2024
DOI: 10.1038/s41598-024-58904-z
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Transcriptomic alterations in cortical astrocytes following the development of post-traumatic epilepsy

John Leonard,
Xiaoran Wei,
Jack Browning
et al.

Abstract: Post-traumatic epilepsy (PTE) stands as one of the numerous debilitating consequences that follow traumatic brain injury (TBI). Despite its impact on many individuals, the current landscape offers only a limited array of reliable treatment options, and our understanding of the underlying mechanisms and susceptibility factors remains incomplete. Among the potential contributors to epileptogenesis, astrocytes, a type of glial cell, have garnered substantial attention as they are believed to promote hyperexcitabi… Show more

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