef cattle as a consequence of cross-breeding program

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Among the world-wide commercial beef cattle, the Red Angus is one of the most popular beef cattle breed that has been widely used in crossbreeding programs to improve the carcass quality traits of local breeds. This breed has been separately registered from the black Angus cattle and is well known for its excellent carcass traits, due to its intra muscular marbling [13,14]. As early as in 1970, by crossing this commercial breed with those local populations that originated from Mongolian cattle (such as Chinese Steppes Red), a new cross-bred cattle was generated with a variety of excellent characteristics, such as good meat quality, rapid growth and high adaptation ability to extreme local climate conditions.…”

mentioning

confidence: 99%

Genomic adaptation to extreme climate conditions in beef cattle as a consequence of cross-breeding program

Tian

Nanaie

Wang

et al. 2022

Preprint

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BackgroundUnderstanding the evolutionary forces related to climate changes that have been shaped genetic variation within species has long been a fundamental pursuit in biology. In this study, we generated whole-genome sequence (WGS) data from 65 cross-bred and 45 Mongolian cattle breeds. Together with 61 whole-genome sequences from world-wide cattle populations, we estimated the genetic diversity and population genetic structure of cattle populations. In addition, we performed comparative population genomics analyses to explore the genetic basis underlying variation in the adaptation to cold climate and immune response in cross-bred cattle located in the cold region of China. To elucidate genomic signatures that underlie adaptation to cold climate, we performed statistical measurements, FST and nucleotide diversity (θπ), and further investigated the results to identify genomic regions under selection for cold adaptation and immune response-related traits.ResultsBy generating whole-genome sequencing data, we first investigated the population genetic structure and phylogenetic relationship of studied cattle populations. The results revealed clustering of cattle groups in agreement with their geographic distribution. We detected noticeable genetic diversity between indigenous cattle ecotypes and commercial populations. Analysis of population structure demonstrated evidence of shared genetic ancestry between studied cross-bred population and both Red-Angus and Mongolian breeds. Among the all studied cattle populations, the highest and lowest levels of linkage disequilibrium (LD) were detected in Holstein and Rashoki populations (ranged from ~ 0.54 to 0.73, respectively) at marker pairs distance of 1 Kb. Our search for potential genomic regions under selection in cross-bred cattle revealed several candidate genes related with immune response and cold shock protein-related traits. In particular, we identified some adaptive introgression genes such as TRPM8, NMUR1, PRKAA2, SMTNL2 and OXR1 that are involved in energy metabolism and metabolic homeostasis. In addition, we detected some candidate genes on different chromosomes probably associated with immune response-related traits. ConclusionsThe study identified candidate genes involved in responses to cold adaptation and immune response in cross-bred cattle, including new genes or gene pathways putatively involved in these adaptations. The identification of these genes may be helpful in understanding of the molecular basis of adaptation to extreme environmental climate and as such they should be used in cattle breeding programs to select more efficient breeds for cold climate regions.

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Transcriptome Reveals That Genic SNPs Contributes to Heterosis in Cattle

Cited by 2 publications

References 23 publications

Genomic adaptation to extreme climate conditions in beef cattle as a consequence of cross-breeding program

Genomic adaptation to extreme climate conditions in beef cattle as a consequence of cross-breeding program

Genomic adaptation to extreme climate conditions in beef cattle as a consequence of cross-breeding program

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