Transcriptome sequencing analysis reveals miR-30c-5p promotes ferroptosis in cervical cancer and inhibits growth and metastasis of cervical cancer xenografts by targeting the METTL3/KRAS axis

Gong, Yangmei; Luo, Guifang; Zhang, Shufen; Chen, Yijing; Hu, Yi

doi:10.1016/j.cellsig.2024.111068

Cited by 7 publications

(1 citation statement)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, miR-30c-5p promotes the ferroptosis of cervical cancer by targeting the METTL3/KRAS axis, and inhibits the growth and metastasis of xenografts of cervical cancer. Targeting this process can be effectively treated ( Gong et al, 2024 ).…”

Section: A Modification Regulates the Occurrence Of Ferroptosismentioning

confidence: 99%

Correlation between RNA N6-methyladenosine and ferroptosis in cancer: current status and prospects

Liu,

Lv,

Cai

et al. 2024

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

N6-methyladenosine (m6A) is the most abundant chemical modification in eukaryotic cells. It is a post-transcriptional modification of mRNA, a dynamic reversible process catalyzed by methyltransferase, demethylase, and binding proteins. Ferroptosis, a unique iron-dependent cell death, is regulated by various cell metabolic events, including many disease-related signaling pathways. And different ferroptosis inducers or inhibitors have been identified that can induce or inhibit the onset of ferroptosis through various targets and mechanisms. They have potential clinical value in the treatment of diverse diseases. Until now, it has been shown that in several cancer diseases m6A can be involved in the regulation of ferroptosis, which can impact subsequent treatment. This paper focuses on the concept, function, and biological role of m6A methylation modification and the interaction between m6A and ferroptosis, to provide new therapeutic strategies for treating malignant diseases and protecting the organism by targeting m6A to regulate ferroptosis.

show abstract

Section: A Modification Regulates the Occurrence Of Ferroptosismentioning

confidence: 99%

Correlation between RNA N6-methyladenosine and ferroptosis in cancer: current status and prospects

Liu,

Lv,

Cai

et al. 2024

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

N⁶‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

Cui,

Li,

Huang

et al. 2024

Immunity Inflam & Disease

View full text Add to dashboard Cite

BackgroundN6‐methyladenosine (m6A) modification is a widespread and reversible epigenetic alteration in eukaryotic mRNA, playing a pivotal role in various biological functions. Its significance in female reproductive development and associated diseases has recently become a focal point of research.ObjectiveThis review aims to consolidate current knowledge of the role of m6A modification in female reproductive tissues, emphasizing its regulatory dynamics, functional significance, and implications in reproductive health and disease.MethodsA comprehensive analysis of recent studies focusing on m6A modification in ovarian development, oocyte maturation, embryo development, and the pathogenesis of reproductive diseases.Resultsm6A modification exhibits dynamic regulation in female reproductive tissues, influencing key developmental stages and processes. It plays critical roles in ovarian development, oocyte maturation, and embryo development, underpinning essential aspects of reproductive health. m6A modification is intricately involved in the pathogenesis of several reproductive diseases, including polycystic ovary syndrome (PCOS), premature ovarian failure (POF), and endometriosis, offering insights into potential molecular mechanisms and therapeutic targets.ConclusionThe review highlights the crucial role of m6A modification in female reproductive development and related diseases. It underscores the need for further research to explore innovative diagnostic and therapeutic strategies for reproductive disorders, leveraging the insights gained from understanding m6A modification's impact on reproductive health.

show abstract

Epitranscriptomics and cervical cancer: the emerging role of m⁶A, m⁵C and m¹A RNA modifications

Modi,

Zahid,

Southerland

et al. 2024

Expert Rev. Mol. Med.

View full text Add to dashboard Cite

Cervical cancer (CC), one of the most prevalent and detrimental gynaecologic cancers, evolves through genetic and epigenetic alterations resulting in the promotion of oncogenic activity and dysfunction of tumour-suppressing mechanisms. Despite medical advancement, the prognosis for advanced-stage patients remains extremely low due to high recurrence rates and resistance to existing treatments. Thereby, the search for potential prognostic biomarkers is heightened to unravel new modalities of CC pathogenesis and to develop novel anti-cancer therapies. Epitranscriptomic modifications, reversible epigenetic RNA modifications, regulate various biological processes by deciding RNA fate to mediating RNA interactions. This narrative review provides insight into the cellular and molecular roles of endogenous RNA-editing proteins and their associated epitranscriptomic modifications, especially N6-methyladenosine (m6A), 5-methylcytosine (m5C) and N1-methyladenosine (m1A), in governing the development, progression and metastasis of CC. We discussed the in-depth epitranscriptomic mechanisms underlying the regulation of over 50 RNAs responsible for tumorigenesis, proliferation, migration, invasion, survival, autophagy, stemness, epithelial-mesenchymal transition, metabolism (glucose, lipid, glutamate and glutamine), resistance (drug and radiation), angiogenesis and recurrence of CC. Additionally, we provided a concise overview of the therapeutic potential of targeting the altered expression of endogenous RNA-editing proteins and aberrant deposition of RNA modifications on both coding and non-coding RNAs in CC.

show abstract

Transcriptome sequencing analysis reveals miR-30c-5p promotes ferroptosis in cervical cancer and inhibits growth and metastasis of cervical cancer xenografts by targeting the METTL3/KRAS axis

Cited by 7 publications

References 45 publications

Correlation between RNA N6-methyladenosine and ferroptosis in cancer: current status and prospects

Correlation between RNA N6-methyladenosine and ferroptosis in cancer: current status and prospects

N⁶‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

Epitranscriptomics and cervical cancer: the emerging role of m⁶A, m⁵C and m¹A RNA modifications

Contact Info

Product

Resources

About

Transcriptome sequencing analysis reveals miR-30c-5p promotes ferroptosis in cervical cancer and inhibits growth and metastasis of cervical cancer xenografts by targeting the METTL3/KRAS axis

Cited by 7 publications

References 45 publications

Correlation between RNA N6-methyladenosine and ferroptosis in cancer: current status and prospects

Correlation between RNA N6-methyladenosine and ferroptosis in cancer: current status and prospects

N6‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

Epitranscriptomics and cervical cancer: the emerging role of m6A, m5C and m1A RNA modifications

Contact Info

Product

Resources

About

N⁶‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

Epitranscriptomics and cervical cancer: the emerging role of m⁶A, m⁵C and m¹A RNA modifications